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Composition for treating hyperlipidemia and atherosclerosis and application of composition

A technology of atherosclerosis and composition, which is applied in the field of biomedicine to achieve the effects of reducing drug costs, wide sources, and reducing dosage

Active Publication Date: 2013-08-14
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of artemisinin and its derivatives in reducing blood lipid and anti-atherosclerosis has not been reported.

Method used

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  • Composition for treating hyperlipidemia and atherosclerosis and application of composition
  • Composition for treating hyperlipidemia and atherosclerosis and application of composition
  • Composition for treating hyperlipidemia and atherosclerosis and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 40 ApoE knockout mice were fed adaptively for 1 week, and the ApoE knockout mice were divided into model group, artesunate group (10 mg / kg), atorvastatin group (10 mg / kg) and compound group ( Atorvastatin: artesunate 1:1, 10mg / kg), 10 mice in each group, were given high-fat diet; apoE knockout mice were fed with high-fat diet to form an atherosclerosis model, and at the same time were given different doses according to grouping. After 2 months of treatment, blood was taken from the fundus vein of the mice, and the triglyceride and cholesterol in the serum were determined by figure 1 It can be seen that the compound group can effectively reduce the levels of cholesterol and triglyceride in mice.

[0031] Separate the aorta and observe the plaque area with oil red staining; figure 2 shown by figure 2 It can be seen that the compound group can effectively reduce the area of ​​atherosclerotic plaque, and the effect is better than that of the atorvastatin group and the a...

Embodiment 2

[0034] Atorvastatin 10g, artesunate 10g, hypromellose 80g, polyvinylpyrrolidone 100g, lactose 85g, micronized silica gel 100g. Mix the prescribed amount of atorvastatin and artesunate with the slow-release agent (hydroxypropyl methylcellulose and lactose), add the binder polyvinylpyrrolidone plasmid, and dry at 40°C to 80°C. For dry granules, add the prescribed amount of lubricant micro-powdered silica gel to the dry granules, mix well, and punch out shaped tablets.

Embodiment 3

[0036] Atorvastatin 1g, artesunate 10g, hypromellose 80g, polyvinylpyrrolidone 100g, lactose 85g, micronized silica gel 100g. Mix the prescribed amount of atorvastatin and artesunate with the slow-release agent (hydroxypropyl methylcellulose and lactose), add the binder polyvinylpyrrolidone plasmid, and dry at 40°C to 80°C. For dry granules, add the prescribed amount of lubricant micro-powdered silica gel to the dry granules, mix well, and punch out shaped tablets.

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Abstract

The invention discloses a composition for treating hyperlipidemia and atherosclerosis and application of the composition. The composition comprises atorvastatin or medicinal salt of the atorvastatin and artesunate which are of 1: 10 to 10: 1 in weight ratio. The composition can be used for preparing a medicine for treating and preventing the hyperlipidemia and atherosclerosis. Compared with the prior art, the medicine composition is capable of effectively reducing the lipid of a model animal suffering from atherosclerosis and lowering the area of atherosclerotic plaque, has the effect superior to single component in the composition, and also can decrease the usage amount of medicines under the synergistic interaction, thereby reducing the toxic and side effects and decreasing the medication cost.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a composition for treating hyperlipidemia and atherosclerosis and its application. Background technique [0002] Atherosclerosis (AS) is a common cardiovascular disease in modern society, mainly manifested as lipid deposition in the arterial intima, focal fibrosis in the intima, and formation of atherosclerotic plaques, resulting in hardening of the vessel wall and the deterioration of the lumen. Stenosis, and then cause a series of secondary lesions, especially easy to cause ischemic diseases in cardiovascular and cerebrovascular, etc., is the number one killer of human beings in today's society. The pathogenesis of atherosclerosis is complex, and hyperlipidemia and inflammation are considered to be the two most important pathogenic factors. The current main strategy to prevent and treat atherosclerosis is lipid-lowering. There are five types of lipid-lowering drugs commonly used: st...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61P3/06A61P9/10A61K31/40
Inventor 唐克轩王玉亮
Owner SHANGHAI JIAO TONG UNIV
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