42 results about "DrugBank" patented technology

A pharmacy robot device comprises a chassis, a pharmacy, push rod equipment, a conveyor belt and an induction door, and is used for executing the functions of drug replenishment, delivery and inventory, and an AI verification system and an intelligent diagnosis system are combined to realize physician service, pharmacist service and pharmaceutical affair service of the pharmacy. According to requirements, a plurality of pharmacy robot devices can be linked in parallel or in series, the variety and number of stored drugs are increased, the device is simple in structure and flexible to deploy and configure, and therefore, the operation cost of a pharmacy shop is reduced.

An implantable shock electrode line having a proximal terminal for connection to an implantable defibrillator, an elongated flexible line body, and a shock electrode and a drug delivery device arranged at or near the distal end of the line body. A drug depot connected to the drug delivery device is provided in the shock electrode line, and the terminal is designed as a purely electric standard terminal. The drug delivery device is designed for control by an electric pulse transmitted over the electric terminal to the shock electrode line.

The invention relates to a method for screening hypoglycemic active components of cornus officinalis. The method comprises the following steps of: establishing a cornus officinalis aqueous extract component analysis method by using a chromatography-mass spectrometry technology, and identifying active components in cornus officinalis through data analysis; carrying out similarity comparison on chemical structures of the active components and a DrugBank database, and setting a similarity scoring card value to be 0.8 so as to obtain a component target; retrieving a disease / syndrome target database to obtain candidate disease targets of diabetes; carrying out related hypoglycemic effect target prediction on the chemical components of the cornus officinalis by adoption of a network pharmacologic technology, constructing a cornus officinalis component-hypoglycemic target-role access network, and predicting potential hypoglycemic active components and a molecular mechanism; and carrying out activity evaluation and experimental verification on the potential active components through cell experiment so as to determine real and effective hypoglycemic active components in the cornus officinalis. The method is capable of improving the cornus officinalis active component screening efficiency and reducing the drug active component screening cost.

The invention relates to a transdermal drug delivery system having a structure with two layers namely a drug storage layer and a sticking layer. The drug is stored in the drug storage layer in an over-saturated state. The matrix materials of the drug storage layer and the sticking layer are chosen from polyacrylate, polysiloxane and polyisobutylene, and are not the same material at the same time. The transdermal drug delivery system can realize the constant drug releasing.

The invention discloses a regional collaborative linkage medication management method and system based on an NFC visual smart card. The system disclosed by the invention comprises a collaborative medical platform, a smart drug library system, a hospital management information system, a family doctor subsystem and a patient subsystem, which can separately perform information interaction with the visual smart card. The method comprises the following steps: writing prescription information into the visual smart card at the hospital management information system or through the collaborative medical platform, and using the visual smart card to trigger an electronic label at a position of a smart drug library corresponding to the medicine in the prescription information at the smart drug librarysystem to send medicine withdrawal prompt, and after the medicine withdrawal is completed, performing, the visual smart card and the electronic label, delivery information, and uploading a patient medicine withdrawal record to the collaborative medical platform. During the medication treatment of a patient, the medication effect information is uploaded to the collaborative medical platform through the smart card, the family doctor subsystem and the patient subsystem.

The invention discloses an automatic traditional Chinese medicine prescription dispensing system. The automatic traditional Chinese medicine prescription dispensing system comprises a plurality of three-dimensional medicine storages and a dispensing table, wherein a medicine box moving mechanism is arranged between the three-dimensional medicine storages and the dispensing table, a medicine box switching device is arranged between the dispensing table and the medicine box moving mechanism, each three-dimensional medicine storage is composed of a storage rack and a plurality of medicine boxes,identification marks capable of storing and reading information are arranged on the medicine boxes, the three-dimensional medicine storages are provided with stacking mechanisms, and the dispensing table comprises a rack, a control table arranged on the rack, a plurality of taking windows, a general weighing platform for weighing medicines, a main display for receiving prescriptions and displayingrelated information, and a medicine box information display for reading and then displaying medicine box information in the current taking window. Automatic operation is adopted in the whole feedingprocess, so that personnel requirements are less, and personnel quality requirements are lower; the working environment is improved, and the mobility of personnel is reduced; the operation difficultyis low, the mastering speed is high, the manual error and the loss of medicinal materials are reduced, and the traceability of prescription dispensing is improved.

The invention relates to an FM-N-DNN-based drug and target interaction prediction method. The method comprises the following steps of: S1, obtaining drug and target interaction pairs from a DrugBank database and marking the drug and target interaction pairs as a positive samples; S2, dividing the drug and target interaction pairs into different drugs and targets and then forming an independent drug group and an independent target group; randomly selecting drugs and targets from the drug group and the target group to construct new drug and target interaction pairs, and marking samples which arenot positive samples in the newly constructed drug and target interaction pairs as negative samples; S3, extracting feature vectors of the positive samples and the negative samples by utilizing an open source python software package PyDPI; S4, preprocessing the feature vectors extracted in the step S3; S5, constructing an FM-N-DNN model and training the FM-N-FNN model by utilizing the feature vectors of the positive samples and the negative samples; and S6, predicting a drug and target interaction by utilizing the trained FM-N-DNN model.

The invention provides a medicine discharging method and device of a medicine storehouse, the medicine storehouse and a storage medium. The medicine discharging method comprises the steps: obtaining aplurality of prescriptions which comprise a plurality of medicine types and the number of dispensed medicines corresponding to each medicine type; obtaining a plurality of to-be-supplemented medicinetypes from the plurality of prescriptions, the total storage amount of each to-be-supplemented medicine type in the medicine dispensing equipment being smaller than the sum of the medicine dispensingamounts of the to-be-supplemented medicine type in the plurality of first prescriptions; performing the following operations on each to-be-supplemented medicine type: obtaining medicines corresponding to the to-be-supplemented medicine types from a second-level library and storing the medicines into the medicine dispensing equipment, so that the sum of the medicine dispensing quantities of the to-be-supplemented medicine types in the plurality of prescriptions is less than or equal to the total storage quantity of the to-be-supplemented medicine types in the medicine dispensing equipment; andcontrolling the medicine dispensing equipment to complete the medicine dispensing operation of the plurality of prescriptions. It can be understood that according to the medicine discharging method,the medicines are not discharged according to the sequence of the prescriptions one by one, but multiple prescriptions are discharged at the same time, and therefore, the work efficiency of the medicine storehouse can be improved.

The invention relates to a molecular virtual screening method based on protein sequence alignment, which comprises the following steps: according to an input protein sequence to be subjected to molecular screening, acquiring multi-sequence coupling information of protein by using an HHbits program; the frequency PSFM of the same residues appearing at the corresponding positions of the protein sequence to be predicted and the multi-sequence coupling information being calculated; by using the same method, generating the PSFM of each protein sequence in a protein-ligand interaction database BioLiP; calculating the residue alignment score and similarity matching quality of the to-be-predicted protein and each protein in BioLiP, and obtaining a potential seed molecule set according to the matching quality score; and calculating the sum of the two-dimensional fingerprint values of each molecule in the molecule database and all the molecules in the seed molecule set, sorting all the molecules in the DrugBank according to scores, and obtaining x.NDrugBank molecules with the top scores as a molecular sieve selection set of protein sequences to be subjected to molecular screening. The method can be used for any screening scene.

A medical service resource optimization system based on multi-pharmacy collaboration technology, including a virtual drug library as a data center, which collects, stores, analyzes and uses data in a standardized manner; the computing center can schedule intelligent optimization algorithms to calculate the inventory of multiple pharmacies in real time , out-of-stock, etc., according to the patient's historical drug purchase records, etc., portray patient portraits, obtain group labels, and predict market demand; the situation awareness module obtains the patient's situation through sensors, etc., and the computing center gives "one person, one policy" personalized Service plan; the display interface provides each member with the optimal decision-making plan, such as the best place for patients to take medicine; the feedback center supports multiple ways of taking medicine, such as online ordering store pickup, online ordering store delivery, etc., and sends them to the corresponding pharmacy in real time through the panel. The invention helps to realize the service-oriented, profitable and refined pharmaceutical supply chain, optimize the allocation of medical service resources, support new medical service modes such as telemedicine, mobile medical treatment, and smart medical treatment, and improve the level of medical service in my country.

The invention discloses a method and device for sorting medicines in a medicine storehouse, a medicine storehouse and a storage medium. The method for sorting medicines includes: detecting that medicines are put into the medicine inlet; For N prescriptions corresponding to several drug distribution ports, M prescriptions lacking the drug are obtained from the N prescriptions, and the target prescription is selected from the M prescriptions, where N and M are natural numbers, and M≤ N, the prescription is used to record the number of medicines that are still missing in the one-to-one corresponding medicine basket and the missing quantity corresponding to each medicine, and the prescription is in one-to-one correspondence with the dispensing port. Among the M prescriptions , the distance between the drug dispensing port corresponding to the target prescription and the basket outlet is the shortest; the sorter is controlled to sort the medicines from the drug dispensing port corresponding to the target prescription. Thus, the efficiency of sorting medicines can be greatly improved.

The invention provides an injection dispensing system, and relates to the field of automatic equipment. The injection dispensing system comprises a dispensing information acquisition module, a dispensing information processing module, a medicine storehouse, a medicine grabbing module and a medicine transportation module, wherein the dispensing information acquisition module is used for acquiring dispensing order information and sending the dispensing order information to the dispensing information processing module; the medicine storehouse comprises a plurality of medicine storage cabinets; the dispensing information processing module stores position information of various medicines in the medicine warehouse; the dispensing information processing module is further used for receiving the dispensing order information acquired by the dispensing information acquisition module, generating type information of to-be-grabbed medicines, position information of each kind of to-be-grabbed medicines and quantity information of each kind of to-be-grabbed medicines according to the dispensing order information and sending the type information of to-be-grabbed medicines, the position informationand the quantity information of each kind of to-be-grabbed medicines to the medicine grabbing module; the medicine grabbing module is used for grabbing medicines and transporting the medicines to themedicine transportation module; and the medicine transportation module is used for transporting the medicines out of the medicine warehouse. The system has the advantages that the labor force requiredfor dispensing is reduced, and the dispensing work efficiency is improved.

The invention belongs to the field of drug target screening, and in particular relates to a screening method for c-di-AMP synthetase inhibitor of Streptococcus suis and application thereof. Based on the chemiluminescence method, the DacA enzyme activity is reflected according to the relative luminescence value in the reaction system. The reaction system is composed of Streptococcus suis SC19 c‑di‑AMP synthetase functional domain DacA (99‑283), ATP, enzyme activity reaction buffer and Reagent. According to the high-throughput screening judgment standard, the Z value of the chemiluminescent method, the ratio of the signal to the background and the average value of the coefficient of variation of the signal values ​​of the negative and positive test groups are calculated, and the present invention meets the high-throughput screening standard. The screening of the drug library of the present invention identifies a compound, namely the inhibitor IPA-3, which has inhibitory effect on c-di-AMP synthetase of Streptococcus suis and Gram-positive bacteria of Streptococcus suis.

The invention discloses an intelligent pharmacy service system and a realization method thereof. The intelligent pharmacy service system includes a user terminal, a user terminal server, a checkout system server and an intelligent drug storehouse system which are in communication connection in sequence, and a printing system which is in communication connection with the user terminal server and the checkout system server. An intelligent access device and an intelligent drug shelf are used to store drugs. By using the intelligent access device, the space is fully utilized, the storage capacityof drugs is increased, and the floor area is greatly reduced. The open intelligent drug shelf for storing drugs meets the selection and purchase demand of the elderly. By combining the intelligent access device and the intelligent drug shelf, real-time interaction of drug inventory information and sales data is realized, and the dependence on human is reduced while the efficiency is increased. Anintelligent drug storehouse server configures the drug pickup position according to an optimal path, sends drugs to the drug pickup window of the intelligent access device and automatically indicatesthe drug storage position, which significantly improves the efficiency of drug pickup.

The invention belongs to the field of computer science and discloses a method for discovering anti-coronavirus inflammatory drugs based on network representation. First, build a multi-source, heterogeneous, large-scale biomedical network by integrating multiple databases such as DrugBank, UniProt, HPRD, SIDER, CTD, NDFRT, and STRING; then, perform sequence sampling in the network to form a network by random walk The sequence library is characterized by using Transformer's deep bidirectional encoder characterization technology to obtain the representation vector of each node; the inductive matrix decomposition technology is used to predict target-drug interactions, discover potential anti-COVID-19 inflammatory drugs, and infer related The mechanism of action of the drug. The present invention provides a multi-layer correlation knowledge for drug research and development by integrating multi-source heterogeneous information and diversified data, thereby improving the prediction accuracy; secondly, the Transformer model integrates the multi-head attention mechanism, which can capture the network in different degrees The correlation between nodes and the physical distance of network nodes can improve the performance of representation.