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Combination of multiple genetic single nucleotide polymorphisms and environmental factors related to coronary heart disease and application of combination

A single nucleotide polymorphism and polymorphic site technology, applied in the direction of bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, microbial measurement/inspection, etc., can solve the lack of identification methods , the exact genetic molecular mechanism is poorly understood, etc.

Active Publication Date: 2012-10-31
FUWAI HOSPITAL OF CARDIOVASCULAR DESEASE CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

From basic to clinical, people have done a lot of research on this, and accumulated a lot of knowledge on the risk factors of coronary heart disease and the pathophysiology of coronary heart disease, but the exact genetic molecular mechanism of coronary heart disease and myocardial infarction is not known Very few, there has been a lack of comprehensive, systematic and effective identification methods for how to identify genetic susceptibility genes and the genetic susceptibility of subjects to coronary heart disease

Method used

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  • Combination of multiple genetic single nucleotide polymorphisms and environmental factors related to coronary heart disease and application of combination
  • Combination of multiple genetic single nucleotide polymorphisms and environmental factors related to coronary heart disease and application of combination
  • Combination of multiple genetic single nucleotide polymorphisms and environmental factors related to coronary heart disease and application of combination

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Effect test

Embodiment 1

[0047] First, 7,012 patients with coronary heart disease and 8,579 normal subjects were selected from the Han population in China. Fasting blood was collected and relevant information such as age, gender, blood pressure level, blood lipid level, height, weight, smoking, drinking, and disease history were collected. as follows:

[0048] Inclusion criteria for case-control samples: coronary heart disease cases include patients with myocardial infarction and angina pectoris. The diagnostic criteria for the inclusion of myocardial infarction cases are the diagnostic criteria for acute myocardial infarction (according to the diagnostic criteria of WHO in 1979): that is, typical chest pain symptoms lasting for more than 30 minutes; ST-segment elevation in two consecutive leads of electrocardiogram (limb leads 0.1mv, chest lead 0.2mv) with a series of dynamic changes; the concentration of serum markers of myocardial necrosis increased, such as the increase of troponin (TNT / TNI), the ...

Embodiment 2

[0084] For example, Zhang San came to inquire about his risk of coronary heart disease. The analysis will be performed as follows:

[0085] (1) Conduct questionnaires and anthropometric measurements

[0086] Collect Zhang San's age, gender, smoking and drinking; measure height and weight, and calculate body mass index. Get the following information: Zhang San, male, 55 years old, non-smoking, drinking, height 172cm, weight 75KG. The calculated body mass index was 25.35.

[0087] (2) Extract fasting venous blood (anticoagulant, non-anticoagulant), and measure blood glucose and high-density lipoprotein cholesterol in serum

[0088] Zhang San's blood sugar level is 90mg / dl, and his high-density lipoprotein cholesterol is 45mg / dl.

[0089] (3) Separation of DNA in anticoagulant blood, detection of genotypes at 9 loci and calculation of genetic risk factor scores

[0090] The genotypes of Zhang San’s 9 loci are: rs2123536 is CT, rs1842896 is GG, rs9349379 is AA, rs9268402 is A...

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Abstract

The invention relates to a combination of multiple genetic single nucleotide polymorphisms and environmental factors related to a coronary heart disease and application of the combination. The genetic single nucleotide polymorphisms comprise the following locus: rs2123536, rs18422896, rs9349379, rs9268402, rs12524865, rs10757274, rs1333042, rs7136259 and rs11066280; and the environmental factors comprise individual smoking, drinking and body mass index information, and blood gloucose and high density lipoprotein cholesterol value in venous blood. Based on the combination factors, a prediction model for individual level coronary heart disease is established, and the combination of the multiple genetic single nucleotide polymorphisms and the environmental factors related to the coronary heart disease has an important application prospect in assessing the coronary heart disease risk for people.

Description

technical field [0001] The present invention relates to the combination of multiple gene single nucleotide polymorphism sites and environmental factors related to coronary heart disease and its application, in particular to the single nucleotide polymorphism sites including rs2123536, rs1842896, rs9349379, rs9268402, rs12524865, rs10757274, rs1333042, rs7136259 and rs11066280 The combination of genetic factors of nucleotide polymorphism sites and individual environmental exposure factors including smoking, drinking, etc., and the application of such combination factors in assessing the risk of coronary heart disease in the population. Background technique [0002] Atherosclerotic cardiovascular and cerebrovascular diseases have become a major health problem worldwide. According to the report of the World Health Organization (WHO) in 2004, the number of deaths caused by cardiovascular diseases, mainly coronary heart disease and stroke, is as high as 17.2 million every year in...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12M1/34
Inventor 顾东风黄建凤鲁向锋王来元陈恕凤李宏帆
Owner FUWAI HOSPITAL OF CARDIOVASCULAR DESEASE CHINESE ACAD OF MEDICAL SCI
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