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Application of nymphaea hybrid extract in preparing drugs for treatment of gout, hyperuricemia and uric acid nephropathy and preparation method of nymphaea hybrid extract

A technology for hyperuricemia and uric acid nephropathy, which is applied to drugs for hyperuricemia and uric acid nephropathy. In the field of preparation and treatment of gout, the water extract of perfume lotus can solve problems such as large toxic and side effects.

Inactive Publication Date: 2013-11-20
NANJING WILD PANT COMPREHENSIVE UTILIZATION INST THE ALL CHINA SUPPLY & MARKETING COOPERATIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, it was considered to be suitable for patients with decreased renal function, but in recent years, the serious toxic and side effects have been more deeply understood, which limits its application in the remission period of ventilation
[0007] Non-steroidal anti-inflammatory drugs, such as indomethacin and Voltaren, can also cause serious adverse reactions, such as gastrointestinal bleeding, aplastic anemia, liver and kidney dysfunction, etc., with relatively large toxic and side effects

Method used

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  • Application of nymphaea hybrid extract in preparing drugs for treatment of gout, hyperuricemia and uric acid nephropathy and preparation method of nymphaea hybrid extract
  • Application of nymphaea hybrid extract in preparing drugs for treatment of gout, hyperuricemia and uric acid nephropathy and preparation method of nymphaea hybrid extract
  • Application of nymphaea hybrid extract in preparing drugs for treatment of gout, hyperuricemia and uric acid nephropathy and preparation method of nymphaea hybrid extract

Examples

Experimental program
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Effect test

Embodiment 1

[0018] The preparation of the ovary aqueous extract of embodiment 1 perfume lotus (Nymphaea hybrid) band stamen

[0019] Take 500g of the dried ovary of Nymphaea hybrid with stamens, put it into a 10000mL round bottom flask, add 6000mL of distilled water, heat and reflux for extraction for 3 hours, and filter while hot to obtain the filtrate; add 4000mL of distilled water to heat and reflux for extraction for 2 hours , filtered while hot to obtain the filtrate; the combined filtrates were concentrated under reduced pressure to remove water to obtain 248g of the water extract of the ovary of the lotus flower with stamens.

Embodiment 2

[0020] The preparation of the ovary aqueous extract of embodiment 2 perfume lotus (Nymphaea hybrid) band stamen

[0021] Take 500g of the dried ovary with stamens of Nymphaea hybrid, put it into a 10000mL round bottom flask, add 6000mL of distilled water, heat and reflux for extraction for 3 hours, and filter while it is hot to obtain the filtrate; the filtrate is concentrated under reduced pressure to remove water to obtain the perfume Water extract of ovary of lotus with stamens 179g.

Embodiment 3

[0022] The preparation of the ovary water extract of embodiment 3 perfume lotus (Nymphaea hybrid) band stamen

[0023] Take 500g of the dried ovary with stamens of Nymphaea hybrid, put it into a 10000mL round bottom flask, add 6000mL of distilled water, heat and reflux for extraction for 2 hours, and filter while hot to obtain the filtrate; add 4000mL of distilled water to heat and reflux for extraction for 2 hours , filtered while hot to obtain the filtrate; the medicinal dregs were added with 4000mL of distilled water and heated and refluxed for extraction for 2 hours, filtered while hot to obtain the filtrate; the combined filtrates were concentrated under reduced pressure to remove water to obtain 295g of the ovary water extract of Perfume Lotus with stamens.

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Abstract

The invention relates to medical new application and a preparation method of a nymphaea hybrid extract. Studies of the invention show that: the nymphaea hybrid aqueous extract can effectively reduce the blood serum blood uric acid level in a mice hyperuricemia model, one of the mechanisms of the the nymphaea hybrid aqueous extract is that: through inhibition of in-vivo xanthine oxidase activity, the formation of uric acid is inhibited and uric acid excretion is promoted. Hyperuricemia damages physiological functions of the kidney with increasing of urea nitrogen concentration being shown, and the nymphaea hybrid aqueous extract can reduce the blood uric acid, reduce stimulation of the uric acid on the kidney, and has a therapeutic effect on uric acid nephropathy. Therefore, the nymphaea hybrid aqueous extract can be used for preparing drugs for the treatment of gout, the hyperuricemia and the uric acid nephropathy.

Description

technical field [0001] The invention relates to a new application of the perfumed lotus extract in medicine, in particular to a new application of the perfumed lotus water extract in preparing medicines for treating gout, hyperuricemia and uric acid nephropathy. Background technique [0002] Gout is a disease caused by chronic purine metabolism disorder in the body, mainly due to pathophysiological changes caused by increased uric acid production and / or decreased uric acid excretion and uric acid deposition in the body. Gout is manifested as hyperuricemia, recurrent gouty acute arthritis, tophi, uric acid nephropathy, often accompanied by urinary calculi, and severe joint deformities and dysfunction. Only hyperuricemia, or hyperuricemia combined with uric acid nephrolithiasis, is not yet defined as gout. At present, the prevalence of gout in my country is 0.84% ​​in the general population, about 12 million people; 95% of them are male patients; the ratio of male to female i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/62A61P19/06A61P13/12
Inventor 张卫明单承莺姜洪芳
Owner NANJING WILD PANT COMPREHENSIVE UTILIZATION INST THE ALL CHINA SUPPLY & MARKETING COOPERATIV
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