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Technology for preparing hydroxychloroquine sulfate tablets

A technology of hydroxychloroquine sulfate tablets and hydroxychloroquine sulfate, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, and pill delivery, which can solve the difficulties of industrial production and storage of tablets and the stability of quality impact, strong corrosion of metal equipment and other issues, to achieve good business prospects, good stability, and low hygroscopicity

Active Publication Date: 2013-02-13
湖北舒邦药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydroxychloroquine sulfate is easily dissociated into hydroxychloroquine and sulfuric acid after absorbing water. Sulfuric acid is extremely corrosive to metal equipment. It is precisely because of this high hygroscopicity and dissociation of hydroxychloroquine sulfate that it is difficult for industrial production and storage of its tablets. have brought great difficulties
At present, domestically produced hydroxychloroquine sulfate tablets have strong hygroscopicity, which is not conducive to the storage of the drug, and will also have a certain impact on its quality stability

Method used

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  • Technology for preparing hydroxychloroquine sulfate tablets
  • Technology for preparing hydroxychloroquine sulfate tablets
  • Technology for preparing hydroxychloroquine sulfate tablets

Examples

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Effect test

Embodiment 1

[0033] Example 1 Treatment process of hydroxychloroquine sulfate crude drug

[0034] Take the hydroxychloroquine sulfate raw material, granulate it with absolute ethanol as a wetting agent, dry it at 45°C, and sizing to make the particle size range from 40 to 80 meshes to obtain the processed hydroxychloroquine sulfate raw material.

Embodiment 2

[0035] Example 2 Treatment process of hydroxychloroquine sulfate crude drug

[0036] Take the hydroxychloroquine sulfate raw material, granulate it with absolute ethanol as a wetting agent, dry it at 60°C, and sizing to make the particle size range from 40 to 80 meshes to obtain the processed hydroxychloroquine sulfate raw material.

Embodiment 3

[0037] Example 3 Treatment process of hydroxychloroquine sulfate crude drug

[0038] Take the hydroxychloroquine sulfate raw material, granulate it with absolute ethanol as a wetting agent, dry it at 75°C, and sizing to make the particle size in the range of 40-80 mesh to obtain the processed hydroxychloroquine sulfate raw material.

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Abstract

The invention discloses a technology for treating a hydroxychloroquine sulfate raw medicament. The treatment technology comprises the following steps of: performing wet granulation on the hydroxychloroquine sulfate raw medicament by using absolute ethanol as a wetting agent, and drying. The moisture absorption of the hydroxychloroquine sulfate treated by the treatment technology is obviously reduced. The invention also discloses a method for preparing the hydroxychloroquine sulfate tablets by using the hydroxychloroquine sulfate obtained by the treatment technology. The method is easy to operate, can be used for well solving the adaptability with equipment in granulation and tabletting processes, improving the reproducibility of the process and stability of the quality, and has a good commercial prospect.

Description

Technical field [0001] The invention relates to a treatment process of hydroxychloroquine sulfate raw material medicine capable of reducing hygroscopicity, a preparation method of hydroxychloroquine sulfate tablets based on the treatment process, and hydroxychloroquine sulfate tablets prepared by the preparation method. Background technique [0002] Quinine was first used to treat lupus erythematosus skin lesions in 1894, and antimalarial drugs have been used to treat rheumatic diseases for more than 100 years. In the 1950s, antimalarials began to be widely used to treat systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine belongs to the 4-aminoquinoline class of antimalarial drugs. Because of its good safety, reliable efficacy, and its synergistic effect with immunosuppressants and glucocorticoids, it can reduce the adverse effects of the latter. It has been more and more widely used in the field of clinical rheumatism. [0003] Hydroxychloroquine sulfate is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/16A61K47/10A61K31/4706A61P19/02A61P29/00A61P19/04A61P37/06A61P33/06
Inventor 谢斌任霞罗甘树
Owner 湖北舒邦药业有限公司
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