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Anti-cold detoxification puffed granule and preparation method thereof

A technology of puffing granules and granules, applied in the field of medicine, can solve problems such as poor shape, poor fluidity, and scattered granules

Inactive Publication Date: 2014-05-28
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules prepared according to the existing methods usually need to add a large amount of auxiliary materials to form the shape, and the shape of the granules is usually indeterminate, the particles are scattered, broken, poor in shape, poor in fluidity, and easy to absorb moisture, which is not conducive to storage, packaging and storage.

Method used

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  • Anti-cold detoxification puffed granule and preparation method thereof
  • Anti-cold detoxification puffed granule and preparation method thereof
  • Anti-cold detoxification puffed granule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0067] Take the dry extract, crush it, add an appropriate amount of sucrose, and make granules with a bulk density of about 0.85g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%; then maintain at a low temperature of 65-95°C for at least 5 minutes until the granules are puffed; then maintain a high temperature condition and dry the granule moisture to Below 2%, spray into volatile oil to obtain 200g of granules, which can be divided into 100 bags.

Embodiment 2

[0069] Take the dry extract, crush it, add appropriate amount of dextrin and sweetener to make granules, the bulk density is about 0.84g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 75-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granule moisture to Below 2%, spray into volatile oil to obtain 200g of granules, which are divided into 100 bags. [The granules are sugar-free]

Embodiment 3

[0071] Take the dry extract, crush it, add an appropriate amount of dextrin, and make granules with a bulk density of about 0.83g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granules to Below 2%, spray into volatile oil to obtain 200g of granules, which are divided into 100 bags. [The granules are sugar-free]

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Abstract

The invention relates to an anti-cold detoxification puffed granule and a preparation method thereof, belonging to the medicine field. The invention provides a spheroidic anti-cold detoxification puffed granule with a smooth and compact profile and a good fluidity. An extraction or decoction technology and a pelletizing technology of the particulate agent of the invention are carried out according to present methods; and the preparation method is characterized in that particles are prepared in a compression state, a particle drying process comprises the steps of carrying out low temperature drying until the water content is 4-5% and then heating the particles at a high temperature to puff the particles, and the particulate agent is prepared after drying. According to the preparation method provided by the invention, the spherical or spheroidic particles with the smooth and compact profile are formed, a vacuolated puffing phenomenon exists in the particles, the particles are not shattered, and the profile of the particles is good; the range of the angle of repose of the particles is 10-25DEG, the fluidity is good, and moisture absorbing is difficult; the application amount of auxiliary materials is less; and a paste difficultly appears at the bottom of a cup during brewing, so the particles is easy to brew. The anti-cold detoxification puffed granule provided by the invention, which can be used as a raw material for preparing tablets or capsules, can be compressed to form the tablets or filled into the capsules according to routine technologies.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to anti-sensitivity and detoxification puffed granules and a preparation method thereof. Background technique [0002] At present, in order to facilitate the application of traditional Chinese medicine, the common dosage forms of compound Chinese medicine are granules, tablets, capsules, etc., and there are also single Chinese medicines extracted and made into formula granules. The main ingredients of Kanggan Jiedu Granules are kudzu root, honeysuckle, scutellaria baicalensis, forsythia, Folium Isatidis, Guanzhong, Radix Isatidis, chrysanthemum, Angelica dahurica, capillary, and gardenia. It can clear away heat and detoxify, and is suitable for wind-heat and cold. [0003] Kangganjiedu granules are usually obtained by decocting raw materials with water or extracting them with organic solvents such as ethanol to obtain extracts, and then adding auxiliary materials to make soft mat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/85A61K36/744A61K9/16A61J3/00A61P31/00
Inventor 高庆凌
Owner SICHUAN XUYANG PHARMA