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Application of compound in preparation of medicines for preventing and treating liver injury

A liver injury and compound technology, which is applied to the application field of compounds in the preparation of drugs for preventing and treating liver injury, can solve problems such as liver damage, aggravation, and elevation, and achieve the effect of strong therapeutic activity and outstanding substantive characteristics.

Inactive Publication Date: 2013-11-27
HUAIAN UNIV SCI PARK MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intravenous nutrition, etc., can all cause liver damage to varying degrees. The early manifestations of these liver damage are often Elevation of ALT (transaminase) or bilirubin, if the cause is not eliminated, the liver damage will be further aggravated

Method used

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  • Application of compound in preparation of medicines for preventing and treating liver injury
  • Application of compound in preparation of medicines for preventing and treating liver injury
  • Application of compound in preparation of medicines for preventing and treating liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of the compound Aphanamgrandiol A tablet involved in the present invention:

[0012] Take 5 grams of compound Aphanamgrandiol A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Aphanamgrandiol A capsules involved in the present invention:

[0014] Get 5 grams of compound Aphanamgrandiol A, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0016] Experimental example 1. The effect of Aphanamgrandiol A on preventing and treating liver injury

[0017] (1) Protective effect of Aphanamgrandiol A on D-galactosamine (D-GalN)-induced acute liver injury in mice

[0018] The mice were divided into 5 groups. The control group was given intragastric administration of normal saline (0.3mL·d-1) for 7 consecutive days. , 6.0mg·kg-1) Each group was given intragastric administration of normal saline and different concentrations of Aphanamgrandiol A (0.3mL·d-1) for 7 consecutive days, and intraperitoneally injected D-GalN (800mg·kg-1, 0.15 mL·10g-1), blood was collected after 16 hours, and AST and ALT activities were measured.

[0019] Table 1 Protective effect of Aphanamgrandiol A on acute liver injury induced by D-GalN

[0020]

[0021] Note: * p<0.01vs control group, #p<0.01vs D-GalN group

[0022] It can be seen from Table 1 that Aphanamgrandiol A can effectively inhibit the significant increase of AST and ALT activit...

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Abstract

The invention conducts a pharmacological study to Aphanamgrandiol A and discovers that the Aphanamgrandiol A has the protective effect on D-galactosamine (D-Ga1N)-induced acute liver injury of mice and CC14-induced acute liver injury of mice. Therefore, the Aphanamgrandiol A can be used to prepare medicines for preventing and treating liver injury or liver injury. An application of the Aphanamgrandiol A in preparation of medicines for preventing and treating liver injury provided by the invention is disclosed for the first time. As the framework type of the Aphanamgrandiol A is a novel framework type, and the activity of the Aphanamgrandiol A to therapeutical effect of liver injury is unexpectedly strong, the probability of giving any indication by other compounds does not exist. The Aphanamgrandiol A has remarkable substantive characteristics and meanwhile has a remarkable progress for treating liver injury.

Description

technical field [0001] The present invention relates to a new application of compound Aphanamgrandiol A, in particular to the application of Aphanamgrandiol A in the preparation of drugs for preventing and treating liver damage. Background technique [0002] There are multiple reasons for causing liver damage: 1. Viral infection: caused by a variety of hepatitis viruses, with strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. 2. Drugs or chemical poisons: Many drugs and chemical poisons can cause liver damage, drug-induced hepatitis or toxic hepatitis. 3. Alcoholism: Alcohol damages the liver very seriously. The consequences of the damage include alcoholic hepatitis, alcoholic fatty liver, and alcoholic cirrhosis, mainly due to the toxicity of alcohol (ethanol) and its metabolite acetaldehyde on liver cells. caused by direct damage. 4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insuffici...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P1/16
Inventor 张康
Owner HUAIAN UNIV SCI PARK MANAGEMENT CO LTD
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