Composition comprising a combination of at least one proteolytic enzyme and at least one lipolytic enzyme, for use in preventing triglyceride synthesis

A technology of proteolytic enzymes and lipolytic enzymes, applied in the field of compositions, can solve problems such as product hazards

Inactive Publication Date: 2012-12-05
IMARKO RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these products are ve

Method used

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  • Composition comprising a combination of at least one proteolytic enzyme and at least one lipolytic enzyme, for use in preventing triglyceride synthesis
  • Composition comprising a combination of at least one proteolytic enzyme and at least one lipolytic enzyme, for use in preventing triglyceride synthesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Example 1: Application of proteolytic enzymes such as subtilisin and lipolytic enzymes such as Cal A of Candida anthartica, Geotrichum candidum lipase and Candida rugosa combined-induced activity of lipases) to prevent triglyceride synthesis:

[0084] Activity and test dose studies were performed using rats. These rats were divided into three groups (test conditions) of 10 rats each.

[0085] The first condition, the control group, did not receive any active product.

[0086] The other two conditions, each comprising groups of 10 rats, each received for 8 days (once a day) a mixture of 50 mg subtilisin and 100 mg Cal A lipase from Candida anthartica (for group 1), and Mixture of 50 mg subtilisin and 50 mg Geotrichum candidum lipase and 50 mg Candida rugosa lipase (for group 2).

[0087] Eight days later, all rats, including the control group, received a dose of olive oil equivalent to one tablespoon (15 ml) in humans.

[0088] After this olive oil was administered t...

Embodiment 2

[0095] Example 2: Study of 10 minipigs

[0096] The study was carried out on 10 minipigs.

[0097] The pigs were divided into four groups:

[0098] - a control pig

[0099] - Three pigs in group 1

[0100] - Three pigs in group 2

[0101] - Three pigs in group 3

[0102] Control pigs received no enzyme.

[0103] The other three conditions received preparations of the three enzymes.

[0104] Formulation 1 consisted of 10 mg subtilisin and 300 mg Cal A lipase and pancreatin. It was administered to group 1 pigs at a dose of 20 mg / kg.

[0105] Formulation 2 consisted of 10 mg subtilisin and 300 mg Candida rugosa lipase and pancreatin. It was administered to group 2 pigs at a dose of 40 mg / kg.

[0106] Formulation 3 consisted of 10 mg subtilisin and 300 mg Geotrichum candidum lipase and pancreatin. It was administered to group 3 pigs at a dose of 40 mg / kg.

[0107] The formulation was given once a day for 8 days.

[0108] Blood samples are taken every 2 hours for 2 days...

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Abstract

The present invention relates to a composition comprising a combination of at least one proteolytic enzyme, such as subtilisin, and at least one lipolytic enzyme, for use in preventing triglyceride synthesis, advantageously by degrading 2-monoacylglycerol in the intestine. The subject matter of the invention is also such a composition for use as a medicament, as a cosmetic agent, as a medical device, as a food composition, as a food supplement or else as a nutriceutical, in particular for use in preventing or treating obesity, atherosclerosis or type II diabetes, or else for use in preventing or reducing excess weight.

Description

technical field [0001] The present invention relates to a composition comprising a combination of at least one proteolytic enzyme, such as subtilisin, and at least one lipolytic enzyme, useful for the prevention of triglycerides, advantageously by degrading 2-monoacylglycerol in the intestine. Synthesis of esters. Advantageously, the composition of the invention comprises several lipases. The invention also relates to the use of this composition as a medicament, a cosmetic agent, a medical device, a dietary composition, a dietary supplement or a nutraceutical, especially for the prevention or treatment of obesity, atherosclerosis, type 2 diabetes or for the prevention or treatment of Reduce excess weight. Background technique [0002] It is generally accepted today that the increased frequency of overweight and obesity, type 2 diabetes, cardiovascular disease and low energy levels among many people in developed countries is due to poor utilization of the calories contained...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K38/46A61P3/04A23L33/00
CPCA61K38/465A61K38/46A61K38/482A61P3/04A61P3/06A61P3/08A61P3/10A61P9/10A61P43/00A61K2300/00
Inventor M·龙比
Owner IMARKO RES
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