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Extraction process of effective ingredients of gynostemma pentaphylla

A technology of active ingredients and extraction process, applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, plant raw materials, etc., can solve the problems of small production scale, difficult operation, and low extraction rate , to improve work efficiency, facilitate preservation and eliminate oxygen

Inactive Publication Date: 2013-02-27
YUNNAN NANCAN BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned prior art has made progress in extracting the active ingredients of Gynostemma pentaphyllum, avoided the precipitation of tannin to a certain extent, and removed part of the bitter taste, but because of using a large amount of ethanol and other organic solvents in the extraction, to make the recovery process relatively difficult. Complicated, the production scale is small, and the process conditions are not easy to control, and the operation is difficult
Although the decoction extraction method is simpler than the ethanol extraction method, the extraction rate is not high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Gynostemma pentaphyllum is broken to 80 orders, add the Na that pH value is 7.5 2 CO 3 Leach in weakly alkaline solution, the weight ratio of weakly alkaline solution to Gynostemma pentaphyllum is 1.5:1, leaching for 30 minutes under heating and boiling, adding citric acid to adjust the pH to 4.5, and then adding 0.1% of the solution weight CTS flocculant After standing for 2 hours, precipitate and filter to obtain the supernatant containing the active ingredient of Gynostemma pentaphyllum.

Embodiment 2

[0018] Example 2: Break Gynostemma pentaphyllum to 150 mesh, add NaOH weak alkaline solution with a pH value of 8 for extraction, the weight ratio of weak alkaline solution to Gynostemma pentaphyllum is 2:1, and extract for 60 minutes under heating and boiling. Add malic acid to adjust the pH to 5, then add 0.5% PACS synergistic flocculant by weight of the solution, let it stand for 2 hours, precipitate and filter, and obtain the supernatant containing the active ingredient of Gynostemma pentaphyllum.

Embodiment 3

[0019] Embodiment 3: Gynostemma pentaphyllum is broken to 80 orders, add the Na that pH value is 8.5 2 CO 3 Leach in weakly alkaline solution, the weight ratio of weakly alkaline solution to Gynostemma pentaphyllum is 3:1, leaching for 100 minutes under heating and boiling, adding citric acid to adjust the pH to 4.7, and then adding 1% diatoms by weight of the solution The soil precipitation filter aid is left to stand for 2 hours, precipitated and filtered to obtain a supernatant liquid containing the active ingredient of Gynostemma pentaphyllum.

[0020] The extraction results of the above process of the present invention and the existing water decoction method and alcohol extraction method are shown in the table below. The results show that the saponin amount and dissolution rate extracted by the process of the present invention are the highest, the alcohol extraction method is second, and the water decoction method is the lowest.

[0021] Extract comparison table:

[002...

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PUM

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Abstract

The invention discloses an extraction process of effective ingredients of gynostemma pentaphylla, and relates to the extraction process of effective ingredients of gynostemma pentaphylla. The method provided by the invention comprises the following steps of: heating crashed gynostemma pentaphylla in an alkalescent medium with the pH value of 7.5-8.5 until the crashed gynostemma pentaphylla is boiled, and digesting; then adding edible acid to regulate the pH value to be 4.5-5.0; adding 0.01-1% of precipitate filter aid into digestion liquid; and standing, precipitating, and filtering, thereby obtaining the extraction liquid containing the effective ingredients of gynostemma pentaphylla. Compared with the prior art, the extraction process of effective ingredients of gynostemma pentaphylla provided by the invention has the advantages that the extraction rate is high, the time is short, and impurity removing, tannin removing and debittering efficiencies are high.

Description

technical field [0001] The invention relates to an extraction process specially aimed at the main effective components of Gynostemma pentaphyllum. Background technique [0002] Gynostemmapentu phylum (Thurb) Makino] is a perennial herbaceous vine of the genus Gynostemma Bl of the family Cucurbitaceae, also known as Aescin. It is mostly produced in the vast areas south of the Yangtze River in my country, because it is rich in ginsenosides , Known as "Southern Ginseng". [0003] More than 80 species of Gypenosides have been extracted from Gynostemma pentaphyllum, all of which belong to the structure of dammarate alkanols. The total saponin content of Gynostemma pentaphyllum is three times that of ginseng, but there is no side effect of overdose of ginseng. Pharmacological studies have proved that Gynostemma pentaphyllum has the effects of clearing heat and detoxifying, relieving cough and expectorant, lowering blood fat, calming the nerves, and resisting arteriosclerosis. Ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/424
Inventor 谢檵厵
Owner YUNNAN NANCAN BIOLOGICAL ENG CO LTD
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