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Pharmaceutical composition for treating idiopathic trigeminal neuralgia with syndrome of hyperactivity of liver-yang

A technology for trigeminal neuralgia and hyperactivity of liver yang, applied in the field of traditional Chinese medicine, can solve the problems of leukopenia, easy recurrence, and unacceptable for patients.

Inactive Publication Date: 2016-09-21
QINGDAO CHENDA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to cure clinically, and its recurrence rate is high, and there is no specific treatment method at present
Western medicine carbamazepine has serious side effects, some patients may experience leukopenia, etc., and they are prone to relapse after drug withdrawal; surgery, closure, radiofrequency temperature-controlled thermocoagulation and other treatments have certain effects, but they will cause numbness in the innervated area, and some Patients are difficult to accept

Method used

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  • Pharmaceutical composition for treating idiopathic trigeminal neuralgia with syndrome of hyperactivity of liver-yang
  • Pharmaceutical composition for treating idiopathic trigeminal neuralgia with syndrome of hyperactivity of liver-yang
  • Pharmaceutical composition for treating idiopathic trigeminal neuralgia with syndrome of hyperactivity of liver-yang

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Capsule prescription: 12 servings of donkey-hide gelatin, 18 servings of Ligustrum lucidum, 8 servings of dodder, 15 servings of wolfberry leaves, 10 servings of Gastrodia elata, 8 servings of Silengtong, 10 servings of Tianxian vine, 15 servings of small red ginseng, 25 servings of milk chai, 8 parts of Suanzaoren and 5 parts of Shicaiming.

[0054] Capsule preparation method: (1) according to the prescription, take Ligustrum lucidum seed, Cuscuta seed, Fructus Lycii, Gastrodia elata, Silentong, Tianxian rattan, red ginseng, milk chai, jujube seed and grind them into coarse powder, add 7 times the weight of Soak in water for 3-4 hours, decoct for 1-2 hours, filter and collect the filtrate, add water to the filter residue 5 times the weight of the medicinal material and decoct for 1-1.5 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.10 (measured at 60°C), add ethanol to make the alcohol content reach ...

Embodiment 2

[0060] Capsule prescription: 15 parts of donkey-hide gelatin, 15 parts of Ligustrum lucidum, 6 parts of dodder, 12 parts of wolfberry leaves, 12 parts of Gastrodia elata, 10 parts of Silentong, 10 parts of Tianxian vine, 18 parts of small red ginseng, 20 parts of milk chai, 10 parts of Suanzaoren and 5 parts of Shicaiming.

[0061] Capsule preparation method: (1) according to the prescription, take Ligustrum lucidum, Cuscuta, Fructus Lycii, Gastrodia elata, Silentong, Tianxianteng, small red ginseng, milk chai, jujube kernels and grind them into coarse powder, add 6 times the weight of Soak in water for 3-4 hours, decoct for 1-2 hours, filter to collect the filtrate, add water to the filter residue 3-6 times the weight of the medicinal material, decoct for 1-1.5 hours, combine the decoction, filter, and concentrate the filtrate to relative density under reduced pressure 1.08 (measured at 60°C), add ethanol to make the alcohol content reach 47%, let it stand for 12 hours, filte...

Embodiment 3

[0067] Capsule prescription: 10 parts of donkey-hide gelatin, 15 parts of Ligustrum lucidum, 6 parts of dodder, 10 parts of wolfberry leaves, 12 parts of Gastrodia elata, 7 parts of Silengtong, 8 parts of Tianxian vine, 15 parts of small red ginseng, 22 parts of milk chai, 10 parts of Suanzaoren and 6 parts of Shicaiming.

[0068] Capsule preparation method: carry out with reference to the operation of embodiment 1.

[0069] Ointment prescription: 10 parts of vine, 5 parts of Magnolia, 8 parts of Golden Retriever, and 6 parts of Butterfly Root.

[0070] Ointment preparation method: carry out with reference to the operation of embodiment 1.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses a pharmaceutical composition for treating idiopathic trigeminal neuralgia with syndrome of hyperactivity of liver-yang and a preparation method of the pharmaceutical composition. The pharmaceutical composition consists of a medicine for oral administration and a medicine for external application, wherein the medicine for oral administration is prepared from the following medicinal raw materials: colla corii asini, glossy privet fruit, seed of Chinese dodder, folium ilicis cornutae, rhizoma gastrodiae, ramulus uncariae cum uncis, herba aristolochiae, root of Yunnan madder, ficus lyrata, semen ziziphi spinosae and concha haliotidis; and the medicine for external application is prepared from the following medicinal raw materials: creeping mallotus roots and leaves, magnclia grandiflora lima, manyflower astilbe rhizome and runcinate knotweed root. According to the pharmaceutical composition disclosed by the invention, the medicine for oral administration focuses on nourishing yin and suppressing yang, calming wind and dredging collaterals; the medicine for external application focuses on eliminating exogenous wind, activating meridians to stop pain; through skin permeation and absorption, meridians and acupuncture points are stimulated; and by virtue of the means of combining external application and oral administration and integrating overall application and local application, the pharmaceutical composition can hit pathogenesis, so that purposes of rapidly relieving symptoms and removing diseases are achieved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating primary trigeminal neuralgia of hyperactivity of liver-yang type and a preparation method thereof. Background technique [0002] Primary trigeminal neuralgia refers to the pain that occurs in the distribution area of ​​the trigeminal nerve on one side or both sides of the face, such as electric discharge, knife-like pain symptoms, and an unbearable neurological disease for ordinary people. Talking, brushing teeth or breeze blowing on the face will cause labor pains. The severe pain in paroxysms lasts for several seconds or minutes. Its incidence rate is high, and the age is mostly after 40 years old, and the female is more than the male. Patients with trigeminal neuralgia often dare not wipe their faces, eat, or even swallow saliva, which affects their normal life and work. [0003] Modern medicine believes that the p...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K36/704A61P25/02A61K35/36A61K35/618
CPCA61K35/36A61K9/06A61K9/4841A61K35/618A61K36/185A61K36/264A61K36/39A61K36/43A61K36/47A61K36/575A61K36/60A61K36/638A61K36/704A61K36/725A61K36/74A61K36/8988A61K47/44A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 陈令浩
Owner QINGDAO CHENDA BIOLOGICAL SCI & TECH
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