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Traditional Chinese medicinal extract product used for treating urinary incontinence, and active component thereof

A technology of active ingredients and urinary incontinence, applied to the field of active ingredients contained in extracts, Chinese medicine extracts, can solve problems such as unclear material basis

Active Publication Date: 2013-09-04
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The material basis for this compound to exert the above effects is not yet clear

Method used

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  • Traditional Chinese medicinal extract product used for treating urinary incontinence, and active component thereof
  • Traditional Chinese medicinal extract product used for treating urinary incontinence, and active component thereof
  • Traditional Chinese medicinal extract product used for treating urinary incontinence, and active component thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Take 500g of Yizhiren, dry it at low temperature and pulverize it, add 3000mL of 60% ethanol to extract under reflux for 1 hour, filter, add 2000mL of 60% ethanol to the filter residue and extract under reflux for 1 hour, filter, combine the two filtrates, reduce The ethanol is recovered under pressure until there is no alcohol smell, heated in a water bath to concentrate, and the ethanol extract of Yizhiren is obtained with a yield of 11.2%.

Embodiment 2

[0041] Example 2 Take 500g of Yizhiren, dry it at low temperature and pulverize it, add 4000mL of 95% ethanol to extract under reflux for 1 hour, filter, add 2000mL of 95% ethanol to the filter residue and extract under reflux for 1 hour, filter, combine the two filtrates, reduce The ethanol is recovered under pressure until there is no alcohol smell, heated in a water bath to concentrate, and the ethanol extract of Yizhiren is obtained with a yield of 12.8%.

Embodiment 3

[0042] Example 3 Take 25 kg of Yi Zhi Ren, dry it at low temperature, crush it, extract it twice with 75% ethanol under reflux, recover the ethanol under reduced pressure, dilute with distilled water, extract with petroleum ether, recover the solvent, and obtain 429 g of petroleum ether extract. Take 250 g of the petroleum ether extract, separate it on a silica gel column chromatography, use petroleum ether-ethyl acetate (1:0~0:1) gradient elution, collect the eluent in sections, and apply the eluent to the preparative high performance liquid chromatography Separation and preparation, collecting samples in sections according to absorption peaks, and concentrating. Isaxanthin was obtained after identification by thin-layer chromatography.

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Abstract

A traditional Chinese medicine Fructus Alpiniae Oxyphyllae ethanol extract product contains an active component izalpinin, has a bladder smooth muscle muscarine acceptor antagonism effect, and can be used for treating the urinary incontinence.

Description

technical field [0001] The invention provides a traditional Chinese medicine extract for treating frequent urination and urgency caused by overactive bladder, especially the active ingredients contained in the extract, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Overactive bladder (OAB) is a syndrome characterized by symptoms of urinary urgency, often accompanied by frequency and nocturia, with or without urge incontinence [1] . The incidence of OAB exceeds 16% in the United States [2] , 11.8% in Europe and 12.2% in South Korea [3] , there is a clear tendency to increase with age [4] . In China, in 2005, the Department of Obstetrics and Gynecology of the Fuzhou General Hospital of the Nanjing Military Region officially released a survey showing that 18.2% of adult women in our country suffer from urinary incontinence, and the proportion among elderly women over 65 years old is as high as 51%. [5] . OAB seriously aff...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K31/352C07D311/30C07D311/40A61P13/10
Inventor 张俊清陈峰谭银丰徐鹏李洪福
Owner HAINAN MEDICAL COLLEGE
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