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Water-soluble isatis root puffed granules and preparation method thereof

A technology of puffed granules and Radix isatidis, applied in the field of medicine, can solve the problems of poor shape, poor fluidity, scattered granules, etc.

Inactive Publication Date: 2014-08-13
SICHUAN XUYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules prepared according to the existing methods usually need to add a large amount of auxiliary materials to form the shape, and the shape of the granules is usually indeterminate, the particles are scattered, broken, poor in shape, poor in fluidity, and easy to absorb moisture, which is not conducive to storage, packaging and storage.

Method used

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  • Water-soluble isatis root puffed granules and preparation method thereof
  • Water-soluble isatis root puffed granules and preparation method thereof
  • Water-soluble isatis root puffed granules and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0066] Take the dry extract, crush it, mix appropriate amount of sucrose, and make granules with a bulk density of about 0.84g / cm 3 , first dry the granules at a low temperature of 40-60°C to a moisture content of 4-5%, and then maintain at a high temperature of 65-75°C for at least 5 minutes until the granules expand; then maintain the high temperature condition and dry the granules to Below 2%, dried to obtain 400g of granules, divided into 200 bags, to get final product.

Embodiment 2

[0068] Take the dry extract, crush it, add appropriate amount of dextrin and sweetener, and make granules with a bulk density of about 0.86g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 75-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granule moisture to Below 2%, dried to obtain 400g of granules, divided into 200 bags, to get final product. [The granules are sugar-free]

Embodiment 3

[0070] Take the dry extract, crush it, add an appropriate amount of dextrin, and make granules with a bulk density of about 0.85g / cm 3 , first dry the granules at a low temperature of 40-60°C to a water content of 4-5%, and then maintain at a high temperature of 65-95°C for at least 5 minutes until the granules expand; then maintain the high temperature condition, dry the granules to Below 2%, dried to obtain 400g of granules, divided into 200 bags, to get final product. [The granules are sugar-free]

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Abstract

The invention belongs to the medical field, and especially to water-soluble isatis root puffed granules and a preparation method thereof. The technology problem that the invention solves is to provide water-soluble puffed granules for treating urolithiasis with smooth and compact texture and good fluidity, and the shapes of granules are ball-like. Extraction and decoction processes of the water-soluble isatis root puffed granules can be performed according to existing methods during the granulation. A main difference is to prepare the granules of the water-soluble isatis root puffed granules into a compressed granules with a bulk density being over 0.78g / cm3. During a process of drying, water content in the particles is controlled at 4-5% at a low temperature, the granules are heated at a high temperature to become puffed and the granules are obtained after drying. The preparation method provided by the invention enables the spherical particles to have smooth appearance and compact texture. The interior of granules has a phenomenon of cavity puffing. The particles have the following advantages: no easy disintegration, attractive appearance, particle angle of repose of 10-25DEG, high fluidity, no easy moisture absorption, fewer supplementary materials required, no easy pasty object generation and easy operation when used in brewing infusion. The water-soluble isatis root puffed granules provided by the invention can be used as raw materials for preparing tablets and capsules, and the processes of tablet compressing and capsule filling can be performed according to regular processes.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a water-soluble isatidis puffed granule and a preparation method thereof. Background technique [0002] At present, in order to facilitate the application of traditional Chinese medicine, the common dosage forms of compound Chinese medicine are granules, tablets, capsules, etc., and there are also single Chinese medicines extracted and made into formula granules. Banlangen granule clears heat and detoxifies, cools blood and relieves throat. It is used for sore throat and dry mouth and throat caused by excessive heat in the lung and stomach; acute tonsillitis sees the above syndromes. [0003] Radix isatidis granules are usually obtained by decocting Radix isatidis with water or extracting with organic solvents such as ethanol to obtain extracts, and then adding auxiliary materials to make soft materials, granulating and sizing to obtain granules. However, the granules prepar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/00A61K36/195A61K36/315A61K9/16
Inventor 高庆凌
Owner SICHUAN XUYANG PHARMA