Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Caspase-1 inhibitor targeting liver and application thereof

A technology of pre-s1 and inhibitors, applied in enzyme inhibitors and in the fields of medicine and biomedicine, can solve problems such as difficult termination of chronic hepatitis B, and achieve the effect of reducing production, reducing internal environment disorders and immunodeficiency

Active Publication Date: 2013-03-20
ARMY MEDICAL UNIV
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have found that even if the virus replication is effectively inhibited, it is difficult to stop the malignant course of chronic hepatitis B from progressing to cirrhosis / liver failure, which is precisely the main harm of chronic hepatitis B
At present, there are no effective therapeutic strategies and drugs that can block the malignant progression of chronic hepatitis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Caspase-1 inhibitor targeting liver and application thereof
  • Caspase-1 inhibitor targeting liver and application thereof
  • Caspase-1 inhibitor targeting liver and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The experimental methods for which specific conditions are not indicated in the preferred embodiments are usually in accordance with conventional conditions, or in accordance with the conditions suggested by the manufacturer.

[0019] 1. Preparation of liver-targeted caspase-1 inhibitors

[0020] Design and entrust Sangon Bioengineering (Shanghai) Co., Ltd. to synthesize a liver-targeting caspase-1 inhibitor whose amino acid sequence is shown in SEQ ID No.1. In the sequence shown in SEQ ID No.1, amino acids 1-50 are derived from the amino acid sequence 1-50 of the Pre-S1 protein of hepatitis B virus strain FMC#97, and amino acids 51-53 are flexible Linker, the 54th-65th amino acid is a trimolecular polymer of YVAD (Tyr-Val-Ala-Asp) tetrapeptide, the 66th-68th amino acid is a flexible linker, and the 69th-77th amino acid is VAD (Val-Ala-As...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a caspase-1 inhibitor targeting liver. The caspase-1 inhibitor is formed by connection of human hepatitis B virus Pre-S1 peptide and caspase-1 inhibitor through a flexible connector, wherein the Pre-S1 peptide consists of amino acids from first to fiftieth of the Pre-S1 protein; and the caspase-1 inhibitor is formed by connection of trimolecular polymer of YVAD tetrapeptide and trimolecular polymer of VAD tripeptide. According to the inhibitor, the caspase-1 inhibitor is specifically targeted to a liver cell by utilizing the carrier Pre-S1 peptide which specifically targets liver, so that intrahepatic persistent chronic inflammation caused by endogenous danger signals released by injured liver cells can be blocked by terminating caspase-1 activation in the liver cell, sequential spinal cord injury of the liver cell can be blocked, body adverse response which is possibly caused by spread inhibition of caspase-1 can be reduced, and the liver cell can be specifically and effectively protected. The caspase-1 inhibitor can be used for preparing a medicament for treating intrahepatic chronic inflammation caused by endogenous danger signals released by injured liver cells.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to an enzyme inhibitor and its application in the field of medicine. Background technique [0002] Chronic liver injury mainly caused by chronic hepatitis is a major health problem in my country, and it is also one of the main causes of human death announced by the World Health Organization. Once chronic liver inflammation starts, it is difficult to stop, and further causes liver cirrhosis, liver failure, and liver cancer, which is called the "trilogy of chronic liver disease"; trauma". [0003] Previous studies have believed that the activity of the virus in the liver is an important reason for the persistence of intrahepatic inflammation, so antiviral therapy is currently the most commonly used method for the treatment of chronic hepatitis B. However, studies have found that even if the virus replication is effectively inhibited, it is difficult to stop the malignant course of chronic h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07K19/00A61K38/16A61K47/48A61P1/16A61P29/00
Inventor 王靖雪吴玉章刘钱刘宏利
Owner ARMY MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com