Cavity-type dynamic-filling bioreaction device

Abstract

The invention provides a cavity-type dynamic-filling bioreaction device comprising a biological sample culture component, a nutrient solution flowing pipe and a power pump component. The biological sample culture component is provided with an in-out port communicated with the nutrient solution flowing pipe. The biological sample culture component comprises an upper cover body, a container body and a sample bearing frame, wherein the upper cover body is connected with the container body, a supporting ring is arranged on the inner wall of the container body, the sample bearing frame is arranged on the supporting ring, a supporting block is arranged on the inner side of the sample bearing frame, a sample bearing plate is arranged in a cavity formed by the supporting block and the sample bearing frame, and culture through holes are longitudinally formed in the sample bearing plate. The nutrient solution flowing pipe comprises an output pipe and an input pipe, wherein the output pipe and the input pipe are respectively connected with the power pump component.

Description

technical field [0001] The present invention relates to a device for cultivating samples in the fields of plant, animal and human tissue engineering, and in particular to a cavity-type device that promotes the proliferation and differentiation of cells and tissues by continuously and dynamically supplying nutrients and regulating the stimulation of mechanics and biologically active substances. Dynamic perfusion biological tissue reaction device. Background technique [0002] Tissue engineering combines the principles of cell biology and engineering to study the anatomical structure and physiological functions of normal cells, tissues or organs, so as to produce artificial substitutes that can improve, repair or rebuild the structure and function of damaged tissues. The method is to obtain a small amount of tissue from the body, obtain seed cells after separation and expansion, inoculate them into biological scaffolds, form tissue engineering components through in vitro cultu...

AI Technical Summary

Problems solved by technology

[0006] Although the existing bioreactors can already provide a three-dimensional culture environment for cells on tissue-engineered bioscaffolds, they either cannot distribute the cells evenly in the bioscaffolds, or they need to be reorganized when constructing cell-bioscaffold complexes of different specifications. Custom-made reactors and the ability to construct only hollow cell-bioscaffold complexes limit mass production of tissue engineered products

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