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Application of Lorcaserin hydrochloride in preparation of medicine for inhibiting opioid addiction and withdrawal syndrome

A technology of lorcaserin hydrochloride and opioids, which is applied in the drug field of addiction and withdrawal behavior, and can solve the problems of psychological dependence and unsatisfactory curative effect

Inactive Publication Date: 2014-06-25
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of narcotics to deprive consciousness so that addicts can go through the withdrawal period without pain is also a treatment method. However, these drugs and methods can only treat symptoms and temporarily relieve the withdrawal symptoms caused by nerve excitation such as NE and Ach energy.
[0013] Most of the above-mentioned treatment methods can better solve the physical dependence caused by addiction, but they are not satisfied with the curative effect on psychological dependence. Therefore, it is urgent to find a treatment that can better solve psychological dependence and reduce the relapse rate

Method used

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  • Application of Lorcaserin hydrochloride in preparation of medicine for inhibiting opioid addiction and withdrawal syndrome
  • Application of Lorcaserin hydrochloride in preparation of medicine for inhibiting opioid addiction and withdrawal syndrome
  • Application of Lorcaserin hydrochloride in preparation of medicine for inhibiting opioid addiction and withdrawal syndrome

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Embodiment Construction

[0034] In order to better understand the essence of the present invention, the experimental results of lorcaserin hydrochloride antagonizing morphine addiction will be used below to illustrate its medicinal value in opioid addiction and withdrawal.

[0035] 1 Research Methods

[0036] 1.1 Experimental animals - 50 SPF-grade Kunming mice, half male and half female, weighing 18-22g, were purchased from the Provincial Experimental Animal Center of Anhui Medical University, production license number: SCXK (Anhui) 2011-002. Experimental animal use license number: SYXK (Anhui) 2011-007. Breeding room temperature: 22±2°C; humidity: 40-70%; lighting cycle: 12h light / 12h dark.

[0037] 1.2 Drugs and reagents - morphine: Shenyang No. 1 Pharmaceutical Factory, batch number: 080301; (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (lorcaserin, lorca hydrochloride Serin): Hebei Pharmaceutical Factory, batch number: 20120902; naloxone: China Medical System (Hunan) Pharmaceutical...

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Abstract

The invention relates to an application of Lorcaserin hydrochloride in preparation of a medicine for inhibiting opioid addiction and withdrawal syndrome. The Lorcaserin hydrochloride is approved to be a weight-reducing aid by the America Food and Drug Administration (FDA) in 2012. The Lorcaserin hydrochloride is a 5-hydroxytryptamine 5-HT2C receptor stimulant with high selectivity. The latest research of the invention finds that the Lorcaserin hydrochloride (0.5-1.0mg.kg<-1>) greatly reduces the naloxone-urged horizontal motion distance and speed of a morphine dependent mice and the withdrawal syndrome of the mice. It is found in the invention for the first time that the Lorcaserin hydrochloride can be applied clinically for rescuing and treating addiction and withdrawal syndrome generated by morphine and other opiates.

Description

technical field [0001] The invention belongs to the field of drugs for treating the addiction and withdrawal behavior of morphine and other opioid substances, and specifically relates to a new application of a clinical medicine for treating the addiction and withdrawal behavior of morphine and other opioid substances. Background technique [0002] Hazards and Mechanisms of Opioid Addiction [0003] The abuse and addiction of the opioid morphine and its chemically synthesized derivative heroin have become medical and social problems of global concern. Opioids and drug abuse have become a growing social problem in our country and many other countries, especially in Southwest Asia, Central Asia, Southeastern Europe and North America (World Drug Report 2013, United Nations Office on Drugs and Crime). Drug users in China mainly abuse heroin and other opioids. By the end of 2012, there were 2.098 million registered drug users nationwide, of which 1.272 million were opioid abusers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61P25/36
Inventor 章功良董六一吴县刘欢江勤
Owner ANHUI MEDICAL UNIV
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