Application of salidroside in hepatic stellate cell migration inhibition drug preparation

A hepatic stellate cell and salidroside technology, which is applied in the field of traditional Chinese medicine and can solve the problems of hepatic stellate cell migration that have not been reported.

Inactive Publication Date: 2013-03-27
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the role of salidroside in inhibiting the migration of hepatic stellate cells

Method used

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  • Application of salidroside in hepatic stellate cell migration inhibition drug preparation
  • Application of salidroside in hepatic stellate cell migration inhibition drug preparation
  • Application of salidroside in hepatic stellate cell migration inhibition drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] The salidroside of the present invention is made into tablets according to methods known to those skilled in the art. Salidroside tablets, each tablet contains salidroside 100mg, microcrystalline cellulose 100mg, micropowder silica gel 40mg, lactose 20mg, magnesium stearate 1.0mg Usage: 4-5 tablets each time, 2-3 times a day , medication 5-6 days a week, every 3-4 weeks as a course of treatment.

Embodiment 2

[0105] The salidroside of the present invention is made into capsules according to methods known to those skilled in the art. Salidroside capsules, each containing 100mg of salidroside. Usage: 4-5 capsules each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

Embodiment 3

[0107]The salidroside of the present invention is made into granules according to methods known to those skilled in the art. Salidroside granules, each bag contains salidroside 500mg, microcrystalline cellulose 100mg, micropowder silica gel 40mg, stearic acid 1.0mg, lactose 20mg. Usage: 1 bag each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

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Abstract

The invention discloses an application of salidroside in hepatic stellate cell migration inhibition drug preparation. According to the present invention, a PDGF-induced human hepatic stellate cell line (LX-2) migration screening platform is designed, and results show that PDGF-induced hepatic stellate cell (HSC) migration can be inhibited with 10<-4>-10<-7> mol / L salidroside.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of salidroside in the preparation of medicines for inhibiting the migration of hepatic stellate cells. Background technique [0002] Salidroside is a natural product isolated and purified from Rhodiola rosea. It has various pharmacological effects such as anti-fatigue, anti-aging, immune regulation, scavenging free radicals, enhancing memory, improving sleep, eliminating depression and protecting cardiovascular. Years of research have found that salidroside also has the effect of resisting liver fiber and improving liver damage. Wang Xiaodong et al respectively used CCl 4 , D2 galactosamine, and BCG-plus lipopolysaccharide-induced liver injury model in mice, using ALT, NO, MDA, and triglyceride (Triglyceride, TG) content as indicators to observe the protective effect of salidroside on liver injury. The results showed that Salidroside can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P1/16
Inventor 徐列明张展
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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