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Medicament-supported hydrogel system and preparation method thereof

A technology for loading drugs and hydrogels, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and liquid delivery. It can solve problems such as single action form and achieve good drug sustained release

Inactive Publication Date: 2014-05-07
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the single defect of the supramolecular hydrogel drug-loading system prepared in the prior art, and provide a supramolecular hydrogel containing multiple drug action sites and containing graphene nanostructures preparation method

Method used

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  • Medicament-supported hydrogel system and preparation method thereof
  • Medicament-supported hydrogel system and preparation method thereof
  • Medicament-supported hydrogel system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This example is used to illustrate the preparation of graphene oxide aqueous solution.

[0030] Add 2 grams of fineness to 325 mesh flake graphite raw materials and 2 grams of sodium nitrate into 180 grams of concentrated sulfuric acid (98%), and cool with an ice-water bath.

[0031] While maintaining vigorous stirring, slowly add 12 grams of potassium permanganate, and control the speed of addition so that the temperature of the suspension does not exceed 20° C. (complete addition within 1 hour). Then the ice-water bath was removed, and the suspension was kept at 35±5° C. for 120 hours to obtain a brown mixture.

[0032]200 mL of deionized water was slowly added to the mixture, the temperature was raised to 98 °C and maintained at this temperature for 1 hour. The resulting suspension was then diluted to 1 L with water. Add 500 mL of 3 wt % hydrogen peroxide solution to convert the remaining potassium permanganate and manganese dioxide into manganese sulfate to obtain...

Embodiment 2

[0035] This example is used to illustrate the drug-loaded hydrogel system provided by the present invention and its preparation method.

[0036] 1) Dilute the graphene oxide aqueous solution prepared in Example 1 to 0.3 mg / mL, take 10 mL, add 900 mg of F127 (EO 106 PO 70 EO 106 ) block copolymer, stirred at 20° C. for 12 hours to obtain an aqueous solution of graphene oxide modified by the block copolymer.

[0037] 2) Add 0.6 mg of doxorubicin to 1 mL of the solution prepared in step 1), sonicate for 0.5 hours, and stir in the dark for 12 hours to obtain a drug-loaded graphene aqueous solution.

[0038] figure 1 It is the ultraviolet-visible spectrum comparison chart of the above-mentioned graphene aqueous solution before and after drug loading, wherein, curve a1 is the ultraviolet absorption curve of doxorubicin, curve b1 is the ultraviolet absorption curve of graphene, and curve c1 is the ultraviolet absorption of graphene-adriamycin Curve, curve d1 is the ultraviolet ab...

Embodiment 3

[0042] This example is used to illustrate the drug-loaded hydrogel system provided by the present invention and its preparation method.

[0043] 1) Dilute the graphene oxide aqueous solution prepared in Example 1 to 0.3 mg / mL, take 10 mL, add 900 mg of F127 (EO 106 PO 70 EO 106 ) block copolymer, stirred at 20° C. for 12 hours to obtain an aqueous solution of graphene oxide modified by the block copolymer. Add the graphene oxide aqueous solution modified by the block copolymer into the reaction kettle, and heat at 150° C. for 48 hours to obtain the reduced graphene aqueous solution modified by the block copolymer.

[0044] 2) Add 0.6 mg of doxorubicin to 1 mL of the solution prepared in step 1), sonicate for 0.5 hours, and stir in the dark for 12 hours to obtain a drug-loaded graphene aqueous solution. After the drug was loaded onto the graphene surface, the peak of the ultraviolet absorption spectrum became wider, and the intensity of the fluorescence spectrum weakened, wh...

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Abstract

The invention provides a medicament-supported hydrogel system, which comprises a block copolymer modified graphene and / or graphene oxide, medicinal molecules and cyclodextrin hydrogel. The invention also provides a preparation method of the hydrogel system. The preparation method comprises the following steps: (1) adding block copolymer into graphene and / or graphene oxide aqueous solution, and reacting to obtain the block copolymer modified graphene and / or graphene oxide aqueous solution; (2) adding the medicinal molecules into the aqueous solution prepared in the step (1), and supporting the medicinal molecules to the graphene and / or graphene oxide; and (3) adding the solution prepared in the step (2) into the cyclodextrin aqueous solution to obtain the medicament-supported hydrogel system. The hydrogel system provided by the invention has the characteristics of supramolecular hydrogel, and contains a graphene nano-structure in the gel structure, can be used for regulating the medicament releasing process, and has good medicament sustained-release effect.

Description

technical field [0001] The invention relates to a drug-loaded hydrogel system and a preparation method thereof. Background technique [0002] Supramolecular hydrogels based on cyclodextrin and block polymers have been studied in drug controlled release and targeted delivery (Li J, Loh X.Adv.Drug.Deliv.Rev.2008, 60: 1000-1017), the principle of action is to use a certain segment in the block copolymer to pass through the cavity of the cyclodextrin and form a rotaxane structure. Dextrin can form a supramolecular hydrogel system with various functions, which can be used for the delivery of drug molecules or gene delivery. The release principle is that in a large amount of release media, the block copolymer tends to dissolve in it, and then the inclusion effect with cyclodextrin is destroyed, and the gel structure decomposes. However, its single mode of action has certain limitations for the controlled release of drug molecules, and the single release process makes the release...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61K47/40A61K47/30A61K9/06A61K47/34A61K47/04
Inventor 韩宝航承倩怡
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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