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Reinforced non-disintegrative calcium-based bone cement preparation

A bone cement and preparation technology, applied in surgical adhesives, medical science, prosthesis, etc., can solve problems such as easy disintegration

Active Publication Date: 2015-04-01
NAT CHENG KUNG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this low-viscosity bone cement paste disintegrates easily when it comes in contact with water, body fluids or blood immediately after injection

Method used

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  • Reinforced non-disintegrative calcium-based bone cement preparation
  • Reinforced non-disintegrative calcium-based bone cement preparation
  • Reinforced non-disintegrative calcium-based bone cement preparation

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] Preparation of TTCP powder

[0037] TTCP powder adopts the method proposed by Brown and Epstein [Journal of Research of the National Bureau of Standards-A Physics and Chemistry 6 (1965) 69A 12], from dicalcium pyrophosphate (Ca 2 P 2 o 7 ) (Alfa.USA) and calcium carbonate (CaCO 3 ) (Katayama Chem.Co., Japan, Tokyo) reaction and self-made.

[0038] TTCP powder by adding Ca 2 P 2 o 7 Powder with CaCO 3 The powder was prepared by uniform mixing for 12 hours. Ca 2 P 2 o 7 Powder with CaCO 3 The mixing ratio of the powders was 1:1.27 (weight ratio), and the powder mixture was heated to 1400° C. to react the two powders to form TTCP.

[0039] Preparation of TTCP / DCPA and TTCP / DCPA / CSH powder

[0040] An appropriate amount of TTCP and DCPA powders were uniformly mixed in a ball mill at a molar ratio of 1.0 to obtain TTCP / DCPA powders. The TTCP / DCPA powder is then uniformly mixed with an appropriate amount of CSH powder to obtain a TTCP / DCPA / CSH mixed powder.

[...

Embodiment 1

[0051] Embodiment 1: TTCP / DCPA:CSH=65:35 powder component and 0.45M (NH 4 ) 2 HPO 4 Coagulation solution, L / P=0.35cc / g

[0052] In this example, 0.45M (NH 4 ) 2 HPO 4 Aqueous solutions were used to examine the effect of PAA on the disintegration properties of bone cement pastes.

[0053] Table 1: TTCP / DCPA:CSH=65:35, 0.45M (NH 4 ) 2 HPO 4 , L / P=0.35cc / g

[0054]

[0055] * PAA concentration (wt%) is based on the total weight of bone cement paste

[0056] The data shown in Table 1 can be summarized as follows:

[0057] 1. A small amount of PAA can dramatically and effectively reduce the degree of disintegration of the bone cement paste.

[0058] 2. The working time / setting time (WT / ST) starts to shorten significantly when the amount of PAA equals to more than 5% by volume.

Embodiment 2

[0059] Embodiment 2: TTCP / DCPA:CSH=65:35 powder component and 0.45M (NH 4 ) 2 HPO 4 Coagulated aqueous solution, L / P=0.30cc / g

[0060] This example is similar to Example 1, except that L / P=0.35cc / g is changed to L / P=0.30cc / g and the PAA concentration is up to 5% by volume.

[0061] Table 2: TTCP / DCPA:CSH=65:35, 0.45M (NH 4 ) 2 HPO 4 , L / P=0.30cc / g

[0062]

[0063] * PAA concentration (wt%) is based on the total weight of bone cement paste

[0064] a)，b) figure 1 (a) and (b) respectively show the photos of the bone cement paste green body injected in Hanks' physiological solution

[0065] The data shown in Table 2 can be summarized as follows:

[0066] 1. A small amount of PAA can dramatically and effectively reduce the degree of disintegration of the bone cement paste.

[0067] 2. The working time / setting time (WT / ST) starts to shorten significantly when the amount of PAA equals to more than 3% by volume.

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Abstract

The invention provides a calcium-based bone cement preparation with powder components and solidified liquid components, wherein the ratio of liquid to powder is 0.2cc / g to 0.5cc / g, and the powder components contain tetracalcium phosphate. The bone cement preparation further contains 0.01%-1% polyacrylic acid with a repeated unit -(CH2-C(COOH)H)n- based on the total weight of the bone cement preparation, wherein the n equals to 50-50000.

Description

technical field [0001] Exemplary embodiments of the present invention relate to bone repair substances for use in medicine, and more particularly, exemplary embodiments of the present invention relate to a bone cement formula. Background technique [0002] Bone cement compositions are widely used to bond, fill and / or repair damaged natural bone. Bone cements are commonly used in orthopedic, dental procedures and / or other medical applications. [0003] The applicant of the present case disclosed a bone cement preparation with a powder component and a coagulation liquid component in the Chinese invention patent application number 201010541397.7, wherein the powder component contains a calcium sulfate source and a calcium phosphate source to Based on the total weight of calcium sulfate source and calcium phosphate source, the weight ratio of said calcium sulfate source is less than 65%, and said coagulating liquid component contains ammonium ion (NH 4 + ), wherein the calciu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/06A61L24/02A61L27/16A61L27/12A61L27/02A61L27/50
Inventor 陈瑾惠朱建平
Owner NAT CHENG KUNG UNIV