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Aporosa dioica puffed granules and preparation method thereof

A technology of puffed granules and Yinchai, which is applied in the field of medicine and can solve the problems of poor shape, loose granules, unfavorable storage, packaging and storage, etc.

Inactive Publication Date: 2014-06-18
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules prepared according to the existing methods usually need to add a large amount of auxiliary materials to form the shape, and the shape of the granules is usually indeterminate, the particles are scattered, broken, poor in shape, poor in fluidity, and easy to absorb moisture, which is not conducive to storage, packaging and storage.

Method used

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  • Aporosa dioica puffed granules and preparation method thereof
  • Aporosa dioica puffed granules and preparation method thereof
  • Aporosa dioica puffed granules and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0067] Take the dry extract, crush it, add an appropriate amount of sucrose, and make granules with a bulk density of about 0.86g / cm 3 , first dry the granules at a low temperature of 50-60°C to a water content of 4-5%; then maintain at a low temperature of 65-95°C for at least 5 minutes until the granules are puffed; then maintain a high temperature condition and dry the granule moisture to 2% or less, add peppermint oil, mix well to get 135g of granules, and divide into 54 bags.

Embodiment 2

[0069] Take the dry extract, crush it, add appropriate amount of dextrin and sweetener to make granules, the bulk density is about 0.88g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 75-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition and dry the granule moisture to Below 2%, add peppermint oil to obtain 100g of granules, which are divided into 100 bags. [The granules are sugar-free]

Embodiment 3

[0071] Take the dry extract, crush it, add an appropriate amount of dextrin, and make granules with a bulk density of about 0.83g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition and dry the granule moisture to Below 2%, add peppermint oil to obtain 100g of granules, which are divided into 100 bags. [The granules are sugar-free]

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Abstract

The invention belongs to the medicine field and particularly relates to aporosa dioica puffed granules and a preparation method thereof. The technology problem solved by the invention is to provide ball-like aporosa dioica puffed granules with smooth and compact apperances and good fluidity. The extraction or decocting technology can be performed according to the present method during the granulating process. The main difference between the method in the invention and the present method is making the granules into a state of compression. In the process of drying the granules, the moisture in the granules is controlled at 4-5 percent, then the granules are heated at high temperature to become puffed and the finished products of the granules are obtained by drying the puffed granules. The preparation method of the invention can form ball-shaped or ball-like granules with smooth surfaces and compact texture. The interiors of the particles have a phenomenon of cavitation expansion which enables the granules to have good shape and non-easily-broken property. An angle of repose of granules is between 10 DEG to 25 DEG. The granules prepared by the method have characteristics that the granules have good fluidity, do not easily absorb moisture and require less auxiliary material. Besides, the paste material is hard to appear when the granules are mixed with water, so that the mixing is very easy. The aporosa dioica granules of the invention can be used as a raw material for preparing tablets and capsules according to the ordinary technologies of compressing tablets and stuffing capsules.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of Yinchai expanded granules. Background technique [0002] At present, in order to facilitate the application of traditional Chinese medicine, the common dosage forms of compound Chinese medicine are granules, tablets, capsules, etc., and there are also single Chinese medicines extracted and made into formula granules. Yinchai Granule clears away heat, relieves exterior syndrome, and relieves cough. For wind-heat cold, fever and cough. [0003] Yinchai granules are usually prepared by decocting raw materials with water or extracting them with organic solvents such as ethanol to obtain extracts, and then adding auxiliary materials to make soft materials, then granulating and sizing to obtain granules. However, the granules prepared according to the existing method usually need to add a large amount of auxiliary materials to form the granules, and the sha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K9/16A61J3/00A61P11/14A61P29/00
Inventor 高庆凌
Owner SICHUAN XUYANG PHARMA