Traditional Chinese medicine compound external-application preparation for treating cicatrix and preparation method and application thereof

A technology for external preparations and compound recipes, which is applied in the field of traditional Chinese medicine compound external preparations and their preparation, can solve the problems of difficult infiltration of compound effect components, difficult to achieve therapeutic concentration, difficult to achieve clinical effects, etc., and achieve good economic benefits and social benefits. Benefit, significant efficacy and high product stability

Inactive Publication Date: 2015-11-18
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of research and treatment method puts aside the pathogenesis theory of scar and the compatibility theory of traditional Chinese medicine. It is similar to the prevention and treatment of chemical drugs. However, it is difficult to achieve the ideal clinical effect with a single chemical drug, a single traditional Chinese medicine monomer or a single traditional Chinese medicine. There are also unavoidable adverse reactions
2. Based on the pathogenesis theory and drug compatibility theory of traditional Chinese medicine, there were records about scars as early as the Western Han Dynasty, such as "Fifty-two Disease Prescriptions", "Taiping Shenghui Prescriptions", "Puji Prescriptions", etc., although variou

Method used

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  • Traditional Chinese medicine compound external-application preparation for treating cicatrix and preparation method and application thereof
  • Traditional Chinese medicine compound external-application preparation for treating cicatrix and preparation method and application thereof
  • Traditional Chinese medicine compound external-application preparation for treating cicatrix and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of effective part extract

[0027] (1) Grind 50g of Chuanshanlong, 50g of saponins, 20g of Wulingzhi, and 20g of Chinese gallnut into 20-60 mesh powder, add 5 times the amount of 85% ethanol, soak for 2 hours, slowly separate the extract, and extract for 3 ~5 times, the extracts were combined, concentrated under reduced pressure at low temperature and ethanol was recovered to obtain the effective fraction A for future use.

[0028] (2) Take 20g of Rhizoma Chuanxiong and 20g of Angelica sinensis and grind them into 40-60 mesh powder, CO 2 Supercritical extraction to obtain the effective fraction B for later use.

[0029] (3) Combine the effective parts A and B to obtain the extract of the effective parts of the Chinese medicine compound.

Embodiment 2

[0030] Embodiment 2: Preparation of effective part extract

[0031] (1) Grind 60g of Chuanshanlong, 60g of saponins, 50g of wulingzhi, and 50g of gallnut into 20-60 mesh powder, add 5 times the amount of 85% ethanol, soak for 2 hours, slowly separate the extract, and extract for 3 ~5 times, the extracts were combined, concentrated under reduced pressure at low temperature and ethanol was recovered to obtain the effective fraction A for future use.

[0032] (2) Take 50g of Rhizoma Chuanxiong and 50g of Angelica sinensis and grind them into 40-60 mesh powder, CO 2 Supercritical extraction to obtain the effective fraction B for later use.

[0033] (3) Combine the effective parts A and B to obtain the extract of the effective parts of the Chinese medicine compound.

Embodiment 3

[0034] Embodiment 3: Preparation of effective part extract

[0035] (1) Grind 10g of pangolin, 10g of saponins, 10g of wulingzhi, and 10g of gallnut into 20-60 mesh powder, add 5 times the amount of 85% ethanol, soak for 2 hours, slowly separate the extract, and extract for 3 ~5 times, the extracts were combined, concentrated under reduced pressure at low temperature and ethanol was recovered to obtain the effective fraction A for future use.

[0036] (2) Take 10g of Rhizoma Chuanxiong and 10g of Angelica sinensis and crush them into 40-60 mesh powder, soak in 200mL of petroleum ether (60°C-90°C) for 3 hours, filter, extract the dregs three times in the same way, and combine the petroleum ether extract , Recover petroleum ether under reduced pressure below 40°C to obtain effective fraction B for future use.

[0037] (3) Combine the effective parts A and B to obtain the extract of the effective parts of the Chinese medicine compound.

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Abstract

The invention discloses a traditional Chinese medicine compound external-application preparation for treating cicatrix. The effective parts, which are obtained through traditional Chinese medicine compound extraction, of the traditional Chinese medicine compound external-application preparation comprise the following Chinese herbal medicine by weight: 5-70g of Japanese yam rhizome, 5-70g of Chinese honeylocust spine, 5-60g of trogopterus dung, 5-60g of szechwan lovage rhizome, 5-60g of Chinese angelica root and 5-60g of gall nut. The invention further discloses a preparation method and application of the preparation. The preparation is simple in prescription formulating and accords with traditional Chinese medicine theories; the preparation is simple in extraction process and high in effective ingredient content; and the introduction of noneffective ingredients is reduced, so that the preparation is scientific in process; and moreover, the transmittance of the effective ingredients in lesion tissue is high, the animal experiment and human body trial effects are remarkable, and no adverse reaction occurs.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for external use and its preparation method and application, in particular to a traditional Chinese medicine compound preparation for treating scars and its preparation method and application. Background technique [0002] Hypertrophic scars and keloids are common pathological scars in clinic, and they are also a thorny problem in modern medicine. There are many kinds of treatment methods and different methods, all of which have achieved good curative effects, but they all have certain limitations. [0003] Western medicine prevents and treats scars mainly for the formation mechanism of scars, using surgical therapy, physical therapy, drug therapy or a combination of the above methods. Among them, surgical resection is the most commonly used treatment for hypertrophic scars, but the overall recurrence rate of simple resection is greater than 50%. Although surgical resection me...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P17/02
Inventor 王庆伟王顺利肖映红刘雪英李军昌刘朝晖张衍国徐媛
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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