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Fat-burning dredging particles and preparation method thereof

A production method and granule technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and bulk delivery, etc., and can solve the problem that there are not many young and middle-aged hyperlipidemia.

Inactive Publication Date: 2012-07-11
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many studies on traditional Chinese medicine for hyperlipidemia, and some drugs have been researched and developed into new drugs, but there are not many studies on drugs dedicated to hyperlipidemia in young and middle-aged people.

Method used

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  • Fat-burning dredging particles and preparation method thereof
  • Fat-burning dredging particles and preparation method thereof
  • Fat-burning dredging particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] Preparation method of the present invention is carried out as follows:

[0115] a. Mix and grind Curcuma 6, Fried Atractylodes 15, and Chenpi 6, pass through a No. 3 sieve, and then use CO 2 Supercritical extraction of its volatile oil, control the extraction pressure at 30Mpa, temperature at 40°C, and time for 3 hours, then use saturated aqueous solution method to carry out β-CD inclusion of volatile oil, control oil: β-CD=1:7, 55°C, inclusion Combined for 0.5 hours, refrigerated for 30 hours, filtered with suction, and evaporated to dryness naturally to obtain volatile oil β -Cyclodextrin inclusion complex, standby;

[0116] b. Get 50-70% by weight of coix seed 15 to pulverize, pass through a No. 6 sieve, and fine powder for subsequent use;

[0117] c. Crush Pinellia 15, Alisma 6, Puhuang 9, Rhubarb 6, Clematis 9, and the remaining coix seed into a coarse powder, and use the weight of the residue after supercritical extraction of volatile oil from Zezhu, fried Atrac...

Embodiment 2

[0120] Preparation method of the present invention is carried out as follows:

[0121] a. Take zedoary 12, stir-fry Atractylodes 6, and tangerine peel 12, crush them, pass through a No. 3 sieve, and then use CO 2 Supercritical extraction of its volatile oil, control the extraction pressure at 25Mpa, temperature at 50°C, and time for 2 hours, then use the saturated aqueous solution method to carry out β-CD inclusion of the volatile oil, control oil: β-CD=1:9, 45°C, inclusion Combine for 1 hour, refrigerate for 24 hours, filter with suction, evaporate to dry naturally, and get volatile oil β -Cyclodextrin inclusion complex, standby;

[0122] b. take 50-70% by weight of Coix Seed 12 to pulverize, pass through a No. 6 sieve, and fine powder for later use;

[0123] c. Grind Pinellia 9, Alisma 12, Puhuang 5, Rhubarb 9, Clematis 6, and the remaining coix seed into a coarse powder, and use the weight of the residue after supercritical extraction of volatile oil from Zezhu, fried Atr...

Embodiment 3

[0126] Preparation method of the present invention is carried out as follows:

[0127] a. Take Curcuma 9, Fried Atractylodes 10, Chenpi 9 and grind them, pass through a No. 3 sieve, and then use CO 2 Supercritical extraction of its volatile oil, control the extraction pressure at 27Mpa, temperature at 45°C, and time for 2.5h, then use the saturated aqueous solution method to carry out β-CD inclusion of the volatile oil, control oil: β-CD=1:8, 50°C, Inclusion for 0.8 hours, refrigerated for 20 hours, suction filtered, and naturally evaporated to dryness to obtain volatile oil β -Cyclodextrin inclusion complex, standby;

[0128] b. take 50-70% by weight of Coix Seed 20, pulverize it, pass through a No. 6 sieve, and fine powder it for later use;

[0129] c. Crush Pinellia 12, Alisma 9, Puhuang 8, Rhubarb 8, Clematis 8, and the remaining coix seed into a coarse powder, and use the weight of the residue after supercritical extraction of volatile oil from Zezhu, fried Atractylodes...

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Abstract

The invention provides fat-burning dredging particles and a preparation method thereof. The fat-burning dredging particles are prepared by the following raw materials through the following steps: a smashing curcuma zedoary, roasted rhizoma atractylodis macrocephalae and pericarpium citri reticulatae, screening mixed powder through a third-level screen, supercritically extracting volatile oil of the mixed powder through carbon dioxide (CO2), performing beta-CD inclusion on the volatile oil through a saturated water solution method, refrigerating for 12-30 hours, leaching to obtain beta-cyclodextrin inclusion complex of the volatile oil, and keeping the beta-cyclodextrin inclusion complex of the volatile oil for use; b smashing 50-70% of coix seeds by weight, screening powder of the coix seeds through a sixth-level screen and keeping fine powder for use; c smashing pinellia ternate, rhizoma alismatis, typha angustifolia, Chinese rhubarb, radix clematidis and the rest of the coix seeds into coarse powder, performing alcohol extraction on the coarse powder and the residue remained after the volatile oil is supercritically extracted out of the curcuma zedoary, the roasted rhizoma atractylodis macrocephalae and the pericarpium citri reticulatae for twice, combining alcohol extract, condensing and drying to obtain extractum; and d smashing dried extractum, mixing the smashed extractum with the coix seed fine powder obtained in the b step, screening the mixture through a sixth-level screen, adding the beta-CD inclusion complex obtained in the a step and steviosin into the screenedmixture, evenly mixing the mixture, conventionally palletizing the mixture, and split charging to obtain the fat-burning dredging particles.

Description

technical field [0001] The invention relates to medicines and a preparation method thereof, in particular to a preparation method of Xiaozhi Tongmai Granules. Background technique [0002] At present, with the improvement of people's living standards and changes in lifestyle and diet structure, the number of patients with hyperlipidemia is gradually increasing, and the age of onset of cardiovascular and cerebrovascular diseases is gradually becoming younger. In clinical work, young and middle-aged patients with hyperlipidemia can often be found, accompanied by obesity, hypertension, diabetes, fatty liver, coronary heart disease, stroke and other diseases, which seriously threaten their health. This is related to the fast-paced life of the young and middle-aged population, greater mental stress, often ignoring a reasonable dietary structure, excessive drinking and smoking, and less physical activity. In addition to reducing pathogenic factors such as rationally adjusting die...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/16A61P3/06
Inventor 姚莉马秋菊孙萍王华孙立明
Owner THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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