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Application of 15-norcadina-2-en-5,9-diol

A naphthalene ring-type and sesquiterpene technology, which is applied in the field of botanical fungicides and insecticides, can solve the problems of human and animal poisoning, environmental pollution and the like, and achieves the effects of good environmental compatibility and difficult drug resistance.

Active Publication Date: 2017-09-22
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the prevention and control of apple diseases and insect pests mainly relies on the long-term and large-scale use of various chemically synthesized pesticides. Although it can achieve a good control effect, as the public pays more and more attention to food safety and environmental protection, its disadvantages are becoming increasingly prominent.
On the one hand, the resistance of plant diseases and insect pests to it is becoming more and more obvious; on the other hand, it has also brought problems such as environmental pollution and human and animal poisoning.
There are no further reports on the biological activity of this compound

Method used

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  • Application of 15-norcadina-2-en-5,9-diol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 15-norcadina-2-en-5,9-diol represented by formula (1) is a known compound of naphthalene ring type sesquiterpenes.

[0016] The preparation process of 15-norcadina-2-en-5,9-diol shown in formula (1) can be found in literatures Wang Qing-hu, Ao Wu-li-ji, Wu Xiao-lan, Tai Wen-quan, Dai Nayintai. Sesquiterpenes fromStems of Syringapinnatifolia var. alashanensis . Chinese Herbal Medicines, 2013, 5(4): 317–319.

Embodiment 2

[0017] Example 2: Antibacterial activity test

[0018] The microdilution method was used to determine the antibacterial activity of the compound represented by formula (1) against apple rot bacteria, apple rot and apple anthracnose ("From Natural Products to New Pesticide Creation - Principles and Methods", Wu Wenjun, 2006, Chemical Industry publishing house).

[0019] 1) Preparation of bacterial suspension

[0020] After inoculating the test fungi on the surface of PDA medium and incubating at 28 °C for 72 h, aspirate 2 mL of sterile 0.85% NaCl solution (containing 0.25% Tween-20) to wash the culture, and gently scrape the colonies with a glass spatula. Pipette an appropriate amount of bacterial suspension into a sterile test tube, adjust to 0.5 McFarland turbidity (equivalent to 1.5 × 10 8 CFU / mL) spare;

[0021] 2) Preparation of samples

[0022] Take 1 mg of the sample to be tested (the compound represented by formula (1)), dissolve it in 100 μL of 50% DMSO, mix well,...

Embodiment 3

[0029] Example 3: Wettable powder

[0030] Formulation (weight ratio): 15-norcadina-2-en-5,9-diol powder 20%, silica 20%, sodium lauryl sulfate 5%, CMC 1.0% and pull powder 3.0%, attapulgite soil balance.

[0031] Preparation method: Mix the above-mentioned raw materials evenly, control the processing temperature to 0-50 ℃, in a jet mill or other high-mesh pulverizer, pulverize to more than 150 mesh, control the moisture at 6-8% (mass percentage), pH Control at 7-7.5.

[0032] How to use: Spray 200 times liquid on apple stems and leaves.

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Abstract

The invention discloses application of 15-norcadina-2-en-5,9-diol. The 15-norcadina-2-en-5,9-diol shown as structural formula (I) has good inhibiting activity for main diseases of apples such as Valsa mali Miyabe et Yamada, Botryosphaeria dothidea and Glomerella cingulate, with minimum inhibiting concentrations of 0.064 mg / mL, 0.064 mg / mL and 0.128 mg / mL respectively. Additionally, the 15-norcadina-2-en-5,9-diol with high insecticidal activity can serve as a novel pesticide component or a lead compound with bactericidal or insecticidal effect. The 15-norcadina-2-en-5,9-diol as a plant-derived natural product has the advantages of low pesticide residues, environmental compatibility and no harm to humans and livestock as compared with chemical synthesized pesticides.

Description

technical field [0001] The invention relates to botanical fungicides and insecticides, in particular to the application of a naphthalene ring type sesquiterpene compound 15-norcadina-2-en-5,9-diol. Background technique [0002] As one of the important economic crops in my country, the cultivation area of ​​apples reached 2.22 million hm2 in 2012, and the annual output reached 33.7 million tons. In the high-yield and high-quality cultivation of apples, plant diseases have become an important factor restricting the development of the apple industry. At present, apple rot is still the first major disease on apple trees, and it is prevalent to varying degrees every year. Apple ring disease and apple anthracnose are also increasing year by year. In some orchards of apple producing areas around the Bohai Bay The harm has even surpassed the rot disease. In addition, the impact of apple pests on apple yield and quality is also increasing. [0003] At present, the prevention and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/06A01P3/00A01P7/00
CPCA01N31/06
Inventor 杜丰玉肖琳周远明张相飞
Owner QINGDAO AGRI UNIV
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