Biomedical nuclear magnetic resonance device

Abstract

The invention discloses a biomedical nuclear magnetic resonance device which comprises a frequency meter, a radiofrequency oscillator, a radiofrequency coil, a modulation receiver, a sample tube, a first magnet and a second magnet. The radiofrequency coil generates an alternating electromagnetic field according to pulse current from the radiofrequency oscillator, inductively generates sample feedback signals which represent the energy level of nuclear spin of a sample and comprises an even number of rectangular secondary coils, a long side of each rectangular secondary coil extends to form a first transmission line positioned in the axis of the radiofrequency coil, a short side, which is adjacent to the corresponding long side, of each rectangular secondary coil is bent and then extends to form a second transmission line, and the rectangular secondary coils are connected with one another in parallel and are equidistantly arranged to form the radiofrequency coil; the modulation receiver is connected to the radiofrequency oscillator; the sample tube is positioned on the axial line of the radiofrequency coil, is positioned under the radiofrequency coil and is mounted on a rotor fixing part; and the first magnet and the second magnet are respectively positioned on two sides of the sample tube. The biomedical nuclear magnetic resonance device has the advantages that the biomedical nuclear resonance device is high in quality factor, high-power excitation and excellent radiofrequency magnetic field distribution are realized, the measuring accuracy and the measuring sensitivity are greatly improved, the stability of a sample is improved when the sample rotates, and the jamming rate during sample loading is reduced.

Description

technical field [0001] The invention relates to the field of nuclear magnetic resonance analysis devices, in particular to a nuclear magnetic resonance device used in biomedicine. Background technique [0002] In view of the wide application of nuclear magnetic resonance technology in basic research such as chemistry and biology, as well as in clinical medicine and drug development, various high-resolution nuclear magnetic resonance analysis techniques have become important tools in biochemical research. To obtain high-quality NMR spectra, parameters such as the variable temperature performance and rotation stability of the NMR rotor adapter are very important. In particular, if you want to obtain high-resolution NMR spectra, you need to use a rotor adapter with a large temperature range (-200 to 200°C) and rotate the sample (greater than 20 rpm). At this time, you need to ensure the stability of the sample tube during rotation. sex. The magnetic susceptibility and mass di...

AI Technical Summary

Problems solved by technology

The current common RF coils, such as solenoid RF coils and Helmholtz RF coils, can apply a maximum RF field strength of 10~15kHz, which does not meet the requirements for applying higher power RF fields, making Performing high-resolution NMR experiments becomes difficult

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