Application of oroxylin A in preparing medicament for treating pneumonia

A technology of melaleuca, pneumonia, applied in the field of medicine, can solve problems such as treatment failure

Inactive Publication Date: 2012-10-31
JILIN UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Current drugs for the treatment of Staphylococcus aureus pneumonia usually use oxacillin and cloxacillin, but due to the emergence of MRSA, treatment failure often occurs

Method used

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  • Application of oroxylin A in preparing medicament for treating pneumonia
  • Application of oroxylin A in preparing medicament for treating pneumonia

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0007] 1. Hemolysis test

[0008] The purified α-hemolysin was serially diluted twice in a 96-well plate, and 10 7 Rabbit red blood cells were incubated at 37°C for 30 min and then centrifuged. The highest dilution factor that lysed red blood cells was regarded as the hemolysis titre.

[0009] The hemolytic titers of α-hemolysin without adding melaleulin A and adding different concentrations of melaleulin A are shown in Table 1:

[0010] Table 1. Inhibitory effect of melaleurin A on the hemolytic activity of α-hemolysin

[0011] Melaleucain A (μg / ml)

Hemolysis titre

0

2048

8

32

4

128

2

256

1

1024

[0012] 2. Protection test of human lung epithelial cells (A549) injury

[0013] Staphylococcus aureus NCTC8325-4 cultured in TSB medium to OD 600nm =0.5, take 5ml of bacterial culture, centrifuge and resuspend in 10ml of F12K medium. A549 cells were cultured in F12K medium (adding 10% fetal bovine ...

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Abstract

The invention relates to an application of oroxylin A in preparing a medicament for treating pneumonia. The oroxylin A with a function of treating staphylococcus aureus infection is proved by a rabbit erythrocyte hemolysis test, a human pulmonary epithelial cell (A549) damage protection test and a mice staphylococcal aureus pneumonia model. Compared with antibiotics for treating, the oroxylin A for treating has the characteristics of having no drug resistance and being high in curative ratio.

Description

technical field [0001] The invention relates to the application of kelplin A in the preparation of medicines for treating pneumonia, which belongs to the field of medicine. 1. Background technology [0002] Oroxylin A is a flavonoid compound extracted from the seeds of the wood butterfly. Both coccus and meningococcus have inhibitory effect, and the minimum inhibitory concentration (MIC) is between 64-128μg / ml. But so far there is no report on the use of melaleucain A in the treatment of bacterial pneumonia at home and abroad. [0003] Bacterial pneumonia is a disease caused by infections such as Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, Legionella, etc. The mortality rate of this disease is extremely high in children, the elderly and immunocompromised patients. In recent years, the extensive use of antibiotics has led to an increase in the rate of bacterial resistance, making the treatment of bacterial pneumonia face ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P11/00A61P31/04
Inventor 邓旭明董靖邱家章牛效迪
Owner JILIN UNIV
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