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Puffed Spica Prunellae, mulberry leaf and chrysanthemum granule, and preparation method thereof

A technology of puffed granules and mulberry chrysanthemum, applied in the field of medicine, can solve the problems of poor appearance, unfavorable preservation, packaging and preservation, and easy moisture absorption.

Inactive Publication Date: 2014-05-28
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules prepared according to the existing methods usually need to add a large amount of auxiliary materials to form the shape, and the shape of the granules is usually indeterminate, the particles are scattered, broken, poor in shape, poor in fluidity, and easy to absorb moisture, which is not conducive to storage, packaging and storage.

Method used

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  • Puffed Spica Prunellae, mulberry leaf and chrysanthemum granule, and preparation method thereof
  • Puffed Spica Prunellae, mulberry leaf and chrysanthemum granule, and preparation method thereof
  • Puffed Spica Prunellae, mulberry leaf and chrysanthemum granule, and preparation method thereof

Examples

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Effect test

Embodiment 1

[0067] Take the dry extract, crush it, add an appropriate amount of sucrose powder, mix well, and make granules with a bulk density of about 0.81g / cm 3 , first dry the granules at a low temperature of 50-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules are puffed; then maintain high temperature conditions and dry the granules to 2% or less, dried to obtain 150g of granules, divided into 100 bags, that is.

Embodiment 2

[0069] Take the dry extract, crush it, add appropriate amount of dextrin and sweetener to make granules, the bulk density is about 0.80g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 75-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granule moisture to 2% or less, dry to obtain 100g of granules, and pack into 100 bags. [The granules are sugar-free]

Embodiment 3

[0071] Take the dry extract, crush it, add an appropriate amount of dextrin, and make granules with a bulk density of about 0.83g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granules to 2% or less, dry to obtain 100g of granules, and pack into 100 bags. [The granules are sugar-free]

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Abstract

The invention which belongs to the medicine field concretely relates to a puffed Spica Prunellae, mulberry leaf and chrysanthemum granule, and a preparation method thereof. A technical problem be solved in the invention is to provide a spheroidic puffed Spica Prunellae, mulberry leaf and chrysanthemum granule with a smooth and compact profile and a good fluidity. According to an extraction or decoction technology of the granule of the invention, pelletizing can be carried out according to present methods; and main differences comprise that granules are prepared in a compression state, a granule drying process comprises the steps of carrying out low temperature control until the water content is 4-5% and then heating the granules at a high temperature to puff the granules, and the granule is prepared after drying. According to the preparation method of the invention, the spherical or spheroidic granules with the smooth and compact profile are formed, a void puffing phenomenon exists in the granules, the granule are not shattered, and the profile of the granules is good; the range of the angle of repose of the granules is 10-25DEG, the fluidity is good, and moisture absorbing is difficult; the application amount of auxiliary materials is less; and a paste difficultly appears at the bottom of a cup during brewing, so the granule is easy to brew.. The puffed Spica Prunellae, mulberry leaf and chrysanthemum granule of the invention, which can be used as a raw material for preparing tablets or capsules, can be compressed to form the tablets or filled into the capsules according to routine technologies

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to Xiasangju puffed granules and a preparation method thereof. Background technique [0002] At present, in order to facilitate the application of traditional Chinese medicine, the common dosage forms of compound Chinese medicine are granules, tablets, capsules, etc., and there are also single Chinese medicines extracted and made into formula granules. Xia Sangju Granule clears the liver and improves eyesight, dispels wind and dissipates heat, removes dampness and arthralgia, and relieves sores. It is used for wind-heat cold, conjunctival congestion, headache, high blood pressure, dizziness and tinnitus, sore throat, boils and swelling, and can be used as a refreshing drink. . [0003] Xiasangju granules are usually obtained by decocting raw materials with water or extracting them with organic solvents such as ethanol to obtain extracts, and then adding auxiliary materials to m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61K9/16A61J3/00A61P9/12A61P11/04A61P17/02A61P25/04
Inventor 高庆凌
Owner SICHUAN XUYANG PHARMA