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Coating film capable of adhering or directly adhering on blood vessel

A technology of coating and blood vessels, applied in the field of adhesive/direct adhesive coating and its preparation, can solve the problems of delayed endothelialization, complicated manufacturing process, restenosis, etc., and achieve the effect of simplifying the operation process, simple operation and low price

Active Publication Date: 2012-12-19
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because metal stents are mostly precious metals, and the manufacturing process is complicated, metal covered stents are expensive
Moreover, after the metal-covered stent is implanted in the human body, complications such as delayed endothelialization and restenosis will occur.

Method used

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  • Coating film capable of adhering or directly adhering on blood vessel
  • Coating film capable of adhering or directly adhering on blood vessel
  • Coating film capable of adhering or directly adhering on blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Step 1, take NIPAM monomer and polymerize into nanoscale PNIPAM gel;

[0028] Step 2, under the condition of 15°C, adding Glubran glue to PNIPAM to form nanogel microspheres containing Glubran glue;

[0029] In step 3, the obtained nanogel microspheres are evenly coated on the outer surface of the artificial blood vessel covering, and after drying, the directly sticking blood vessel covering containing the Glubran glue coating is constructed.

[0030] The obtained vascular membrane can be / directly pasted, the quality is reliable, and there is no defect on the surface of the vascular membrane.

[0031] Among them, the 2-methylstyryl-α-isobutyl cyanoacrylate (Glubran glue, NBCA-MS) used in this embodiment, that is, Italian glue, is an adhesive liquid embolism produced by the Italian GEM company. The material is made by adding a 2-methylstyrene on the basis of the commonly used classic embolism material α-isobutyl cyanoacrylate (NBCA). Compared with NBCA, its main advanta...

Embodiment 2

[0033] Step 1, take NIPAM monomer and polymerize into nanoscale PNIPAM gel;

[0034] Step 2, under the condition of 15 ° C, α-isobutyl cyanoacrylate is added to PNIPAM to form nanogel microspheres containing α-isobutyl cyanoacrylate;

[0035] In step 3, the obtained nanogel microspheres are evenly coated on the outer surface of the artificial blood vessel covering, and after drying, a direct-adhesive blood vessel covering containing an α-isobutyl cyanoacrylate coating is constructed.

[0036] The obtained vascular membrane can be / directly pasted, the quality is reliable, and there is no defect on the surface of the vascular membrane.

[0037] When preparing a vascular membrane that can be directly pasted, at temperatures of 10°C, 15°C, and 25°C, other compounds containing α-isobutyl cyanoacrylate structure were used as embolic materials to prepare nanogel microspheres and other conditions were not changed. In the case of changing conditions, the same reliable quality can be d...

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PUM

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Abstract

The invention provides a coating film capable of adhering or directly adhering on blood vessel. Surface of the inventive artificial blood vessel coating film is coated with a nano-gel coating layer made from mixture of adhesive embolic material and poly(N-isopropylacrylamide). After release of the adhesive embolic material in the nano-gel coating layer, the artificial blood vessel coating film is tightly bonded with blood vessel intima, and simultaneously blocks aneurysm to isolate aneurysm from blood flow. The inventive coating film has the advantages of simple operation during surgery, low cost, and high safety and reliability; is suitable for pathology such as intracranial aneurysms, carotid cavernous fistula (CCF), arteriovenous fistula, thoracic aortic aneurysm and abdominal aortic aneurysm; and has wide application in medical field.

Description

technical field [0001] The invention relates to a film that can be / directly pasted and a preparation method thereof, as well as a balloon catheter that carries a film that can be directly pasted. Specifically, it relates to a direct pasting tube for the treatment of intracranial aneurysm, carotid cavernous fistula, arteriovenous fistula, peripheral aneurysm, thoracic and abdominal aortic aneurysm, tracheal fistula, esophageal fistula and biliary tract fistula. lamination. Background technique [0002] With the development of interventional radiology technology, the application of covered stents in vascular or non-vascular diseases is becoming more and more extensive. When they are placed in human aneurysms or fistulas, they can quickly block aneurysms or fistulas and make aneurysms Or the fistula disappears, so as to achieve anatomical healing of the aneurysm or fistula. With the advancement of the manufacturing process of the covered stent, the used covered stent is also ...

Claims

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Application Information

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IPC IPC(8): A61B17/03A61F2/06A61F2/04A61L31/10A61L31/14A61L27/50A61L27/34
Inventor 李永东李明华
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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