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Compound nucleotide immunoenhancer for paralichthys olivaceus

An immune enhancer and nucleotide technology, applied in the application, active ingredients of heterocyclic compounds, medical preparations containing active ingredients, etc., can solve water environmental pollution, decreased immunity of aquaculture animals, and affect the quality of aquatic products, etc. problems, to achieve the effects of no pollution to the environment, no toxic and side effects, and improved food intake and growth

Inactive Publication Date: 2014-04-09
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of antibiotics can easily lead to drug resistance, resulting in a decline in the immunity of aquaculture animals, seriously affecting the quality of aquatic products, especially leading to environmental pollution of the entire water body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weighed 60 g of cytosine nucleotide, 8 g of uracil nucleotide, 10 g of thymine nucleotide, 2 g of hypoxanthine nucleotide (IMP) and 20 g of bioactive peptides purchased from Beijing Sangpu Biotechnology Co., Ltd., the mixture was ground and pulverized, and then sieved with a sieve, wherein the fineness of the sieve was required to be 80-120 mesh. The filtered powder is dried until the weight of the powder is reduced by 10% compared with that before drying; thus the required immune enhancer is prepared.

Embodiment 2

[0015] Weighed 55g of cytosine nucleotides, 10g of uracil nucleotides, 15g of thymine nucleotides, 5g of inosine nucleotides and 5g of inosine nucleotides purchased from Shandong Shuangfeng Co., Ltd. Bioactive Peptides of Technology Ltd. 15g. The fineness requirement is 80-120 mesh, and the loss on drying is ≤10.0%. Get the needed immune booster.

Embodiment 3

[0017] Weighed 65 g of cytosine nucleotides, 5 g of uracil nucleotides, 15 g of thymine nucleotides, 3 g of inosine nucleotides and 3 g of inosine nucleotides purchased from Shandong Shuangfeng Co., Ltd. Bioactive Peptides of Technology Ltd. 12g. The fineness requirement is 80-120 mesh, and the loss on drying is ≤10.0%. Get the needed immune booster.

[0018] The use method and dosage of the above-mentioned immune enhancer are as follows: add 0.2-0.5 g of the immune enhancer to each kilogram of flounder feed, and make pellet feed for feeding.

[0019] The present invention will be further described below in conjunction with the non-specific immune index and disease resistance obtained from the compound nucleotide immune enhancer feeding test.

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Abstract

The invention relates to a compound nucleotide immunoenhancer for paralichthys olivaceus, which is composed of the following substances in percentage by weight: 55-65% of cytidylate, 5-15% of uridine monophosphate, 5-15% of thymidine phosphorylase, 1-5% of hypoxanthine nucleotide and 10-20% of bioactive peptide. The compound nucleotide immunoenhancer disclosed by the invention is capable of obviously improving the ingestion and the growth of paralichthys olivaceus, and remarkably improving the cellular immunity, the humoral immunity, the immune gene expression quantity, the disease resistance and the like of paralichthys olivaceus. Moreover, the compound nucleotide immunoenhancer can also be directly added in a feed for paralichthys olivaceus, and orally fed; and the compound nucleotide immunoenhancer has the advantages of being free from toxic and side residues, free from drug resistance, and pollution-free to environment.

Description

technical field [0001] The invention belongs to the technical field of feed additives, and in particular relates to a compound nucleotide immune enhancer for flounder. Background technique [0002] Flounder is one of the important seawater cultured fishes in my country, with delicious meat and rich nutritional value. With the increasing scale and density of flounder factory farming, the incidence of disease is also increasing, which has brought great economic losses to the breeding industry. Farmers have to use antibiotics to prevent and treat diseases. However, long-term use of antibiotics can easily lead to drug resistance, resulting in a decline in the immunity of aquaculture animals, seriously affecting the quality of aquatic products, especially leading to environmental pollution of the entire water body. Therefore, the development and use of green pollution-free immune enhancer has become a trend. Contents of the invention [0003] The object of the present invent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/52A61K31/7068A61K31/7072A23K1/16A23K1/18
Inventor 王正丽杨宁
Owner QINGDAO AGRI UNIV
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