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Application of Japanese ginseng or extract thereof to preparation of medicament for resisting gout and repairing hyperuricemic kidney injury

A technology of bamboo ginseng and extract, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., and can solve the problems of relapse and aggravation, "rebound, lack of drugs and treatment methods, etc.

Active Publication Date: 2012-11-28
石杨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although colchicine can quickly relieve symptoms, it has no effect on reducing blood uric acid, and has relatively large side effects, strong gastrointestinal reactions, damage to liver, kidney function and hematopoietic system, and some people think it can cause cancer
[0009] 2. Non-steroidal anti-inflammatory drugs such as indomethacin and Voltaren can also cause serious adverse reactions, such as gastrointestinal bleeding, aplastic anemia, liver and kidney dysfunction, etc., with relatively large side effects
[0010] 3. Glucocorticoids can quickly relieve acute attacks, but often appear "rebound" phenomenon (relapse and exacerbation) after drug withdrawal, and can prolong the course of the disease, so generally it can only be used when colchicine and non-steroidal anti-inflammatory drugs are ineffective
In the past, it was considered to be suitable for gout patients with decreased renal function, but in recent years, the serious side effects have been more deeply understood, which limits its application in the remission period of gout
[0014] To sum up, in the treatment of hyperuricemia and gout in modern medicine, due to the serious side effects of the main drugs used, there are often large treatment contradictions in clinical use. Different scholars have different opinions on the selection and use of drugs. There are often different views, especially the treatment of gout patients with renal dysfunction is quite difficult, and there is still a lack of ideal drugs and treatment methods

Method used

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  • Application of Japanese ginseng or extract thereof to preparation of medicament for resisting gout and repairing hyperuricemic kidney injury
  • Application of Japanese ginseng or extract thereof to preparation of medicament for resisting gout and repairing hyperuricemic kidney injury
  • Application of Japanese ginseng or extract thereof to preparation of medicament for resisting gout and repairing hyperuricemic kidney injury

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Preparation of Panax ginseng saponin v and Panax ginseng total saponins

[0030]Preparation of total saponins of Panax ginseng: Take 200 grams of Panax ginseng coarse particles, put them in a 3000ml round bottom flask, add 60% ethanol of 10 times the amount of Panax ginseng coarse powder, soak for 2 hours, and extract by reflux in a water bath for 2 hours , filtered to obtain the filtrate. The dregs were then reflux extracted twice with 10 times the amount of 60% ethanol, each time for 2 hours, and filtered. Combine the filtrates for 3 times, recover the ethanol under reduced pressure until there is no alcohol smell, and prepare medicinal materials: the aqueous solution (g / ml) of 0.5:1 is put on the HPD-100 macroporous resin column that has been treated, and then water, 60% The ethanol was eluted, the water eluate was discarded, the 60% ethanol eluate was combined, the solvent was recovered to nearly dryness, and dried under reduced pressure at 65°C to obtain about 15 ...

Embodiment 2

[0033] Determination of Saponin v and Total Saponins of Panax ginseng

[0034] 1. Chromatographic conditions

[0035] SPD-20A high-performance liquid chromatography, the chromatographic column is Boston analytics, Green ODS-AQ 4.6×150mm 5um, the wavelength is 203nm, the injection volume is 20ul, the flow rate is 1.0ml / min, the column temperature is 25°C, and the mobile phase is Acetonitrile (A): 10mM phosphate buffered aqueous solution (B) (weigh KH 2 PO 4 Drug 0.68g, add 500ml purified water, use K 2 HPO 4 Adjust the pH to 5.8, mix well, filter through a 0.45um microporous membrane, and sonicate for 10-15 minutes to obtain) gradient elution (elution gradient: 0-19 minutes, A:B=27:73; 20-33 minutes, A:B=28:72; 34-43 minutes, A:B=34:66; 44-57 minutes, A:B=43:57; 57.5-64 minutes, A:B=85: 15; 65-80 minutes, A:B=27:73).

[0036] 2. Preparation of the reference substance bamboo ginseng saponin v (also known as ginsenoside Ro, which can be referred to as Ro) solution: take an ...

Embodiment 3

[0045] Experimental study on the anti-gout effects of total saponins of Panax ginseng, saponins v of Panax ginseng, water extract of Panax ginseng, ethanol extract of Panax ginseng, methanol extract of Panax ginseng and medicinal powder of Panax ginseng

[0046] 1. Experimental materials: Tongfengding capsule (Chengdu Zhongjiang Pharmaceutical Co., Ltd. batch number 090104), potassium oxonate (Nanjing Jiancheng Biotechnology Co., Ltd., batch number: 090204), xanthine (sigma), uric acid assay kit (Nanjing Jiancheng Biotechnology Co., Ltd. Co., Ltd., batch number 20090420), Coomassie brilliant blue protein assay kit (Nanjing Jiancheng Biotechnology Co., Ltd., batch number 20090325) xanthine oxidase assay kit (Nanjing Jiancheng Biotechnology Co., Ltd., batch number 20090514), ethambutol hydrochloride ( Hangzhou Minsheng Pharmaceutical Group Co., Ltd., batch number T09L542), uric acid assay kit (Nanjing Jiancheng Biotechnology Co., Ltd., batch number 20091120), creatinine assay kit...

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Abstract

The invention discloses application of Japanese ginseng or extract thereof which serves as an active ingredient to preparation of a medicament for resisting gout and repairing hyperuricemic kidney injury. Researches show that the uric acid lowering effect of the Japanese ginseng or the extract thereof is mainly realized by repairing the hyperuricemic kidney injury and increasing the renal displacement of uric acid.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to the application of bamboo ginseng or its extract in the preparation of medicines for resisting gout and / or repairing hyperuric acid kidney damage. Background technique [0002] Gout is a metabolic disease caused by purine metabolism disorder leading to increased uric acid production and / or decreased uric acid excretion. Its clinical features are hyperuricemia; recurrent acute and chronic arthritis and soft tissue injury caused by urate deposition; gouty kidney injury caused by uric acid kidney stones. When the serum uric acid value is ≥416umol / L (7.0mg / dl), it becomes hyperuricemia. Hyperuricemia (high-dose hyperuricimia) is the premise and biochemical basis of gout, and gout must be accompanied by hyperuricemia; but the prevalence of gout is much lower than hyperuricemia, because the excretion of uric acid in urine increases, It can reduce the occurrence...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P13/12A61P19/06
Inventor 石杨
Owner 石杨
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