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Delivery of a selectively replicating herpes simplex viral vector to the brain by convection- enhanced delivery (CED)

A virus carrier and carrier technology, applied in the direction of virus/bacteriophage, double-stranded DNA virus, virus, etc., can solve the problems of no systematic evaluation and optimization

Inactive Publication Date: 2013-09-25
RENISHAW PLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Given this large body of research, it is surprising that no attempt has been made to systematically evaluate and optimize the delivery of these vectors directly into the brain

Method used

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  • Delivery of a selectively replicating herpes simplex viral vector to the brain by convection- enhanced delivery (CED)
  • Delivery of a selectively replicating herpes simplex viral vector to the brain by convection- enhanced delivery (CED)
  • Delivery of a selectively replicating herpes simplex viral vector to the brain by convection- enhanced delivery (CED)

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Embodiment Construction

[0053] preamble

[0054] Malignant gliomas are the most common primary brain tumors and are almost always incurable. Key reasons for this include the highly invasive nature of these tumors, their inherent chemoresistance, and the difficulty associated with achieving therapeutic concentrations of chemotherapy in the brain without causing toxicity. Direct intraparenchymal administration of oncolytic viral vectors using convection-enhanced delivery is a promising new therapeutic strategy. But there is no evidence that an oncolytic virus as large as HSV-1 can be administered by CED. In this study, the ability to administer HSV-1 viral vectors in the gray and white matter of small (rat) and large (pig) animal models was evaluated in detail.

[0055] HSV-1-based vectors expressing the EGFP reporter gene were infused into the striatum and corpus callosum of rats and the corona radiata of pigs using infusion parameters compatible with CED. Use stereological methods to determine the...

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Abstract

The invention relates to a composition comprising albumin and a therapeutic agent, particularly a gene therapy vector. The composition is useful in the treatment of glioma.

Description

technical field [0001] The present invention relates to compositions and compounds useful in the treatment of glioma. Background technique [0002] Malignant gliomas are the most common primary brain tumors and are associated with a very poor prognosis (Wrensch et al., 2002). Gliomas are postulated to arise from endogenous glial progenitors or neural stem cells (Canoll and Goldman, 2008), with which they share The ability to shift the whiter matter tract and the perivascular and subpial spaces (Louis, 2006). Therefore, malignant gliomas are highly invasive tumors, and their complete resection by surgery is not feasible. The observation that 80% of malignant gliomas recur within 2 cm to 3 cm of the initial tumor mass has raised serious concerns about the limitations of conventional treatment modalities where adequately treating infiltrating tumor cells (Hess et al., 1194). [0003] Herpes simplex virus (HSV-1) is a large naturally occurring neurotropic double-stranded DNA ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/765C12N15/869C12N15/87C12N15/86A61K48/00
CPCA61K48/0008A61K48/0075C07K14/765C12N15/86C12N2710/16643C12N2710/16632A61K48/0083A61P35/00C12N15/87
Inventor 爱德华·怀特史蒂文·斯特里特菲尔德·吉尔
Owner RENISHAW PLC
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