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Application of indole diketopiperazine derivatives

A technology of indole diketopiperazine and its derivatives, which is applied in the field of insecticides derived from microorganisms, can solve the problems of human and animal poisoning, environmental pollution, mutagenesis, etc., achieve good Artemia lethal activity, simple production process, small effect

Active Publication Date: 2012-09-19
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the extensive use of chemical pesticides, the resistance of plant diseases and insect pests to them has become more and more obvious, which has also brought problems such as environmental pollution, human and animal poisoning, and three causes (carcinogenic, teratogenic, and mutagenic)

Method used

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  • Application of indole diketopiperazine derivatives
  • Application of indole diketopiperazine derivatives
  • Application of indole diketopiperazine derivatives

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Effect test

Embodiment 1

[0016] Indole diketopiperazine derivatives are the indole diketopiperazine derivatives shown in formula (one) or formula (two), and the compounds of its formula (one) and formula (two) are tetradehydroechinulin and didehydroechinulin respectively, All are known compounds of indole diketopiperazines.

[0017]

[0018] Formula (1) Formula (2)

[0019] Among them, the preparation process of known indole diketopiperazine compounds tetradehydroechinulin (Formula 1) and didehydroechinulin (Formula 2) can refer to the literature Helv.Chim.Acta, 2012, 95, 163-168 and Helv.Chim.Acta, respectively. The description in 2010, 93, 1758-1763 was carried out.

Embodiment 2

[0020] Embodiment 2: insecticidal activity test

[0021] Artemia (brine shrimp), also known as saltwater Artemia, belongs to the phylum Arthropoda, Crustacea, Order Anocaria, Saltwater Artemia family, and the genus Artemia. As a model for insecticide screening, Artemia has been reported at home and abroad. Wang Zaiqiang et al. [Pesticides, 2011, 50(4): 261-263] used Artemia as a model organism to evaluate the killing effect of 14 common insecticides. Insecticidal activity, the results show that the method of screening compounds with insecticidal activity with Artemia is simple, and it is sensitive to a variety of insecticides with different mechanisms of action; Hu Zhiyu et al. Artemia is used as an indicator organism to quickly screen compounds with insecticidal activity in marine actinomycetes; Blizzard T.A. et al. Analogues of the element. In conclusion, as a model organism for the determination of insecticidal activity, Artemia has the advantages of wide sources, simple ...

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Abstract

The invention relates to microbial source pesticide, in particular to an application of indole diketopiperazine derivatives. The indole diketopiperazine derivatives can be used for preparing agricultural insecticide and are shown as a formula (1) or a formula (2). The indole diketopiperazine derivatives related by the invention are used as microbial source natural products, only contain four kinds of elements including carbon, hydrogen, oxygen and nitrogen, can be easily degraded in environment and have small influence on non-target organisms, particularly on natural enemy of pests and beneficial microorganisms. The formula (1) and the formula (2) are shown in the accompanying drawing.

Description

technical field [0001] The present invention relates to microbial source insecticide, specifically the application of a kind of indole diketopiperazine derivatives. Background technique [0002] According to the World Food and Agriculture Organization (FAO) estimate, in the world, about 20% of the food loss caused by pests and diseases, about 30% of the cotton loss, and about 20% of the loss of fruit trees and vegetables in the world. Therefore, how to prevent and treat plant diseases more effectively has become a top priority. Among the many methods of prevention and control, chemical pesticide control plays an extremely important role. However, with the extensive use of chemical pesticides, the resistance of plant diseases and insect pests to them has become more and more obvious, which has also brought about problems such as environmental pollution, human and animal poisoning, and three causes (carcinogenic, teratogenic, and mutagenic). Compared with traditional chemica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/60A01P7/00
Inventor 王斌贵杜丰玉
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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