The invention relates to a
medicine for preventing and treating
intimal hyperplasia after damage of endarterium and a preparation method thereof in the technical field of medicines. A formula of the
medicine for preventing and treating the
intimal hyperplasia after damage of endarterium comprises
rheum officinale,
cassia twig, salviae miltiorrhizae, szechwan lovage
rhizome,
earthworm and
honeysuckle. The preparation method of the
medicine for preventing and treating the
intimal hyperplasia after damage of endarterium comprises the following steps: soaking
rheum officinale,
cassia twig, salviae miltiorrhizae, szechwan lovage
rhizome,
earthworm and
honeysuckle for 40 minutes with 15 times amount of water, decocting with a strong fire for 70 minutes for the first time, adding 10 times amount of water and decocting with a
slow fire for 50 minutes for the second time, adding 6 times amount of water and decocting with a
slow fire for 30 minutes for the third time, putting the decocted liquid medicines together, filtering with a gauze, concentrating to 150ml through water bath at the temperature of 100 DEG C, and storing in a refrigerator at the temperature of 4 DEG C. The medicine for preventing and treating the intimal
hyperplasia after damage of endarterium has the advantages of simple composition, clear compatibility, less
drug flavour, low cost and definite and obvious
curative effect, and animal experiments prove that the medicine for preventing and treating the intimal
hyperplasia after damage of endarterium has the effects of inhibiting
platelet aggregation, inhibiting expression of PDGF-B, obviously preventing and treating the intimal
hyperplasia after damage of endarterium and preventing
restenosis after
percutaneous coronary intervention, so that the medicine for preventing and treating the intimal hyperplasia after damage of endarterium can be easily accepted by a patient.