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Shilintong puffed granules and preparation method of same

A technology of puffed granules and stone spray, applied in the field of medicine, can solve the problems of poor shape, unfavorable preservation, packaging and preservation, and poor fluidity.

Inactive Publication Date: 2014-08-06
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules prepared according to the existing methods usually need to add a large amount of auxiliary materials to form the shape, and the shape of the granules is usually indeterminate, the particles are scattered, broken, poor in shape, poor in fluidity, and easy to absorb moisture, which is not conducive to storage, packaging and storage.

Method used

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  • Shilintong puffed granules and preparation method of same
  • Shilintong puffed granules and preparation method of same
  • Shilintong puffed granules and preparation method of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Take the dry extract, crush it, add an appropriate amount of sucrose, and make granules with a bulk density of about 0.78g / cm 3 , first dry the granules at a low temperature of 50-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules are puffed; then maintain high temperature conditions and dry the granules to Below 2%, dry to obtain 200g of granules, pack into 100 bags, and get ready.

Embodiment 2

[0070] Take the dry extract, crush it, add appropriate amount of dextrin and sweetener to make granules, the bulk density is about 0.81g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 75-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granule moisture to Below 2%, dry to obtain 200g of granules, pack into 100 bags, and get ready. [The granules are sugar-free]

Embodiment 3

[0072] Take the dry extract, crush it, add an appropriate amount of dextrin, and make granules with a bulk density of about 0.83g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granules to Below 2%, dry to obtain 200g of granules, pack into 100 bags, and get ready. [The granules are sugar-free]

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Abstract

The invention belongs to the medicine field, specifically to Shilintong puffed granules and a preparation method of the same. A technical problem to be solved in the invention is to provide spheroidic Shilintong puffed granules with a smooth and compact shape and good fluidity. Extraction or decoction of snowbell-leaf tickclover can be performed with reference to the prior art. A main difference between the preparation method and the prior art is to make granules into a state of compression. In a granule drying stage, the moisture content is firstly controlled in the range of from 4% to 5% by low temperature control, then the granules are heated and puffed under a high temperature condition, the obtained product is dried and granulated. The preparation method of the invention can form spherical or spheroidic granules with the smooth and compact shape. Cavitation and puffing phenomenon can be seen inside the granules. The granules are not easy to break into pieces and are in a good shape; the angle of repose of the granules is in the range of from 10 DEG to 25 DEG, the granules are of good fluidity and are not easy to absorb moisture. The dosage of auxiliary materials is low. A cream-shaped material is not easy to appear when the granules are mixed with water, and the granules are easy to be mixed with water. The Shilintong puffed granules of the invention can also be used as raw materials to prepare tablets or capsules by tabletting or capsulation according to the conventional art.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to Shilintong expanded granules and a preparation method thereof. Background technique [0002] At present, in order to facilitate the application of traditional Chinese medicine, the common dosage forms of compound Chinese medicine are granules, tablets, capsules, etc., and there are also single Chinese medicines extracted and made into formula granules. Shilintong granule clears dampness and heat, promotes diuresis and expels stones. It is used for urinary calculus, pyelonephritis, and cholecystitis caused by damp-heat in the lower energizer. [0003] Shilintong granules are usually obtained by decocting raw materials with water or extracting them with organic solvents such as ethanol to obtain extracts, and then adding auxiliary materials to make soft materials, then granulating and sizing the granules to obtain granules. However, the granules prepared according to the exist...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/48A61K36/53A61J3/00A61P13/00
Inventor 高庆凌
Owner SICHUAN XUYANG PHARMA