Traditional Chinese herbal compound external preparation for treating hormone dependent dermatitis and preparation method and application thereof

A technology for dependent dermatitis and external preparations, applied in the field of traditional Chinese medicine compound external preparations and preparations, can solve the problems of affecting the function of the gastrointestinal tract and other organs, being difficult to achieve a therapeutic concentration, and having a low penetration rate of active ingredients, and achieving good The effect of skin tissue permeability, clear compatibility, and no adverse reactions

Active Publication Date: 2018-08-17
王文萱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] To sum up, the current traditional Chinese medicine compound prescriptions for the clinical treatment of hormone-dependent dermatitis, whether taken orally or externally, are mostly cold and cool medicines that nourish yin and cool serum, heat and detoxify, but long-term use can easily affect the gastrointestinal tract and other organs. function of organs, and even lead to irreversible drug-induced organ damage; the existing preparation technologies and processes of traditional Chinese medicine compound external preparations, such as water, tincture, paste, etc. agent or ointment, the content of effective ingredients in the preparation is low, the skin is irritating, the penetration rate of active ingredients is low, and it is difficult to achieve an effective therapeutic concentration

Method used

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  • Traditional Chinese herbal compound external preparation for treating hormone dependent dermatitis and preparation method and application thereof
  • Traditional Chinese herbal compound external preparation for treating hormone dependent dermatitis and preparation method and application thereof
  • Traditional Chinese herbal compound external preparation for treating hormone dependent dermatitis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: Preparation of the effective part of the compound Chinese medicine

[0044] (1) Take Polygonatum 60g, Poria cocos 30g, Radix Glycyrrhizae 20g and break into 40 mesh powders, add 10 times the amount of 85% ethanol to reflux and extract 3 to 5 times, each time for 2 hours, separate the extract, recover ethanol under low temperature and decompression, and decolorize the activated carbon. The separated liquid is filtered and separated on an ion exchange column, and the separated liquid received is concentrated to a specific gravity of 1.2. Obtain effective part A, spare.

[0045] (2) Take 30g of honeysuckle and 30g of chrysanthemum, add 10 times the amount of 85% ethanol, reflux extraction 3 to 5 times, each time for 1 hour, separate the extract, recover ethanol under low temperature and decompression, decolorize with activated carbon, filter and separate the liquid on an ion exchange column Separation is carried out, and the separation liquid received is con...

Embodiment 2

[0047] Embodiment 2: Preparation of the effective part of the compound Chinese medicine

[0048] (1) Take Polygonatum 60g, Poria cocos 35g, and licorice 30g, add 12 times the amount of water, decoct 3 times, 2 hours each time, separate the decoction, concentrate to a specific gravity of 1.12, stir quickly, add medical ethanol until the ethanol concentration is 85 %, the mixed liquid was allowed to stand for 4 hours, and after filtering and separating the supernatant to recover ethanol, add the same amount of activated carbon as medicinal materials and stir for 2 hours, filter to remove the activated carbon, separate the liquid on an ion exchange column, and concentrate the separated liquid to a specific gravity of 1.2. Obtain effective part A.

[0049] (2) Take 35g of honeysuckle and 35g of chrysanthemum, add 10 times the amount of water, decoct 3 times, 1 hour each time, separate the decoction, concentrate to a specific gravity of 1.12, stir rapidly, add medical ethanol until...

Embodiment 3

[0051] Embodiment 3: Preparation of effective part extract

[0052] Take sealwort 60g, poria cocos 35g, honeysuckle 35g, chrysanthemum 35g, licorice 15g, sealwort, poria cocos and licorice are crushed into 40 meshes and mixed with other medicinal materials, add 15 times the amount of 85% ethanol, soak for 12 hours, and slowly release the extract. The same method was used to extract 4 times, the extracts were combined, the ethanol was recovered by low-temperature and reduced-pressure distillation, decolorized by activated carbon, separated on an exchange column, and the separated solution was concentrated to a specific gravity of 1.2 to obtain the active ingredient extract of the traditional Chinese medicine compound.

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Abstract

The invention provides a traditional Chinese herbal compound external preparation for treating hormone dependent dermatitis. An effective part is prepared by the following Chinese herbal medicines according to the parts by weight: 5-80 parts of rhizoma polygonati, 5-60 parts of flos lonicerae, 5-60 parts of flos chrysanthemi, 5-60 parts of poria cocos and 3-60 parts of liquorice. The invention further discloses a preparation method and an application of the preparation. The preparation is capable of mainly using the rhizoma polygonati as a monarch drug, using the flos lonicerae and the flos chrysanthemi as ministerial drugs together, using the poria cocos as an adjuvant, and using the liquorice as a conductant drug for reconciling the drug properties of a whole prescription, using the effects of nourishing Yin and moistening dryness, removing pathogenic heat from blood and toxic material from body, clearing away heat and removing dampness, and dispelling wind and arresting itching as abasic treatment rule of the preparation, and promoting the repair of the hormone dependent dermatitis. The prescription is simple, accords with a traditional Chinese medicine theory of treating the hormone dependent dermatitis, and has the support and evidence of modern pharmacology achievements of each single Chinese herb. An extracting process for the compound effective part is simple, the effective ingredient content is high, the introduction of non-effective ingredients is reduced, a preparation technology is scientific, a transmittance rate of the effective ingredients in a pathologicaltissue is high, the animal experiment and human body trial effect is remarkable without the adverse reaction, the use is convenient and the adaptability is good.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for external use, its preparation method and application, in particular to a traditional Chinese medicine compound preparation for treating hormone-dependent dermatitis, its preparation method and its application. Background technique [0002] Steroid-dependent dermatitis is corticosteroid-dependent dermatitis, also known as glucocorticoid addiction dermatitis or topical glucocorticoid withdrawal dermatitis, is an inflammatory skin disease caused by inappropriate topical topical glucocorticoids, and the clinical manifestations are localized Gradually atrophy and thinning of the epidermis, telangiectasia, telangiectasia, thin skin, flushing, edema, erythema, desquamation, papules, acne-like and rosacea-like rashes, etc., with local tingling and burning Pain, itching, dryness, tightness, etc., and the skin lesions were relieved or disappeared when the steroids were used again, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P17/00
CPCA61K9/0014A61K36/076A61K36/287A61K36/355A61K36/484A61K36/8969A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P17/00A61K2300/00
Inventor 王文萱
Owner 王文萱
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