Nano-carrier loaded with rhodiola rosea extract and preparation method and application thereof

A nano-carrier and nano-lipid carrier technology, applied in food preparation, skin care preparations, medical preparations containing active ingredients, etc., can solve the problem of no sustained release function, easy oxidation of active substances, low bioavailability, etc. question

Active Publication Date: 2013-01-16
SHANGHAI INOHERB COSMETIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are bottlenecks in the current application process as follows: no sust

Method used

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  • Nano-carrier loaded with rhodiola rosea extract and preparation method and application thereof
  • Nano-carrier loaded with rhodiola rosea extract and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Composition formula:

[0042] weight

[0043] Rhodiola Rosea Extract 2.5g

[0044] Solvent: Luba gum oil 25g

[0045] Water-in-oil emulsifier: Polyethylene glycol-30 dipolyhydroxystearate 20g

[0046] Polyglyceryl-3 Diisostearate 7g

[0047] Liquid Lipid Material: Macadamia Nut Oil 10g

[0048] Solid lipid material: Glyceryl monostearate 17.5g

[0049] Oil-in-water emulsifier: Tween 80 18g

[0050]Total 100g

[0051] The preparation method of described rhodiola rosea extract is: at room temperature, get 10 kilograms of rhodiola rosea and soak and extract with 100 kilograms of 50% alcohol for 32 hours to obtain an extract; the extract is concentrated 20 times after being filtered through a 200 mesh filter screen, The concentrated solution is adsorbed and purified by D101 macroporous resin; then eluted with alcohol with a mass concentration of 40%, and the eluate is collected to obtain the Rhodiola r...

Embodiment 2

[0059] Composition formula:

[0060] weight

[0061] Rhodiola Rosea Extract 2g

[0062] Solvent: Glyceryl Cocoate 30g

[0063] Water-in-oil emulsifier: polyethylene glycol-30 dipolyhydroxystearate 20g

[0064] Polyglyceryl-3 Diisostearate 7.5g

[0065] Liquid Lipid Material: Macadamia Nut Oil 10g

[0066] Solid Lipid Material: Glyceryl Monostearate 12.5g

[0067] Oil-in-Water Emulsifier: Laureth 18g

[0068] Total 100g

[0069] The preparation method of the Rhodiola rosea extract is as follows: at room temperature, 10 kg of Rhodiola rosea was soaked and extracted with 80 kg of 70% alcohol for 24 hours, and the residue was soaked with 80 kg of 70% alcohol for 24 hours to obtain an extract; The extract was filtered through a 200-mesh filter and concentrated 30 times, and the concentrated solution was adsorbed and purified on D101 macroporous resin; then eluted with alcohol with...

Embodiment 3

[0077] Composition formula:

[0078] weight

[0079] Rhodiola Rosea Extract 1.5g

[0080] Solvent: 1,3-butanediol 25g

[0081] Water-in-oil emulsifier: polyethylene glycol-30 dipolyhydroxystearate 20g

[0082] Polyglyceryl-3 Diisostearate 8.5g

[0083] Liquid Lipid Material: Sweet Almond Oil 10g

[0084] Solid lipid material: monoglyceride laurate 15g

[0085] Oil-in-water emulsifier: Tween 80 20g

[0086] Total 100g

[0087] The preparation method of the Rhodiola rosea extract is as follows: at room temperature, 10 kg of Rhodiola rosea was soaked and extracted with 50 kg of 40% alcohol for 20 hours, and the residue was soaked with 50 kg of 40% alcohol for 20 hours to obtain an extract; The extract was filtered through a 200-mesh filter and concentrated 40 times, and the concentrated solution was adsorbed and purified on D101 macroporous resin; then eluted with 80% alcohol...

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Abstract

The invention relates to a nano-carrier loaded with a rhodiola rosea extract. The nano-carrier comprises the following components according to the weight ratio: 0.5% to 3% of rhodiola rosea extract, 20% to 30% of solvent, 40% to 50% of emulsifier and 18% to 35% of lipid material; the lipid material is a solid and liquid mixture of a liquid lipid material and a solid lipid material, and the emulsifier comprises a water-in-oil emulsifier and an oil-in-water emulsifier. A preparation method of the nano-carrier with the rhodiola rosea extract comprises the following steps: mixing the lipid material and the emulsifier as an oil phase; adding the water-in-oil emulsifier into the solvent as an internal aqueous phase; adding internal aqueous water into a liquid state oil phase; uniformly mixing and solidifying after being cooled to room temperature; adding the water-in-oil emulsifier, uniformly mixing to obtain a lipid system, solidifying after being cooled to room temperature to obtain the nano-carrier loaded with the rhodiola rosea extract. The invention has the following advantages: the nano-carrier loaded with the rhodiola rosea extract is jointly utilized with a technology of multiple emulsion and lipid nanoparticles, the traditional liquid state oil is replaced by the mixture of the solid state oil and the liquid state oil, the internal aqueous phase as the rhodiola rosea extract is more stable than the traditional multiple emulsion, and the obtained nano-carrier loaded with the rhodiola rosea extract as a material can be added into the cosmetics and foods, so that the existing application defects are effectively solved.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetics and food preparation technology, and relates to a preparation method of a nano-scale carrier, in particular to a nano-structured lipid carrier with rhodiola rosea extract as an active ingredient, its preparation method and application . Background technique [0002] Lipid Nanoparticles (LN) technology is a nanoscale carrier system that uses highly physiologically compatible glyceride lipid materials as carrier materials and is prepared by modern nanotechnology and can be used to load active ingredients. Lipid nanoparticles have the following characteristics: 1. Possibility of realizing controllable drug release and targeted release; 2. Improved drug stability; 3. Higher drug loading; 4. Both lipophilic and hydrophilic drugs are convenient 5. The carrier has no biological toxicity; 6. The use of organic solvents is avoided; 7. Large-scale production and sterilization can be ca...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K8/14A61K36/41A61K9/127A61Q19/08A61P17/18A23L1/30
Inventor 胡国胜夏祥徐静
Owner SHANGHAI INOHERB COSMETIC
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