Application of compound in preparation of medicines for preventing and treating liver injury
A liver injury and compound technology, which is applied to the application field of compounds in the preparation of drugs for preventing and treating liver injury, can solve problems such as liver damage, aggravation, and elevation, and achieve the effect of strong therapeutic activity and outstanding substantive characteristics.
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Embodiment 1
[0011] Embodiment 1: the preparation of the compound Aphanamgrandiol A tablet involved in the present invention:
[0012] Take 5 grams of compound Aphanamgrandiol A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.
Embodiment 2
[0013] Embodiment 2: the preparation of compound Aphanamgrandiol A capsules involved in the present invention:
[0014] Get 5 grams of compound Aphanamgrandiol A, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules.
[0015] The following pharmacodynamic experiments will further illustrate its drug activity.
experiment example 1
[0016] Experimental example 1. The effect of Aphanamgrandiol A on preventing and treating liver injury
[0017] (1) Protective effect of Aphanamgrandiol A on D-galactosamine (D-GalN)-induced acute liver injury in mice
[0018] The mice were divided into 5 groups. The control group was given intragastric administration of normal saline (0.3mL·d-1) for 7 consecutive days. , 6.0mg·kg-1) Each group was given intragastric administration of normal saline and different concentrations of Aphanamgrandiol A (0.3mL·d-1) for 7 consecutive days, and intraperitoneally injected D-GalN (800mg·kg-1, 0.15 mL·10g-1), blood was collected after 16 hours, and AST and ALT activities were measured.
[0019] Table 1 Protective effect of Aphanamgrandiol A on acute liver injury induced by D-GalN
[0020]
[0021] Note: * p<0.01vs control group, #p<0.01vs D-GalN group
[0022] It can be seen from Table 1 that Aphanamgrandiol A can effectively inhibit the significant increase of AST and ALT activit...
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