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Xinshenghuapuffed granules and preparation method thereof

A kind of puffed granule, biochemical technology, applied in the field of medicine, can solve the problems of scattered granules, poor shape, poor fluidity and so on

Active Publication Date: 2012-10-17
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules prepared according to the existing methods usually need to add a large amount of auxiliary materials to form the shape, and the shape of the granules is usually indeterminate, the particles are scattered, broken, poor in shape, poor in fluidity, and easy to absorb moisture, which is not conducive to storage, packaging and storage.

Method used

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  • Xinshenghuapuffed granules and preparation method thereof
  • Xinshenghuapuffed granules and preparation method thereof
  • Xinshenghuapuffed granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Take the dry extract, crush it, add an appropriate amount of brown sugar, and make granules with a bulk density of about 0.82g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%; then maintain at a low temperature of 65-95°C for at least 5 minutes until the granules are puffed; then maintain a high temperature condition and dry the granule moisture to Below 2%, spray into volatile oil, obtain granule 330g, divide into 165 bags and get final product.

Embodiment 2

[0069] Take the dry extract, crush it, add appropriate amount of dextrin and sweetener to make granules, the bulk density is about 0.84g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 75-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granule moisture to Below 2%, spray into volatile oil to obtain 350g of granules, which are divided into 175 bags. [The granules are sugar-free]

Embodiment 3

[0071] Take the dry extract, crush it, add an appropriate amount of dextrin, and make granules with a bulk density of about 0.83g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granules to Below 2%, spray into volatile oil, obtain granule 330g, pack into 165 bags, to get final product. [The granules are sugar-free]

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Abstract

The invention belongs to the medical field, and especially to Xinshenghua puffed granules and a preparation method thereof. The technology problem that the invention solves is to provide the Xinshenghua puffed granules with smooth and compact texture and good fluidity, and the shapes of granules are ball-like. Extraction and decoction of the Xinshenghua puffed granules can be performed according to existing methods during the granulation. A main difference is to prepare the granules of the Xinshenghua puffed granules into a compressed state. During a process of drying, water content in the particles is controlled at 4-5% at a low temperature, the particles are heated at a high temperature to become puffed and the granules are obtained after drying. The preparation method provided by the invention enables the spherical or granules to have smooth and compact texture. The interior of a particle has a phenomenon of cavity puffing. The particles have the following advantages: no easy disintegration, attractive appearance, particle angle of repose of 10-25DEG, high fluidity, no easy moisture absorption, fewer supplementary materials, required, no easy pasty object generation and easy operation when used in brewing. The water-soluble Xinshenghua puffed granules provided by the invention can be used as raw materials for preparing tablets and capsules, and the processes of tabletting and capsulation can performed according to regular processes.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new biochemical puffed granule and a preparation method thereof. Background technique [0002] At present, in order to facilitate the application of traditional Chinese medicine, the common dosage forms of compound Chinese medicine are granules, tablets, capsules, etc., and there are also single Chinese medicines extracted and made into formula granules. The main ingredients of Xinhua Granules are angelica, chuanxiong, peach kernel, licorice (burnt), dried ginger (charcoal), motherwort, safflower, which can promote blood circulation, remove blood stasis, and relieve pain. It can't be used for postpartum lochia and abdominal pain, and it can also be used for vaginal bleeding and menorrhagia caused by IUD. [0003] Xinhua granules are usually obtained by decocting raw materials with water or extracting them with organic solvents such as ethanol to obtain extracts, and then ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/16A61J3/00A61P15/00
Inventor 高庆凌
Owner SICHUAN XUYANG PHARMA