A kind of preparation method of silver ion hydrogel dressing

A technology of silver ionized water and hydrogel, applied in medical science, bandages, absorbent pads, etc., can solve the problems of limited use range, pigment deposition on wound surface, low silver utilization rate, etc., to promote wound healing and biocompatibility. The effect of sexual enhancement, inhibition and prevention of growth

Active Publication Date: 2015-11-04
长春吉原生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional wound care products with silver as the active ingredient, represented by silver sulfadiazine, have a very low utilization rate of silver. In order to ensure the therapeutic effect, a large dose of silver needs to be added, which causes waste of resources and promotes pigmentation on the wound surface. , silver poisoning and other negative effects
Recently, products made by spraying silver on support materials such as gauze and alginate fibers have appeared. These products replace the silver components in the products with body fluids exuded from the wound to achieve antibacterial effects, but such dry dressings only Applicable to wounds with exudate, the scope of use is limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Put 30g of polyvinylpyrrolidone, 20g of polyvinyl alcohol and 950g of water into a reaction kettle that can be heated, stirred and vacuum degassed, heat up and stir until completely dissolved, and then drop the feed liquid to room temperature to obtain a hydrophilic polymer polymer aqueous solution; the obtained hydrophilic polymer aqueous solution is coated on the backing material (in this embodiment, a medical non-woven fabric) by coating equipment, and the upper surface is covered with a release film to obtain a semi-finished hydrogel material; Carry out the high-energy ray radiation of 10kgy by the hydrogel material semi-finished product that makes by cobalt 60 radioactive source, make hydrogel material; The hydrogel material is immersed in the silver nitrate solution that silver ion concentration is 0.001% by weight, Make the heavy silver ion content of the hydrogel material reach 0.0001%, and prepare the silver ion hydrogel dressing.

Embodiment 2

[0022] Put 15g of polyvinyl alcohol and 85g of water into a reaction kettle capable of heating, stirring and vacuum defoaming, heat up and stir until completely dissolved, and drop the feed liquid to room temperature to obtain a hydrophilic polymer aqueous solution; the prepared hydrophilic The water-based polymer aqueous solution is injected into the mold, and the upper surface is covered with a release film to obtain a semi-finished hydrogel material; the semi-finished hydrogel material is irradiated with a dose of 30kgy high-energy rays through a cobalt 60 radiation source to produce A hydrogel material is obtained; the hydrogel material is immersed in a silver nitrate solution with a silver ion concentration of 0.05% by weight, so that the heavy silver ion content of the hydrogel material reaches 0.005%, and a silver ion hydrogel dressing is obtained.

Embodiment 3

[0024] Put 15g of polyvinyl alcohol, 15g of polyacrylamide and 70g of water into a reaction kettle that can be heated, stirred and vacuum degassed, heat up and stir until completely dissolved, and then drop the feed solution to room temperature to obtain a hydrophilic polymer Polymer aqueous solution; the prepared hydrophilic polymer aqueous solution is injected into the mold, and the upper surface is covered with a release film to obtain a semi-finished hydrogel material; the semi-finished hydrogel material is dosed through a cobalt-60 radioactive source The high-energy ray radiation of 30kgy makes the hydrogel material; the hydrogel material is immersed in the silver nitrate solution with a silver ion concentration of 0.05% by weight, so that the heavy silver ion content of the hydrogel material reaches 0.003%, and the silver nitrate is obtained. Ionic hydrogel dressing.

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PUM

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Abstract

The invention relates to a preparation method of silver ion hydrogel dressing. The method comprises the following steps: firstly, a hydrophilic high-molecular polymer aqueous solution is prepared, and is subjected to vacuum defoamation for standby; secondly, the hydrophilic high-molecular polymer aqueous solution obtained in the first step is prepared into a hydrogel material semi-finished product through a coating method or an injection molding method; thirdly, the hydrogel material semi-finished product is prepared into hydrogel material through the radiation of high energy ray; fourthly, the hydrogel material is dipped into silver salt aqueous solution, so that the hydrogel material absorbs silver ion loaded in the silver salt aqueous solution, and then the silver ion hydrogel dressing is obtained. The prepare silver ion hydrogel dressing prepared through the method has good biocompatibility, is non-irritative and non-sensitized to skin, provides wet healing environment for wound healing, promotes wound healing, moreover can slowly release silver ion, effectively restrains and prevents the growth of common bacteria on the wound, and can be applied to nursing of various acute and chronic wounds.

Description

technical field [0001] The invention relates to the technical field of dressing preparation, in particular to a preparation method of a silver ion hydrogel dressing. Background technique [0002] Traditional dressings represented by gauze bandages are currently the most widely used dressings in trauma clinics. Their strong ability to absorb wound exudate has a certain protective effect on wounds and can prevent exudate accumulation. The wound surface will adhere to the wound surface, which will cause secondary damage to the wound surface when changing the dressing, and slow down the wound healing speed. With the introduction of the theory of moist healing, a new generation of dressings that can provide a moist healing environment such as alginate, hydrocolloid, and hydrogel have significant therapeutic and nursing effects, and are widely recognized and widely used. [0003] Hydrogel is a polymer compound with a three-dimensional network structure, which can absorb and slowl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/26A61L15/28A61L15/18A61L15/42A61L15/44
Inventor 赵彬王靖哲余航于春暖王栗周德根王秀梅
Owner 长春吉原生物科技有限公司
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