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Three-section two-dimensional liquid chromatogram system and application method thereof

A two-dimensional liquid chromatography, three-stage technology, used in measuring devices, instruments, scientific instruments, etc., to reduce processing steps, prolong service life, and reduce costs

Inactive Publication Date: 2013-01-16
SOOCHOW HIGH TECH CHROMATOGRAPHY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no one has organically combined three medium and low pressure liquid chromatography columns to construct an online two-dimensional preparative chromatography system for large-scale preparative production

Method used

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  • Three-section two-dimensional liquid chromatogram system and application method thereof
  • Three-section two-dimensional liquid chromatogram system and application method thereof
  • Three-section two-dimensional liquid chromatogram system and application method thereof

Examples

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Embodiment 1

[0031] Example 1: Please refer to the attached figure 1 , a three-stage two-dimensional liquid chromatography system, including a first-dimensional separation and detection system 1 and a second-dimensional separation and detection system 2, the first-dimensional separation and detection system 1 includes a first chromatographic column 10, a second chromatographic column 21, The first infusion device, the first detector 13, the first three-way valve 11 and the second three-way valve 20; the second dimension separation detection system 2 includes the second chromatographic column 21, the third chromatographic column 25, the second infusion device, The second detector 24 and the second three-way valve 20 and the third three-way valve 22 .

[0032] Wherein, the first three-way valve 11 is connected to the second three-way valve 20, the first infusion device is connected to the sampling end of the first chromatographic column 10, and an interface of the first three-way valve 11 is...

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Abstract

The invention discloses a three-section two-dimensional liquid chromatogram system and an application method thereof. The three-section two-dimensional liquid chromatogram system comprises a first dimensional separation detection system and a second dimensional separation detection system. A first chromatographic column is connected with a second chromatographic column through a first three-way valve and a second three-way valve; the second chromatographic column is connected with a third chromatographic column through a third three-way valve; a first infusion device is connected with the sample-introducing end of the first chromatographic column; the first three-way valve is connected with a first detector; the second three-way valve is connected with a second infusion device; and the sample-outputting end of a third chromatographic column is connected with a second detector. The system achieves separation capability of a high-pressure preparative liquid chromatography system and a medium-pressure preparative liquid chromatography system by combining two medium-pressure preparative liquid chromatography systems or low-pressure preparative liquid chromatography systems, has the advantage of large sample capacity of the low-pressure system and the medium-pressure system, and prolongs the service of the chromatogram columns. The system is simple in structure and wide in application range.

Description

technical field [0001] The invention relates to the field of preparative liquid chromatography systems. Specifically, it is a three-stage two-dimensional liquid chromatography system and its application method. technical background [0002] Liquid chromatography is a separation technique for the purpose of obtaining pure samples. Since it was applied to the separation of pigments in the 1930s, it has made great progress. In the 1980s, high-efficiency preparative liquid chromatography developed rapidly in the pharmaceutical industry, and in the 1990s, it was widely used in the separation and purification of proteins. Today, preparative chromatography is used in almost every field of social production and life, such as the separation and purification of secondary metabolites, natural products, macromolecular compounds, and some important pharmaceutically active proteins, biotherapeutics, and diagnostic reagents. However, compared with analytical chromatography, the separatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/60
Inventor 张维冰邵平戈兆松刘翻张权青
Owner SOOCHOW HIGH TECH CHROMATOGRAPHY
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