Method for synthesizing tebuthiuron technical material

Abstract

The invention discloses a method for synthesizing a tebuthiuron technical material. The method comprises the following steps: taking 5-tert-butyl-2-methylamino-1,3,4-thiadiazole as a starting material; carrying out salt forming reaction and photochemical reaction in an organic solvent to prepare N-methyl-N-(5-tert-butyl-1,3,4-thiadiazole) carbamyl chloride; and introducing monomethylamine gas into the N-methyl-N-(5-tert-butyl-1,3,4-thiadiazole) carbamyl chloride to generate the tebuthiuron. The method has the advantages of simplicity in process, low production cost, high product purity, high yield, high production safety and the like.

Description

technical field

[0001] The invention relates to a method for synthesizing the original drug of tebuthiauron. Background technique

[0002] Tebuthiuron, common name tebuthiuron, chemical name is 1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea. It is a broad-spectrum herbicide for the control of herbs and grasses, mainly used to control weeds in non-arable land, shrubs in pasture areas, grasses and broad-leaved weeds in sugarcane fields.

[0003] According to literature reports at home and abroad, there are three main methods for synthesizing terbuthiauron at present. (1) As disclosed in U.S. Patent us4283543, 5-tert-butyl-2-methylamino-1,3,4-thiadiazole is used as a starting material, and toluene is used as a solvent, and methyl isocyanate is added dropwise to react to obtain special Buthiuron original drug. The method uses methyl isocyanate, which is inflammable and explosive, has great toxicity, low boiling point, and extremely unsafe production. (2) As disclose...

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