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Application of trigoxyphin K in the treatment of rhinitis

A drug and rhinitis technology, applied in the application field of Trigoxyphin K in the treatment of rhinitis drugs, can solve the problems of ineffectiveness and poor curative effect of rhinitis

Active Publication Date: 2016-05-18
南京易亨制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used in the treatment of rhinitis. These drugs have poor or ineffective effects on chronicity and recurrent rhinitis

Method used

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  • Application of trigoxyphin K in the treatment of rhinitis
  • Application of trigoxyphin K in the treatment of rhinitis
  • Application of trigoxyphin K in the treatment of rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of the compound TrigoxyphinK tablet involved in the present invention:

[0014] Take 5 grams of compound TrigoxyphinK, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0015] Embodiment 2: the preparation of the compound TrigoxyphinK capsule involved in the present invention:

[0016] Take 5 grams of the compound TrigoxyphinK, add 195 grams of starch, mix well, and make 1000 capsules.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0018] Experimental example 1, the influence of TrigoxyphinK of the present invention on ovalbumin-induced allergic rhinitis in rats

[0019] Male SD rats, weighing 180-220 g, were injected intraperitoneally with 1 mg of ovalbumin and 10 mg of aluminum hydroxide gel at the Experimental Animal Center of Nanjing Medical University, and then once every other day, for a total of 7 times. From the 14th day, 10ul of 1mg / ml ovalbumin physiological saline solution was instilled into the nasal cavities of both sides of the rat every day, 7 times in total. Immediately after the last infusion, observe the number of times the rats sneeze and wipe their noses within 30 minutes, and the test drug is orally administered 1 hour before the last infusion of ovalbumin.

[0020] Table 1 The effect of TrigoxyphinK of the present invention on ovalbumin-induced allergic rhinitis in rats (x±SD)

[0021]

[0022]

[0023] Compared with the control group, **P<0.01*P<0.05

[0024] It can be seen...

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PUM

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Abstract

Trigoxyphin K for treating immune inflammation is used for preparation of immune-inflammation treatment drugs, and is especially suitable for preparation of rhinitis treatment drugs; with terfenadine and diclofenac sodium as controls, the Trigoxyphin K is clear in curative effect. The Trigoxyphin K application in preparation of the rhinitis treatment drugs is initially public, because the skeleton type belongs to a new skeleton type, and the rhinitis treatment activity is strong, the Trigoxyphin K has prominent substantive features, and at the same time obviously has significant progresses in application in rhinitis prevention and treatment.

Description

technical field [0001] The present invention relates to a new application of the compound TrigoxyphinK, in particular to the application of TrigoxyphinK in preparing a medicine for treating rhinitis. Background technique [0002] Rhinitis is a common and frequently-occurring disease in clinical practice. The occurrence of rhinitis is mainly related to allergic reactions and belongs to the category of immune inflammation. At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used for the treatment of rhinitis, and these drugs have poor or ineffective effects on chronicity and recurrent rhinitis. Therefore, small molecular compounds with clear components, quality control, safety and high efficiency have potential value in the development of drugs for rhinitis treatment. [0003] The compound TrigoxyphinK involved in the present invention is a new compound published in 2013 (BiaoYang, et al., Fivenewdegradedditerpe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P11/02
Inventor 田丽华
Owner 南京易亨制药有限公司
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