31 results about "DrugBank" patented technology

The invention discloses a drug interaction prediction method based on multi-dimensional features, and relates to the technical field of drug interaction prediction, and the method comprises the following steps: S1, collecting multi-dimensional feature information of drugs from authoritative databases DrubBank, KEGG and Pubchemm, and obtaining drug features; meanwhile, real clinical case data are collected and recorded as clinical data. According to the drug interaction prediction method based on the multi-dimensional features, through ensemble learning and model fusion, by means of complementary advantages of different models, reasonable screening and weighted features, the models can keep relatively stable performance in different data sets and application scenes, model prediction deviation caused by data fluctuation or feature change is reduced, and the prediction accuracy of drug interaction is improved. The generalization ability of the model is enhanced, the applicability and reliability of the model in actual drug interaction prediction are improved, and the probability that a single model generates a false positive result is reduced.

The invention discloses an intelligent medicine cabinet and a medicine fine management control system of the intelligent medicine cabinet, the device can store different medicines, the medicines can be stored in different areas while being stored, meanwhile, corresponding clamping structures are arranged to adaptively clamp and place the medicines, and the medicines are convenient to store; besides, the structure in the device is provided with multiple layers, a corresponding code scanning area is arranged in each layer of structure for code scanning verification, multiple verification is carried out through shelf codes, goods allocation codes and medicine codes, and medicine taking and placing are carried out; the problems of difficult medicine warehouse checking and difficult inventory management can be solved in an electronic mode.

The invention belongs to the technical field of graph neural network models, and particularly relates to a drug-disease association prediction method based on layered negative sample sampling. According to the method, node information is iteratively updated by using a graph convolutional network and a graph attention network, and neighborhood features and neighbor interaction features in drugs and disease similar networks are comprehensively considered in combination with a disease-drug association network. For the generated sample information, the method adopts a layered structure sampling technology, and a reliable negative sample drug-disease pair is constructed by combining a PageRank algorithm and a GAT attention score; finally, the homogeneous neighborhood and heterogeneous neighborhood features are fused through comparative learning, and universal field features of drugs and diseases are obtained. In addition, case analysis is carried out on Parkinson's disease and Alzheimer's disease, and the effectiveness of the method is verified through an authoritative data set of public literatures, clinical data, DugBank and DugCentral.

The invention discloses a medicine taking method and device for a medicine warehouse, electronic equipment and a storage medium thereof.The medicine taking method comprises the following steps that when it is detected that medicine storage boxes are stored in a medicine storage box cache area, the state is that no task exists, and a mechanical arm is idle, the mechanical arm is controlled to start taking medicine from the medicine storage boxes in the medicine storage box cache area; when it is detected that no medicine storage box is stored in the medicine storage box cache region, a target medicine storage box of the medicine to be taken is obtained from the medicine storage region, and the target medicine storage box is conveyed to the medicine storage box cache region; and when it is detected that medicine taking of the medicine storage boxes in the medicine storage box cache area is completed, the state of the medicine storage box cache area is changed into the non-task state. According to the medicine taking method, the medicine taking efficiency can be greatly improved.

The present invention provides a method and device for arranging a medicine storehouse, the method comprising the following steps: obtaining multiple drug types stored in the medicine storehouse and the total quantity corresponding to each drug type; when the total quantity corresponding to any target drug type is less than a first preset threshold, obtaining a plurality of medicine baskets to be merged whose drug type is the target drug type and whose drug quantity is less than a second preset threshold, and performing the following first processing on each medicine basket to be merged: the number of drugs in the medicine basket to be merged is Num1, obtaining a first target medicine basket whose drug type is the target drug type, and the number of drugs in the first target medicine basket + Num1 ≤ Num2, and conveying all drugs in the medicine basket to be merged to the first target medicine basket. Thus, some empty medicine baskets can be freed up.

The application discloses a medical institution drug store medicine maintenance method based on 'three-three-four' segmented logic, belongs to the field of medicine management and maintenance in medical institutions, and comprises setting a total maintenance period T and dividing into three linking stages according to the proportion of 0.3T, 0.3T and 0.4T, calculating the in-store days of the inventory medicines, performing logical comparison screening and descending arrangement, constructing a to-be-maintained batch set, extracting the batches of the first 30%, the middle 30% and the remaining 40% in each stage to generate electronic maintenance tasks, and linking PDA terminal scanning of store location labels to perform checking. Through the management mode based on the time axis segmentation driving and the in-store day dynamic filtering, the maintenance tasks can be evenly distributed, the contradiction between the maintenance of the backlog varieties and the newly-in-stored varieties is solved, the single work intensity is reduced, and the balanced maintenance of the whole process of the drug store and the GSP specification compliance are ensured.

The invention discloses a medicine dispensing method and device for a medicine warehouse, and the method comprises the following steps: obtaining the storage positions of all medicines, and obtaining a to-be-dispensed medicine list which comprises a plurality of to-be-dispensed medicines; a medicine taking path of the trolley is generated, the medicine taking path is composed of a plurality of roads connected end to end, each medicine to be dispensed is stored in a node, and the common storage position between every two connected roads is marked as the node; and the trolley is controlled to move along the medicine taking path, and in the moving process, if it is determined that congestion occurs in the medicine taking path of the trolley, a new medicine taking path is planned for the trolley again. The drug dispensing method can automatically dispense drugs.

1. The name of the design product: medicine management cabinet (2). 2. The use of the design product: used for closed-loop management of medicines in medical institutions, pharmacies, operating rooms, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: front view.

The invention relates to the technical field of medicine supply chains, in particular to a medicine supply chain optimization system which comprises the steps that the search quantity of disease keywords is captured on a social platform and a search platform, and meanwhile, the search quantity of searched IPs located in a preset area is counted; capturing sales data and inventory data of drugs in the predetermined area; acquiring various diseases searched in the predetermined area, and determining the types of medicines required to be prepared for each disease by a doctor; judging the growth rate of the search quantity of the ith disease, calculating the stock quantity of the ith disease, and notifying the medicine library to replenish goods; according to the method, the search quantity of the disease keywords is captured from the social platform and the search platform, and the first affair of modern people who suffer from illness is mainly to search diseases and corresponding diseases through the social platform and the search platform, so that the search quantity of the diseases can be mastered at the first time, and then the medicine supply chain is adjusted; the timeliness can be ensured, and the response capability is improved.

The invention discloses a processing method for an in-hospital logistics information system based on unified drug coding, and relates to the technical field of in-hospital logistics information processing. The technical scheme thereof mainly includes: constructing a unified drug coding knowledge base and a drug supply enterprise code base, and automatically generating a storage entry form after scanning the invoice issued by the drug supply enterprise or the two-dimensional code printed on the accompanying document through the hospital intranet; generating a procurement plan two-dimensional code through the hospital intranet, and uploading it to the drug supply enterprise through external network scanning; establishing a multi-level drug warehouse for the hospital drug warehouse, various pharmacies, equipment in the pharmacy, spare emergency drugs at the nurse station, and an intravenous preparation center, and the inventory drug data table, drug detail data table, etc. of each drug warehouse and their data storage and reading mechanisms are the same, and the data table name is related to the drug warehouse ID and the drug ID; the storage and procurement plans between the drug warehouses are mutually the data sources; the doctor's order data is traced back through the doctor's order status; and the drug procurement plan / drug replenishment plan is formulated according to the use of the doctor's order drugs.

The invention provides a hospital information management system which comprises system software, the system software is installed in a system terminal and runs in the system terminal, and the system software comprises medical insurance directory management, operation management, system management, archive management, medicine warehouse management, pharmacy service, outpatient service, hospitalization service, medical record management, medical insurance service and report query. By establishing the hospital information management system, various information of a hospital can be accurately recorded, doctors and patients can more trust data in the system, wrong medical decisions based on wrong data are avoided, people can accurately find the information through the system, projects can be audited, the progress of the projects can be followed, functions are diversified, and the system is convenient to use. The device is suitable for hospitals.

This invention provides a method for predicting antidepressant drugs. Based on a combination of knowledge graph, transcriptomics, and machine learning technologies, it screens potential drugs for depression. Specifically, it integrates disease-related node files, relation files, and transcriptomic data to construct information in triplet form, which is then imported into a model and converted into digital tensor information for scoring. The training dataset includes antidepressant tags from ClinicTrials and DrugBank, as well as other non-antidepressant drugs, combined with differential gene expression data obtained using RNA-seq technology. Multiple scoring models, such as TransE, TransR, DistMult, and ComplEx, are used for training and evaluation to screen potential antidepressant drugs. This method has the advantages of low cost, high efficiency, and wide applicability, significantly improving the accuracy and efficiency of antidepressant drug screening, providing a new drug discovery pathway for the treatment of depression, and helping to accelerate the research and development process of antidepressant drugs.

The invention provides application of malavirol in preparation of a medicine for treating osteoporosis, a malavirol sustained-release system and application of the malavirol sustained-release system, and relates to the technical field of medicines. The research of the inventor finds that malaviif restores the damaged macrophage intercellular function caused by OVX, removes apoptotic cells and reduces the release of inflammatory factors by antagonizing a CCR5 receptor and inhibiting the activation of a downstream signal channel of the CCR5 receptor, so that the inflammatory microenvironment in a marrow cavity is relieved, the bone homeostasis is recovered, the overexpression of osteoclasts is inhibited, and the osteoclast effect is improved. The composition is used for treating osteoporosis. According to the malaviif sustained release system provided by the invention, a drug library can be formed through subcutaneous injection, continuous release of malaviif is realized, the clinical compliance problems that the half-life period of malaviif is short and frequent administration is needed are solved, and a preferable medication scheme is provided for chronic disease management.

The utility model discloses a variable irregular shape automatic medicine storage and taking device, including sectional material frame, lift platform, medicine tray and medicine storage basket, sectional material frame supports lift platform, and lift platform is installed on lift platform frame, and the goods shelves of sectional material frame place medicine tray in order, and the medicine tray that is taken out is placed at lift platform frame, and servo motor and drive motor are arranged in lift platform, and servo motor drives transmission shaft through first synchronous pulley, and transmission shaft end installs driving synchronous pulley, and driving synchronous pulley is located in the lift synchronous belt, and the sectional material frame above medicine tray is installed with tray proximity switch, and drive motor passes through synchronous belt, and the synchronous pulley in synchronous belt is coaxially installed on bearing seat, and lift platform both sides tray support plate slide rail. The device is designed through vertical lift platform and adjustable height goods shelves, realizes the full process automation of medicine storage, medicine taking, information management, and is suitable for hospital pharmacy, wisdom medicine warehouse and the like scene.

This invention discloses a method for automatically generating pharmacy outbound tasks based on a driver-driven approach, belonging to the field of pharmaceutical logistics management. It includes receiving and aggregating drug shortage requests from various pharmacies, calculating the proportion of drug shortages reflecting replenishment urgency, and then collecting inventory attributes such as drug unit price, days in stock, and expiration date. Priority scores are calculated by combining weighted factors of 50% for the proportion of drug shortages, 30% for expiration date or stocking time, and 20% for the unit price. When generating tasks, the system follows the principles of prioritizing expiration date, consistent unit price, and stocking time, and performs sub-task splitting for batches with different unit prices to solve the problem of confusing unit price management at the pharmacy level. The generated tasks are proactively pushed to mobile devices or smart shelves with gravity sensors, utilizing automatic weight and quantity conversion to achieve closed-loop management of accurate picking monitoring, anomaly alarms, and automatic inventory verification. This invention realizes intelligent driving of replenishment tasks, reduces the risk of manual omissions, and improves picking accuracy and management efficiency.

The application discloses a medicine taking method and device for a medicine cabinet, an electronic device and a storage medium thereof. The medicine taking method comprises the following steps: when it is detected that a medicine storage box is stored in a medicine storage box buffer area, and the state is no task and the mechanical arm is idle, the mechanical arm is controlled to start taking medicine from the medicine storage box in the medicine storage box buffer area; when it is detected that no medicine storage box is stored in the medicine storage box buffer area, a target medicine storage box of a medicine to be taken is obtained from a medicine storage area, and the target medicine storage box is transported to the medicine storage box buffer area; when it is detected that the medicine storage box in the medicine storage box buffer area has completed taking medicine, the state of the medicine storage box buffer area is no task. The medicine taking method can greatly improve the medicine taking efficiency.

The invention discloses a screening method and application of a CDK12 agonist, and belongs to the field of medicine and health. The screening method comprises the following steps: acquiring a CDK12 / CyclinK compound model from a database, and optimizing the CDK12 / CyclinK compound model as a target protein for molecular docking; two binding pockets of the CDK12 are selected; screening drug-like compounds from the multi-source compound library, docking the drug-like compounds with two binding pocket networks, and screening the compounds according to pocket binding energy; calculating a valley similarity coefficient between the compounds, carrying out clustering analysis, and respectively screening out clustering compounds for the two binding pockets; identifying a RugBank source drug from the clustering compound, carrying out molecular docking and ADMET property evaluation on the RugBank source drug, and screening out preferential candidate drugs from the two binding pockets respectively; and carrying out molecular dynamics simulation on the preferential candidate drugs, screening out candidate compounds according to docking scores and binding free energy aiming at two binding pockets, carrying out cell experiment verification, and screening out the CDK12 agonist.

An infusion pump system and method with multiple drug library editor source capability including: an infusion pump system having a first drug library editor operable to generate a first drug library; a second drug library editor operable to generate a second drug library; and an infusion pump operable to connect to either one of the first drug library editor and the second drug library editor, the infusion pump having an operational drug library being one of the first drug library received from the first drug library editor and the second drug library received from the second drug library editor. The first drug library editor is one of a dedicated drug library editor and an enterprise drug library editor, and the second drug library editor is the other of the one of the dedicated drug library editor and the enterprise drug library editor.

The utility model discloses an interlayer type goods shelf and medicine storehouse relates to medicine storehouse field, including first movable frame and support plate, the one side of first movable frame is provided with second movable frame, and the side face of first movable frame and the side face of second movable frame are both fixedly connected with arc-shaped connecting block, and the arc-shaped connecting block is rotatablely connected with separating shelf. According to the interlayer type goods shelf and the medicine warehouse, by arranging the arc-shaped connecting blocks and the storage assemblies, in the use process of the medicine warehouse, the goods shelf is folded and stored, space congestion caused by the fact that the unfolded idle goods shelf occupies much space is avoided, the space is more orderly, workers can conveniently move and carry the goods shelf in the follow-up process, and the practicability of the goods shelf is improved. And meanwhile, dehumidification and insect expelling treatment is conducted on the interior of the medicine warehouse, the situation that the environment is humid or insects and mice enter the medicine warehouse to damage the medicine is avoided, the medicine is protected, certain economic losses are reduced, and the worker can conveniently use the medicine warehouse.

The invention discloses an automatic dispensing system for Chinese medicine prescriptions, including several three-dimensional medicine warehouses and a dispensing table, a medicine box moving mechanism is arranged between the three-dimensional medicine warehouse and the dispensing table, a medicine box switching device is arranged between the dispensing table and the medicine box moving mechanism, the three-dimensional medicine warehouse is composed of a shelf and a plurality of medicine boxes, the medicine boxes are provided with identification marks capable of storing and reading information, the three-dimensional medicine warehouse is provided with a stacking mechanism, and the adjustment table includes a frame, a control console arranged on the frame, several material-collecting windows, a total weighing table for weighing medicines, a main display for receiving prescriptions and displaying relevant information, and a medicine box information display for displaying the medicine box information after reading the medicine box information in the current material-collecting window. Automated operation is adopted in the entire feeding process, which requires fewer personnel and has lower requirements on personnel quality; improves the working environment and reduces personnel mobility; has low difficulty in operation, is quick to get started, reduces manual errors and loss of medicinal materials, and improves the traceability of prescription dispensing.

The application discloses a medicine taking method and device for a medicine cabinet, an electronic device and a storage medium thereof. The medicine taking method comprises the following steps: when a storage box buffer area has a storage box, a mechanical arm is controlled to take medicine from the storage box in the storage box buffer area, and a medicine taking task corresponding to taking medicine information is completed; at the same time, a storage box is placed into another storage box buffer area. Therefore, the medicine taking speed is greatly improved.

The invention belongs to the technical field of drug target screening, and particularly relates to screening and application of a streptococcus suis serine protein kinase inhibitor. Based on a chemiluminescence technology, a possible HPrK inhibitor is screened out by determining luminescence values of different drugs added into a reaction system, and the reaction system comprises streptococcus suis SC19 serine protein kinase (HPrK), streptococcus suis SC19 phosphorylated carrier protein (HPr), ATP, a kinase reaction buffer solution and # imgabs0 # Reagent. The inhibitor CDK9-IN-2 is obtained by screening a kinase inhibitor drug library, the inhibition rate of the inhibitor CDK9-IN-2 on streptococcus suis serine protein kinase (HPrK) reaches 99%, and the inhibitor CDK9-IN-2 also has an obvious inhibition effect on staphylococcus aureus, mycoplasma hyorhinis and the like.

The invention discloses a medicine taking method and device for a medicine warehouse, electronic equipment and a storage medium, the medicine taking method comprises the following steps: receiving medicine taking information, the medicine taking information comprising row numbers and column numbers of a plurality of target medicine storage positions in a target medicine basket; a target medicine basket is obtained from the first medicine storage frame or the second medicine storage frame and conveyed to a medicine taking area, a mechanical arm is controlled to stretch into the position above the medicine taking area, a camera is controlled to shoot the target medicine basket, and a target picture is obtained; when the target medicine basket is obtained from the first medicine storage frame, medicine storage positions of M rows and N columns are recognized from the target picture, and each medicine storage position is processed as follows: X = M + 1-the row number of the medicine storage position, Y = N + 1-the column number of the medicine storage position, the row number of the medicine storage position is modified to be X, and the column number of the medicine storage position is modified to be Y; and then, based on the line number and the column number of each target medicine storage position, a manipulator is controlled to grab the medicine on the target medicine storage position. The manipulator can accurately take medicine from the medicine basket.

The application discloses a kind of based on medical institution pharmacy consumption and trend automatic generation of drug shortage method, belong to medical institution drug management and logistics field, it includes setting statistical cycle acquisition actual consumption, and generate daily predicted consumption with moving average algorithm and the rise trend of same ratio and ratio comparison.The system synchronously pulls pharmacy and drugstore real-time inventory, calculates the amount of drug shortage based on predicted value, dynamically calculated safety stock and current amount, and automatically generates a request list when reaching the minimum distribution threshold.Then, the list is sorted intelligently according to expiration date, procurement cost and supplier factors and actively pushed to the mobile end.After the goods are delivered, the system uses the actual data and turnover days calculated from the feedback to optimize the parameters of the prediction model and the safety stock coefficient in a closed loop iteration.The application realizes the precision and automation of drug supply through data-driven replenishment logic, which reduces the risk of supply interruption and inventory accumulation while ensuring clinical supply.

The invention discloses a medicine storage method and device for a medicine warehouse, and the method comprises the following steps: obtaining a plurality of collar lists and all types of medicines in all collar lists, and dividing all medicines into a plurality of types; each class corresponds to a medicine storage area, and carrying out the following treatment on each class: continuously optimizing the medicine storage devices corresponding to the core medicines in the class until the sum of the distance measurement values corresponding to any two core medicines is minimum, the distance measurement value = the distance between the medicine storage devices corresponding to the two core medicines * the corresponding correlation degree * the sum of the priorities corresponding to the two core medicines, and then putting the core medicines into the corresponding medicine storage devices. According to the medicine storage method, the storage positions of various medicines can be reasonably planned, and the walking distance in the medicine taking process is reduced, so that the medicine taking efficiency is improved, the labor intensity is reduced, and the medicine taking timeliness and accuracy are guaranteed.

The invention discloses a medicine taking method and device for a tablet medicine warehouse, a storage medium and a terminal, and the method comprises the following steps: obtaining a target prescription which comprises the name and the number of target medicines; based on the target prescription, the medicine taking unit is controlled to take target medicines, and all the target medicines are conveyed to a packaging area; and the packaging area is controlled to package all the target drugs and convey the target drugs to a drug outlet. By optimizing the medicine taking process, improving cache management and improving the automation degree of the medicine taking units, efficient and accurate medicine distribution is achieved, movement of the medicine taking units can be accurately controlled, waiting time and repeated operation are reduced, the medicine taking speed is increased, the system is suitable for an automatic plate medicine warehouse, and the operation efficiency and the patient satisfaction degree of the plate medicine warehouse are improved.

The application discloses a medicine taking method and device for a medicine cabinet, electronic equipment and storage medium. The medicine taking method comprises the following steps: receiving medicine taking information, the medicine taking information comprising: the row number and column number of a plurality of target storage positions in a target medicine basket; obtaining the target medicine basket from a first medicine storage rack or a second medicine storage rack and conveying it to a medicine taking area; controlling a mechanical arm to extend above the medicine taking area; controlling a camera to take a picture of the target medicine basket and obtaining a target picture; when the target medicine basket is obtained from the first medicine storage rack, identifying M rows and N columns of storage positions from the target picture, and performing the following processing on each storage position: X = M + 1 - the row number of the storage position, Y = N + 1 - the column number of the storage position, modifying the row number of the storage position to X, and modifying the column number of the storage position to Y; then, based on the row number and column number of each target storage position, controlling the mechanical arm to grasp the medicine on the target storage position. The mechanical arm can correctly take medicine from the medicine basket.

1. The name of the product of this design: Intelligent drug management cabinet (narcotic fentanyl). 2. Purpose of this design product: This design product is mainly used for closed-loop management of fentanyl drugs in medical institutions’ drug warehouses, pharmacies, operating rooms, etc. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture. 5. Other situations that require explanation Other explanations: Part A is made of transparent material.

This invention discloses a control method, device, computer equipment, and storage medium for a medicine basket storage cabinet. The control method includes the following steps: receiving a prescription to be dispensed, the prescription containing the types of medicines and the corresponding quantities for each type; controlling a basket storage device to sequentially grab a target medicine basket and send it into a medicine basket transport device; then, obtaining a unique identification code for the target medicine basket and binding the identification code to the prescription to be dispensed; based on the prescription to be dispensed, controlling the pharmacy to dispense medicines to the target medicine basket located in the medicine basket transport device, and when the dispensing is completed, controlling the medicine basket transport device to transport the target medicine basket onto a first conveyor belt; selecting a target medicine basket rack, controlling the first conveyor belt to transport the target medicine basket to the target medicine basket rack; controlling the target medicine basket rack to transport the target medicine basket to an empty medicine basket storage position. This achieves automatic receipt of medicines and placement into medicine baskets, and then placing the full medicine basket into a medicine basket storage position.

The application belongs to the technical field of drug target screening, and particularly relates to screening of a streptococcus suis serine protein kinase inhibitor and application thereof. Based on a chemiluminescence technology, possible HPrK inhibitors are screened by measuring luminescence values of different drugs added in a reaction system, and the reaction system comprises streptococcus suis SC19 serine protein kinase (HPrK), streptococcus suis SC19 phosphorylated carrier protein (HPr), ATP, a kinase reaction buffer and Reagent. By screening of the kinase inhibitor library by using the application, an inhibitor CDK9-IN-2 is obtained, the inhibition rate of the inhibitor CDK9-IN-2 to the streptococcus suis serine protein kinase (HPrK) reaches 99%, and the inhibitor CDK9-IN-2 also has obvious inhibitory effects on staphylococcus aureus, mycoplasma hyosynovis and the like.