Brain nucleus Granger causal analysis method based on obesity model Prader-Willi syndrome (PWS)

Abstract

The invention discloses a brain nucleus Granger causal analysis method based on obesity model Prader-Willi syndrome (PWS). The method comprises steps of obtaining functional magnetic resonance data through a resting state scanning method, and preprocessing data, wherein the processing comprises steps of time correction, head movement aligning, space standardization and spatial smoothing; conducting Amplitude Of Low Frequency Fluctuation (ALFF) analysis for preprocessed data, and defining regions of interest in accordance with a brain difference region of a PWS patient and a normal control group; and conducting the Granger causal analysis, selecting two regions from regions of interest, extracting time sequences of two regions, calculating the Granger causal value between two regions through a two-phase autoregression module, and conducting normalization for the Granger causal value. By the aid of the method, the abnormal drive action of amygdaloid nucleus on hypothalamus is found, the energy balance of the hypothalamus is damaged, the PWS patient overeats and is fat, the target spot is found for the clinical treatment, the iconography evidence is provided and the good research result is obtained.

Description

technical field [0001] The invention belongs to the technical field of medical image processing and analysis, relates to a Granger causal analysis method for the interaction relationship between brain nuclei of an obesity model (Prader-Willi syndrome, PWS), and can be used for pathogenic mechanisms The identification and extraction of brain targets and the description of the causal relationship between nuclei can provide imaging evidence for clinical treatment. Background technique [0002] At present, all countries in the world are facing the global problem of obesity, which is the third most threatening factor to human health after cardiovascular disease and cancer. The number of obese people in the world has exceeded 400 million (about 6% of the total population) and about 1.6 billion overweight people (about 24% of the total population). Obese people, and by the end of 2008, the number of obese people in my country has exceeded 90 million, and the number of overweight pe...

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Problems solved by technology

The above literatures are only studied from the perspective of picture stimulation, and have not been studied from the internal physiological baseline level of PWS patients.

In addition, the above studies only found differences in the functions of brain nuclei through image stimulation, and did not conduct an overall study from the perspective of the brain functional network (that is, the circuit), let alone conduct in-depth and detailed research from the perspective of the mutual causal relationship between the nuclei in the circuit. Because the relationship between nuclei plays a vital role in explaining the pathogenic mechanism and clinical treatment

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