The invention provides a traditional Chinese herbal compound external preparation for treating hormone dependent dermatitis. An effective part is prepared by the following Chinese herbal medicines according to the parts by weight: 5-80 parts of rhizoma polygonati, 5-60 parts of flos lonicerae, 5-60 parts of flos chrysanthemi, 5-60 parts of poria cocos and 3-60 parts of liquorice. The invention further discloses a preparation method and an application of the preparation. The preparation is capable of mainly using the rhizoma polygonati as a monarch drug, using the flos lonicerae and the flos chrysanthemi as ministerial drugs together, using the poria cocos as an adjuvant, and using the liquorice as a conductant drug for reconciling the drug properties of a whole prescription, using the effects of nourishing Yin and moistening dryness, removing pathogenic heat from blood and toxic material from body, clearing away heat and removing dampness, and dispelling wind and arresting itching as abasic treatment rule of the preparation, and promoting the repair of the hormone dependent dermatitis. The prescription is simple, accords with a traditional Chinese medicine theory of treating the hormone dependent dermatitis, and has the support and evidence of modern pharmacology achievements of each single Chinese herb. An extracting process for the compound effective part is simple, the effective ingredient content is high, the introduction of non-effective ingredients is reduced, a preparation technology is scientific, a transmittance rate of the effective ingredients in a pathologicaltissue is high, the animal experiment and human body trial effect is remarkable without the adverse reaction, the use is convenient and the adaptability is good.