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Collision reaction tank

A collision reaction cell and collision reaction technology, applied in dynamic spectrometers, trajectory-stabilized spectrometers, mass spectrometers, etc., can solve the problems of great influence, reducing the reaction efficiency of target interfering ions, and inability to use the mass-shift method. Effective mass filtering, the effect of removing chemical background

Inactive Publication Date: 2014-04-09
FOCUSED PHOTONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] (1) When the collision reaction cell works in the reaction mode, it is required to feed a specific reaction gas, and the collision reaction cell is maintained at a relatively high pressure condition, and the quadrupole cannot achieve good mass resolution under this pressure condition. Therefore, the accuracy of mass discrimination is not high; similarly, the mass discrimination accuracy of the low mass cut-off characteristic of the square quadrupole is also affected by the pressure condition and decreases
(2) A large number of parent ions enter the collision reaction cell with mass screening, and ion-molecule reactions may occur before being rejected. On the one hand, new interfering ions are generated, and on the other hand, the reaction efficiency of target interfering ions is also reduced.
(3) The ion composition in the collision reaction cell is greatly affected by the background ions of the sample, and it cannot maintain a simple and consistent reaction under various complex matrix conditions
(4) When there are interference ions of the mass-shift method target ion in the background ion, the mass-shift method cannot be used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A collision reaction cell, the collision reaction cell includes two electrode groups, each electrode group includes two pairs of electrodes, the two pairs of electrodes are placed orthogonally, wherein the two electrodes of each pair of electrodes are arranged oppositely; each electrode group A collision reaction zone is formed between two pairs of electrodes, and a reverse RF voltage of the same frequency is applied between two adjacent electrodes of each electrode group; the collision reaction gas passes into the second electrode group.

[0029] Preferably, a reverse RF voltage of the same amplitude and frequency is applied between two adjacent electrodes of each electrode group.

[0030] The first electrode group maintains low pressure, does not pass through the collision reaction gas, and performs pre-mass filtration; the second electrode group has the ability to discriminate mass, and passes through the collision reaction gas.

[0031] Further, the two electrode gr...

Embodiment 2

[0044] This embodiment is an application example of Embodiment 1.

[0045]In this embodiment, the two electrode groups are composed of flat electrodes (or square quadrupole rods), and a certain RF voltage is applied to generate an approximate quadrupole field in the central area, and the ability of quality discrimination is obtained by using the low mass cut-off characteristic . Antiphase RF voltages are applied to the electrodes corresponding to the two electrode groups.

[0046] The RF voltages on the two stages are applied separately, and the amplitudes are RF1 and RF2 respectively, which are determined by the requirements of mass filtering.

[0047] Since the first-stage vacuum pressure is low, it can provide better mass resolution, so the RF voltage setting of the first electrode group is higher than that of the second electrode group to achieve higher-precision mass filtration.

Embodiment 3

[0049] A kind of collision reaction cell, different from the collision reaction cell described in embodiment 2 is:

[0050] An AC voltage is applied to the first electrode group to selectively filter out parent ions and other interfering ions according to the characteristics of ion resonance excitation.

[0051] In this way, if there is an interfering ion of the target ion of the mass-shift method, the interfering ion can be eliminated by applying an AC signal with a specific frequency component, so the mass-shift method can still be used in this situation.

[0052] Analyze Se, because there are pairs of 80 Se + analyzed because there is a strong 40 Ar 40 Ar + Ion signals cannot be analyzed directly. Introducing O2 into the collision reaction cell, the ion-analysis reaction will 80 Se + transform into 80 Se 16 o + Indirect measurement, this is the so-called mass-shift method. However, if the sample also contains 96 Zr + , 96 Mo + When plasma, it will 80 Se 16 ...

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Abstract

The invention relates to a collision reaction tank. The collision reaction tank comprises two electrode assemblies, wherein each electrode assembly comprises two pairs of electrodes, the corresponding two pairs of the electrodes are arranged in an orthogonal mode, and the two electrodes of each pair of the electrodes are arranged oppositely. A collision reaction region is formed between the two pairs of the electrodes of the corresponding electrode assembly, and same-frequency reverse RF voltages are applied between two adjacent electrodes of the corresponding electrode assembly. Collision reaction gas is fed to the other electrode assembly. The collision reaction tank has the advantages that mass filter accuracy is high, and working conditions of the collision reaction tank can be simplified.

Description

technical field [0001] The invention relates to a collision reaction pool. Background technique [0002] Interference in ICP-MS can be divided into two categories: "mass spectral interference" and "non-mass spectral interference" or "matrix effect". The first type of interference can be further divided into four types: ① isobaric overlap interference; ② polyatomic ion interference; ③ refractory oxide interference; ④ doubly charged ion interference. The second type of interference can be broadly divided into ① suppression and enhancement effects ② physical effects caused by high salt content. [0003] Collision / reaction cell system (CRC) has three main working principles or modes, namely interference ion collision dissociation mode (collisional induced dissociation, CID), reaction mode (reaction), interference ion function discrimination elimination mode (kinetic energy discrimination, KED) . [0004] In the reaction mode, the products produced by the reaction of ions and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/42
Inventor 梁炎陈斌杨凯刘立鹏郑毅韩双来邱明徐岳陈飞华陈文益李鹰
Owner FOCUSED PHOTONICS
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