Drug for preventing and treating atherosclerotic plaque by adopting methods for removing wind, expelling phlegm and detoxifying, and preparation method of drug
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An atherosclerosis and plaque technology, which can be used in drug combinations, pharmaceutical formulations, medical raw materials derived from arthropods, etc., can solve the problems of plaque rupture, difficult to control plaque, and large toxic and side effects.
Inactive Publication Date: 2014-07-02
FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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[0010] The rupture of unstable AS plaques is the main cause of cardiovascular events (including myocardial infarction and sudden death), and it is very important to stabilize AS plaques. Currently, the drugs used to stabilize plaques in Western medicine include statins, which have extremely toxic side effe
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Embodiment 1
[0046] Soak 3g of scorpion, 3g of centipede, 13g of earthworm, 14g of leech, 15g of tangerine peel, 14g of pinellia, 13g of atractylodes macrocephala, and 14g of honeysuckle in 15 times the amount of water for 40 minutes. Add 10 times the amount of water and decoct with a slow fire for 50 minutes, add 6 times the amount of water for the third time and decoct with a slow fire for 30 minutes, combine the three decoctions, filter the obtained medicine with gauze, and use 100 ℃ water bath to concentrate to 200ml of liquid medicine, that is, the finished product.
Embodiment 2
[0048] Soak 4g of scorpion, 4g of centipede, 14g of earthworm, 15g of leech, 14g of tangerine peel, 13g of Pinellia 13g, 12g of Atractylodes macrocephala, and 10g of honeysuckle in 15 times the amount of water for 40 minutes. Add 10 times the amount of water and decoct with a slow fire for 50 minutes, add 6 times the amount of water for the third time and decoct with a slow fire for 30 minutes, combine the three decoctions, filter the obtained medicine with gauze, and use 100 ℃ water bath to concentrate to 200ml of liquid medicine, that is, the finished product.
Embodiment 3
[0050] Soak 5g of scorpion, 2g of centipede, 10g of earthworm, 11g of leech, 12g of tangerine peel, 14g of pinellia, 13g of atractylodes macrocephala, and 15g of honeysuckle in 15 times the amount of water for 40 minutes, then boil it for 70 minutes with slow fire for the first time, Add 10 times the amount of water and decoct with a slow fire for 50 minutes, add 6 times the amount of water for the third time and decoct with a slow fire for 30 minutes, combine the three decoctions, filter the obtained medicine with gauze, and use 100 ℃ water bath to concentrate to 200ml of liquid medicine, that is, the finished product.
[0051] An experimental report is made by taking the medicine for preventing and treating atherosclerotic plaque prepared by the above-mentioned embodiment as an example.
[0052] 1 Experimental materials
[0053] 1.1 Experimental animals
[0054] Choose a body weight of 18g ~ 20g, SPF grade 6-8 weeks old ApoE - 70 mice, half male and half male; provider: B...
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Abstract
The invention discloses a drug for preventing and treating atherosclerotic plaque by adopting methods for removing wind, expelling phlegm and detoxifying, and a preparation method of the drug. The product formula comprises the following raw materials by weight: 3-5g of scorpio, 2-4g of centipede, 10-15g of earthworm, 10-15g of leech, 10-15g of pericarpium citri reticulatae, 10-15g of pinellia ternate, 10-15g of bighead atractylodes rhizome and 10-15g of honeysuckle. The preparation method comprises the following steps: soaking the scorpio, the centipede, the earthworm, the leech, the pericarpium citri reticulatae, the pinellia ternate, the bighead atractylodes rhizome and the honeysuckle for 40 minutes by 15-fold water; decocting by a slow fire for 70 minutes for the first time; adding 10fold water to decoct by the slow fire for 50 minutes for the second time; adding 6-fold water to decoct by the slow fire for 30 minutes for the third time; merging the decocted liquors of three times; filtering the obtained liquor by a gauze; concentrating by a water bath at 100 DEG C into 200ml of liquor after filtering, so as to obtain the product. The drug disclosed by the invention is simple in component, accurate in compatibility relationship, few in drugs, low in price, and accurate and significant in curative effect. The animal experiment proves that the drug has significant effects of preventing and treating arteriosclerosis, and adjusting blood fat, and is easily accepted by a sufferer.
Description
technical field [0001] The invention relates to a Chinese herbal medicine in the technical field of medicine, in particular to a medicine for preventing and treating atherosclerotic plaque by searching wind, eliminating phlegm and detoxifying method and a preparation method thereof. Background technique [0002] 1. The relationship between HO-1 and HSP70 and atherosclerosis [0003] Ross clearly stated that "atherosclerosis is an inflammatory disease" based on his damage response theory in 1999, pointing out that atherosclerosis has a pathological process characterized by chronic inflammatory response. A large number of inflammatory mediators and various inflammatory cells are always involved in the formation, rupture and thrombosis of lipid streaks to fibrous plaques and atheromatous plaques, and even unstable plaques, such as heme oxidase 1, heat shock protein, Adhesion factors, macrophages are all involved in the composition of atherosclerotic plaque or blood vessel wall...
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