43 results about "DrugBank" patented technology

An infusion pump system and method with multiple drug library editor source capability including: an infusion pump system having a first drug library editor operable to generate a first drug library; a second drug library editor operable to generate a second drug library; and an infusion pump operable to connect to either one of the first drug library editor and the second drug library editor, the infusion pump having an operational drug library being one of the first drug library received from the first drug library editor and the second drug library received from the second drug library editor. The first drug library editor is one of a dedicated drug library editor and an enterprise drug library editor, and the second drug library editor is the other of the one of the dedicated drug library editor and the enterprise drug library editor.

A pharmacy robot device comprises a chassis, a pharmacy, push rod equipment, a conveyor belt and an induction door, and is used for executing the functions of drug replenishment, delivery and inventory, and an AI verification system and an intelligent diagnosis system are combined to realize physician service, pharmacist service and pharmaceutical affair service of the pharmacy. According to requirements, a plurality of pharmacy robot devices can be linked in parallel or in series, the variety and number of stored drugs are increased, the device is simple in structure and flexible to deploy and configure, and therefore, the operation cost of a pharmacy shop is reduced.

An implantable shock electrode line having a proximal terminal for connection to an implantable defibrillator, an elongated flexible line body, and a shock electrode and a drug delivery device arranged at or near the distal end of the line body. A drug depot connected to the drug delivery device is provided in the shock electrode line, and the terminal is designed as a purely electric standard terminal. The drug delivery device is designed for control by an electric pulse transmitted over the electric terminal to the shock electrode line.

The invention relates to a method for screening hypoglycemic active components of cornus officinalis. The method comprises the following steps of: establishing a cornus officinalis aqueous extract component analysis method by using a chromatography-mass spectrometry technology, and identifying active components in cornus officinalis through data analysis; carrying out similarity comparison on chemical structures of the active components and a DrugBank database, and setting a similarity scoring card value to be 0.8 so as to obtain a component target; retrieving a disease / syndrome target database to obtain candidate disease targets of diabetes; carrying out related hypoglycemic effect target prediction on the chemical components of the cornus officinalis by adoption of a network pharmacologic technology, constructing a cornus officinalis component-hypoglycemic target-role access network, and predicting potential hypoglycemic active components and a molecular mechanism; and carrying out activity evaluation and experimental verification on the potential active components through cell experiment so as to determine real and effective hypoglycemic active components in the cornus officinalis. The method is capable of improving the cornus officinalis active component screening efficiency and reducing the drug active component screening cost.

The invention relates to a transdermal drug delivery system having a structure with two layers namely a drug storage layer and a sticking layer. The drug is stored in the drug storage layer in an over-saturated state. The matrix materials of the drug storage layer and the sticking layer are chosen from polyacrylate, polysiloxane and polyisobutylene, and are not the same material at the same time. The transdermal drug delivery system can realize the constant drug releasing.

The invention discloses a preparation method of a clonidine controlled-release patch. The preparation method specifically includes: weighing active ingredients including clonidine and polybutene pressure-sensitive adhesive, mixing the active ingredients well to form a pasting layer, coating the pasting layer on an anti-adhesion layer, and pasting the pasting layer and a controlled-release layer together after drying; weight the active ingredients including clonidine and polybutene pressure-sensitive adhesive, mixing the active ingredients well to form a drug storehouse layer, coating the drug storehouse layer on a back lining layer, and pasting the drug storehouse layer and the controlled-release layer together after drying; uniformly slitting an obtained production into 1000 pieces, sterilizing, and packaging. The clonidine controlled-release patch has the advantages of safety and reliability.

The invention discloses a regional collaborative linkage medication management method and system based on an NFC visual smart card. The system disclosed by the invention comprises a collaborative medical platform, a smart drug library system, a hospital management information system, a family doctor subsystem and a patient subsystem, which can separately perform information interaction with the visual smart card. The method comprises the following steps: writing prescription information into the visual smart card at the hospital management information system or through the collaborative medical platform, and using the visual smart card to trigger an electronic label at a position of a smart drug library corresponding to the medicine in the prescription information at the smart drug librarysystem to send medicine withdrawal prompt, and after the medicine withdrawal is completed, performing, the visual smart card and the electronic label, delivery information, and uploading a patient medicine withdrawal record to the collaborative medical platform. During the medication treatment of a patient, the medication effect information is uploaded to the collaborative medical platform through the smart card, the family doctor subsystem and the patient subsystem.

The invention discloses an automatic traditional Chinese medicine prescription dispensing system. The automatic traditional Chinese medicine prescription dispensing system comprises a plurality of three-dimensional medicine storages and a dispensing table, wherein a medicine box moving mechanism is arranged between the three-dimensional medicine storages and the dispensing table, a medicine box switching device is arranged between the dispensing table and the medicine box moving mechanism, each three-dimensional medicine storage is composed of a storage rack and a plurality of medicine boxes,identification marks capable of storing and reading information are arranged on the medicine boxes, the three-dimensional medicine storages are provided with stacking mechanisms, and the dispensing table comprises a rack, a control table arranged on the rack, a plurality of taking windows, a general weighing platform for weighing medicines, a main display for receiving prescriptions and displayingrelated information, and a medicine box information display for reading and then displaying medicine box information in the current taking window. Automatic operation is adopted in the whole feedingprocess, so that personnel requirements are less, and personnel quality requirements are lower; the working environment is improved, and the mobility of personnel is reduced; the operation difficultyis low, the mastering speed is high, the manual error and the loss of medicinal materials are reduced, and the traceability of prescription dispensing is improved.

The invention relates to an FM-N-DNN-based drug and target interaction prediction method. The method comprises the following steps of: S1, obtaining drug and target interaction pairs from a DrugBank database and marking the drug and target interaction pairs as a positive samples; S2, dividing the drug and target interaction pairs into different drugs and targets and then forming an independent drug group and an independent target group; randomly selecting drugs and targets from the drug group and the target group to construct new drug and target interaction pairs, and marking samples which arenot positive samples in the newly constructed drug and target interaction pairs as negative samples; S3, extracting feature vectors of the positive samples and the negative samples by utilizing an open source python software package PyDPI; S4, preprocessing the feature vectors extracted in the step S3; S5, constructing an FM-N-DNN model and training the FM-N-FNN model by utilizing the feature vectors of the positive samples and the negative samples; and S6, predicting a drug and target interaction by utilizing the trained FM-N-DNN model.

The invention discloses an intelligent fever cooling patch. The intelligent fever cooling patch comprises a backlining layer, a water retention layer fixed to the backlining layer, a drug storage layer used for storing cooling liquid, an infusion device used for controlling the cooling liquid in the drug storage layer to flow to the water retention layer, an automatic detection starting device serving as a switch according to body temperature, and an alarm device used for sending out an alarm signal. The infusion device is connected with the drug storage layer, the automatic detection starting device is electrically connected with the infusion device, and the alarm device is electrically connected with the automatic detection starting device. Compared with traditional fever cooling patches, the intelligent fever cooling patch has the advantage that the automatic detection starting device and the infusion device are matched for infusion, when the automatic detection starting device detects that temperature reaches a set value of the automatic detection starting device, the alarm device gives an alarm to draw attention of parents, and at the same time, the infusion device starts to deliver the cooling liquid in the drug storage layer to the water retention layer to improve the cooling effect.

A medicine management apparatus includes: a medicine storage (11); a tag detection unit (14) which detects (i) worker information for identifying a worker and a work position of the worker and (ii) worker information and a work position of a worker who is present in the first work area and worker information and a work position of a worker who is present in the second work area; a management unit (22) which determines, based on a result of the detection performed by the tag detection unit (14), whether or not an unlocking condition is satisfied, which is (i) plural workers who are authorized to use the medicine storage (11) are present in an area that is a combination of the first work area and the second work area and (ii) at least one of the workers is present in the first work area, in the state where the medicine storage (11) is locked, and a lock unit (13) which sets the medicine storage (11) to a state which allows the medicine storage to be unlocked, when it is determined, by the management unit (22), that the unlocking condition is satisfied.

A patch injector (10) for parenteral administration of a drug to a drug recipient has a drug-cartridge module (14) attached to a power-pack module (12) and to a drug-recipient interface module (16). A compressed, elastic power element (18) disposed in the power-pack module (12) is coupled to a plunger (30) movably disposed in a drug reservoir (22) in the drug-cartridge module (14). An injection needle (24) at the distal end of the drug reservoir (22) is oriented orthogonal to the drug reservoir (22) and generally toward a skin-contact surface (28) extending parallel to the longitudinal drug-reservoir axis (22A). The power element (18) is configured to displace the plunger (20) distally into the drug reservoir (22) and to move the injection needle (24) toward the skin-contact surface (28) when the power element (18) expands distally along the drug-reservoir axis (22A).

The invention discloses an online prescription extraction system and method based on a WeChat official account, and belongs to the technical field of clinic prescription extraction. The system comprises a nurse module, a doctor module, a pharmacist module, a pharmacy and medicine library module, a charging module and a setting module; the nurse module is used for registering patient information and executing patient items; and the doctor module is used for checking a waiting queue, an electronic medical record, making an examination, making a prescription, making a treatment and completing the diagnosis. According to the online evolution system and method based on the WeChat official account, the problems of diagnosis and treatment processes, file management, internal management, external marketing, popularization, customer acquisition and the like of clinics are solved with lower cost, the digital management level of primary medical institutions is comprehensively improved, and the functions cover the whole workflow of medical staff and managers; an Alicloud deployment mode is adopted, clinics can enjoy intelligent SAAS management system services without purchasing hardware, and functional applications in three aspects of internal process optimization, external expansion and medical technology support are obtained.

A medicament latent adverse reaction discovery method based on a neural network language model relates to the field of a medicament latent adverse reaction discovery method. The method comprises the following steps of performing data acquisition and cleaning; performing model optimization, modifying an original Skip-gram algorithm for performing characteristic extraction from the AERS report of the FDA and the DrugBank DDI dataset; extending an interaction database, selecting 5 adverse reactions kinds: kidney damage, heart toxicity, liver toxicity, blood pressure abnormity and neurotoxicity, using the five adverse reaction kinds as a Logistic regression verifying medicament and adverse reaction vector range and extending a DrugBank medicament interaction database in the range of the five kinds; performing Logistic regression and verifying a vector effect, finishing CM-TF-IDF model construction and distributed vector generation by means of Scikit-learn. The medicament latent adverse reaction discovery method based on the neural network language model settles the following problems in an existing method: relatively low data processing speed, unsuitability for processing large-scale data set and incapability of quickly performing characteristic learning.

The invention discloses a method of the unmanned intelligent pharmacy comprises the steps of unmanned pharmacy deployment, medical service robot configuration, unmanned operation, unmanned physician service, pharmacist service, medicine service and health service providing; flexible setting and wide connection with customers are achieved by means of an unmanned drug library, an unmanned equipment library and an unmanned service system; and medical health services are provided for 24 hours of the whole day in the region.

The invention discloses an intelligent medical medicine monitoring and early warning system, which comprises a first-aid medicine management cloud data center which is used for first-aid medicine datastorage and log storage, and is used for data tracing and management in the future; a pharmacy department first-aid medicine management terminal used for receiving and sending first-aid medicines, printing bar codes, recovering the first-aid medicines and intervening expiration date; a pharmacy department first-aid medicine intelligent management and reminding terminal, which allows pharmacy or medicine storehouse personnel to conveniently check the validity period of all first-aid medicines and the positions and the number of the medicines; and an inpatient area first-aid medicine managementterminal which allows inpatient area nurses to count the medicine conveniently. According to the intelligent medical medicine monitoring and early warning system, the shortage degree of various medicines can be accurately pre-judged in time so as to ensure that the various medicines are not in shortage as much as possible, and thus delay of disease treatment of a patient is avoided; and the utilization rate of the medicine can be improved as much as possible, and waste of some surplus medicine due to expiration date exceeding is avoided.

The invention provides a medicine discharging method and device of a medicine storehouse, the medicine storehouse and a storage medium. The medicine discharging method comprises the steps: obtaining aplurality of prescriptions which comprise a plurality of medicine types and the number of dispensed medicines corresponding to each medicine type; obtaining a plurality of to-be-supplemented medicinetypes from the plurality of prescriptions, the total storage amount of each to-be-supplemented medicine type in the medicine dispensing equipment being smaller than the sum of the medicine dispensingamounts of the to-be-supplemented medicine type in the plurality of first prescriptions; performing the following operations on each to-be-supplemented medicine type: obtaining medicines corresponding to the to-be-supplemented medicine types from a second-level library and storing the medicines into the medicine dispensing equipment, so that the sum of the medicine dispensing quantities of the to-be-supplemented medicine types in the plurality of prescriptions is less than or equal to the total storage quantity of the to-be-supplemented medicine types in the medicine dispensing equipment; andcontrolling the medicine dispensing equipment to complete the medicine dispensing operation of the plurality of prescriptions. It can be understood that according to the medicine discharging method,the medicines are not discharged according to the sequence of the prescriptions one by one, but multiple prescriptions are discharged at the same time, and therefore, the work efficiency of the medicine storehouse can be improved.

The invention relates to a molecular virtual screening method based on protein sequence alignment, which comprises the following steps: according to an input protein sequence to be subjected to molecular screening, acquiring multi-sequence coupling information of protein by using an HHbits program; the frequency PSFM of the same residues appearing at the corresponding positions of the protein sequence to be predicted and the multi-sequence coupling information being calculated; by using the same method, generating the PSFM of each protein sequence in a protein-ligand interaction database BioLiP; calculating the residue alignment score and similarity matching quality of the to-be-predicted protein and each protein in BioLiP, and obtaining a potential seed molecule set according to the matching quality score; and calculating the sum of the two-dimensional fingerprint values of each molecule in the molecule database and all the molecules in the seed molecule set, sorting all the molecules in the DrugBank according to scores, and obtaining x.NDrugBank molecules with the top scores as a molecular sieve selection set of protein sequences to be subjected to molecular screening. The method can be used for any screening scene.

According to the drug inventory cardinal number adjusting system and the drug inventory cardinal number adjusting method, the types and the number of the drugs called into the target drug library are determined according to different target drug library types and different drug types (standing drugs, seasonal drugs and special drugs), dynamic adjustment of the drug library inventory is achieved, the hospital drug management efficiency is improved, timely supply of drugs is guaranteed, the drug turnover rate is increased, drug inventory backlog is reduced, and the hospital drug storage cost is reduced.

The invention discloses a medicine sorting method and device for a medicine warehouse, the medicine warehouse and a storage medium. The medicine sorting method comprises the steps that it is detectedthat medicines are put into a medicine inlet; N prescriptions corresponding to a plurality of medicine distribution openings in a sorting machine are obtained, M prescriptions lacking the medicines are obtained from the N prescriptions, and the target prescriptions are selected from the M prescriptions, where N and M are natural numbers and M is less than or equal to N, the prescriptions are usedfor recording a plurality of medicines which medicine baskets, in one-to-one correspondence with the prescriptions, lack and the lacking number corresponding to the medicines, the prescriptions are inone-to-one correspondence with the medicine distribution openings, and in the M prescriptions, the distance between the medicine distribution openings corresponding to the target prescriptions and basket outlets is the shortest; and the sorting machine is controlled to sort the medicines out of the medicine distribution openings corresponding to the target prescriptions. According to the method,the medicine sorting efficiency can be greatly improved.

The invention discloses a drug delivery system and a drug delivery device, and belongs to the technical field of drug conveying. The drug delivery system comprises a drug taking window and a drug storehouse, the drug taking window comprises an instruction input module, a judgment module, a prescription drug name library, a proof retrieval module and a feedback module; and the drug storehouse comprises an information input module, a database, a calculation module and an extraction module, prescription drugs can be automatically judged, meanwhile, the drug taking qualification can be checked, the prescription drugs are prevented from being delivered at will, potential safety hazards are reduced, the drug storehouse can be quickly retrieved, manual retrieval is not needed, time and labor are saved, the drug delivery efficiency is improved, the drugs at the high position can be conveniently taken, and time and labor are saved.

The invention discloses a clonidine transdermal patch comprising an anti-sticking film, an adhesive layer, a controlled-release film, a drug storage layer and a backing film; the adhesive layer is coated between the anti-sticking film and the controlled-release film, the drug storage layer is coated between the controlled-release film and the backing film, colchicine in the adhesive layer and thedrug storage layer accounts for 2.5%-4% of the total amount of drugs, and other auxiliary materials account for 96%-97.5%. The clonidine transdermal patch is convenient to use; the uniformity of a drug-containing adhesive paste in the production process of the clonidine transdermal patch is improved effectively, and the problems of layering and coating thickness uniformity of the drug-containing adhesive paste in the coating process are solved effectively, and it is ensured that the clonidine transdermal patch is uniform in content and the release behavior conforms to the controlled release characteristic.

The invention discloses an integrated medicine box, which comprises a medicine groove, a driving device, a medicine discharging device and a medicine box control unit. The integrated medicine box is used for replacing a fixed medicine groove of the automatic medicine selling machine, and has the advantages that (1) when the integrated medicine box breaks down, only the broken-down integrated medicine box needs to be taken out, operation of other integrated medicine boxes of the automatic medicine selling machine is not affected, overall operation of the automatic medicine selling machine is not affected, and the daily management and operation and maintenance efficiency of the automatic medicine selling machine is greatly improved; and (2) the integrated medicine box can be integrally takenout from the automatic medicine selling machine and is filled with medicines from the outside, and the medicines are integrally put into the automatic medicine selling machine after being filled, sothat the medicines can be filled in a medicine storehouse or a safe place in a remote manner, the defect that the fixed medicine groove needs to be filled with the medicines on site is avoided, and the medicine safety is guaranteed.

A medical service resource optimization system based on multi-pharmacy collaboration technology, including a virtual drug library as a data center, which collects, stores, analyzes and uses data in a standardized manner; the computing center can schedule intelligent optimization algorithms to calculate the inventory of multiple pharmacies in real time , out-of-stock, etc., according to the patient's historical drug purchase records, etc., portray patient portraits, obtain group labels, and predict market demand; the situation awareness module obtains the patient's situation through sensors, etc., and the computing center gives "one person, one policy" personalized Service plan; the display interface provides each member with the optimal decision-making plan, such as the best place for patients to take medicine; the feedback center supports multiple ways of taking medicine, such as online ordering store pickup, online ordering store delivery, etc., and sends them to the corresponding pharmacy in real time through the panel. The invention helps to realize the service-oriented, profitable and refined pharmaceutical supply chain, optimize the allocation of medical service resources, support new medical service modes such as telemedicine, mobile medical treatment, and smart medical treatment, and improve the level of medical service in my country.

The invention discloses an intelligent GCP pharmacy management system and a medicine dispensing method. The pharmacy management system comprises nine functional modules including a medicine warehouse module, a pharmacy module, a prescription dispensing module, a recovery application module, a medicine recovery module, a medicine recovery recording module, a residual medicine disposal module, a disposed medicine module and a prescription history management module. The automatic medicine dispensing method is realized through butt joint of the intelligent medicine cabinet and the system. According to the invention, the informatization of GCP pharmacy management is realized, and an automatic medicine dispensing mode is realized through the intelligent medicine cabinet, so that the management is more systematic, efficient and standard, the medicine clinical test process is traceable, and the authority management responsibility is clear. Dispensing errors are prevented, paper operation is reduced, resource consumption and waste are reduced, and personnel allocation is reduced.

The invention discloses a method and device for sorting medicines in a medicine storehouse, a medicine storehouse and a storage medium. The method for sorting medicines includes: detecting that medicines are put into the medicine inlet; For N prescriptions corresponding to several drug distribution ports, M prescriptions lacking the drug are obtained from the N prescriptions, and the target prescription is selected from the M prescriptions, where N and M are natural numbers, and M≤ N, the prescription is used to record the number of medicines that are still missing in the one-to-one corresponding medicine basket and the missing quantity corresponding to each medicine, and the prescription is in one-to-one correspondence with the dispensing port. Among the M prescriptions , the distance between the drug dispensing port corresponding to the target prescription and the basket outlet is the shortest; the sorter is controlled to sort the medicines from the drug dispensing port corresponding to the target prescription. Thus, the efficiency of sorting medicines can be greatly improved.

The invention provides an injection dispensing system, and relates to the field of automatic equipment. The injection dispensing system comprises a dispensing information acquisition module, a dispensing information processing module, a medicine storehouse, a medicine grabbing module and a medicine transportation module, wherein the dispensing information acquisition module is used for acquiring dispensing order information and sending the dispensing order information to the dispensing information processing module; the medicine storehouse comprises a plurality of medicine storage cabinets; the dispensing information processing module stores position information of various medicines in the medicine warehouse; the dispensing information processing module is further used for receiving the dispensing order information acquired by the dispensing information acquisition module, generating type information of to-be-grabbed medicines, position information of each kind of to-be-grabbed medicines and quantity information of each kind of to-be-grabbed medicines according to the dispensing order information and sending the type information of to-be-grabbed medicines, the position informationand the quantity information of each kind of to-be-grabbed medicines to the medicine grabbing module; the medicine grabbing module is used for grabbing medicines and transporting the medicines to themedicine transportation module; and the medicine transportation module is used for transporting the medicines out of the medicine warehouse. The system has the advantages that the labor force requiredfor dispensing is reduced, and the dispensing work efficiency is improved.

The invention, which belongs to the technical field of medicines, particularly relates to application of a dendranthema morifolium extract in preparation of antitumor drugs. The dendranthema morifolium extract is shown as at least one of formula I: (6R,7R,9E)-7-hydroxy-bisabolane-2,9,11-triene-4-one and formula II:(6R,7R,9E)-7-hydroxy-11-methoxy-bisabolane-2,9-diene-4-one. The compounds of the formula I and the formula II can inhibit proliferation of Hela human cervical cancer cells in vitro and IC50 is 12.43 micrometers and 25.52 micrometers respectively; and the dendranthema morifolium extract can be used as a main component, a secondary component or an additive in an antitumor drug.The anti-tumor activity of the dendranthema morifolium is found, so that the plant can be used for medicine preparation and natural medicine library resources in China are enriched; the effect is obvious, the green and environment-friendly effects are realized; and a novel way and means are provided for treating and curing tumors.