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Traditional Chinese medicine preparation for treating spleen insufficiency induced acute coronary syndrome with accumulation of phlegm and blood stasis

A technology for coronary syndrome and traditional Chinese medicine preparations, which is applied to medical preparations containing active ingredients, drug combinations, and medical formulas, etc., and can solve problems such as unsatisfactory curative effect and long cooking time

Inactive Publication Date: 2017-05-17
FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two clinical examples can improve clinical symptoms and ECG performance, but there are certain limitations. In Liu’s article, the TCM symptom score of the treatment group dropped from 23.5±4.2 to 4.8±1.5, indicating chest pain, chest tightness, back pain, and fatigue , heaviness of limbs, shortness of breath, profuse phlegm, pale tongue, slippery pulse and other related symptoms have been improved, but the curative effect on symptoms such as edema, cold extremities, shortness of breath, sweating, pale complexion is not ideal; and the drug dosage forms are all decoctions , some aromatic components and fat-soluble components may be lost during the decoction process, the decoction time is long, and there are many kinds of drugs

Method used

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  • Traditional Chinese medicine preparation for treating spleen insufficiency induced acute coronary syndrome with accumulation of phlegm and blood stasis
  • Traditional Chinese medicine preparation for treating spleen insufficiency induced acute coronary syndrome with accumulation of phlegm and blood stasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A traditional Chinese medicine granule used for treating acute coronary syndrome caused by spleen deficiency with phlegm, blood stasis and poison, its raw materials are formulated as follows by weight: 10g of astragalus, 6g of clear pinellia, 5g of kudzu root, 10g of peach kernel, and 5g of trichosanthes , gardenia 5g, forsythia 10g.

[0025] The preparation method of the above-mentioned traditional Chinese medicine granules is as follows: Add 10 times the amount of water to the above-mentioned 7 medicinal materials, steam distillation to extract the volatile oil for 4 hours, and collect the distilled aqueous solution and volatile oil in another device; add 8 times the amount of water to decoct the medicinal residues Twice, 2 hours each time, combine the decoction and the distilled aqueous solution, filter, and concentrate to a thick paste (50°C) with a relative density of 1.20-1.22; the ratio of thick paste to dextrin and sucrose is 1:3:1 Mix, add appropriate amount of...

Embodiment 2

[0027] A traditional Chinese medicine granule for treating acute coronary syndrome with phlegm, blood stasis and poison caused by spleen deficiency, its raw materials are formulated as follows by weight: Astragalus 15g, Qingpinellia 10g, Pueraria lobata 10g, peach kernel 15g, Trichosanthes 10g , gardenia 10g, forsythia 15g.

Embodiment 3

[0029] A traditional Chinese medicine granule for treating acute coronary syndrome with phlegm, blood stasis and poison caused by spleen deficiency. The raw materials are formulated as follows by weight: Astragalus 10g, Pinellia chinensis 8g, Pueraria lobata 5g, peach kernel 10g, Trichosanthes 8g , gardenia 8g, forsythia 15g.

[0030] 1. Clinical trials.

[0031]A multi-center prospective cohort and nested case-control clinical trial design were adopted; compared with 25 patients in the control group (conventional drug treatment), 30 patients with acute coronary syndrome were intervened with the preparation prepared in Example 1, namely the test group, Observe the clinical efficacy of the preparation prepared in Example 1 for patients with acute coronary syndrome. See Table 1 for the survey results of re-admission of patients in the two groups within half a year; see Table 2 for the comparison of angina symptoms before and after treatment between the test group and the contro...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine preparation for treating spleen insufficiency induced acute coronary syndrome with accumulation of phlegm and blood stasis, including non-ST segment elevated myocardial infarction and unstable angina pectoris. The traditional Chinese medicine preparation is prepared from the following medicinal raw materials in weight: 10-15g of astragalus root, 6-10g of rhizoma pinelliae preparata, 5-10g of snake gourd fruit, 10-15g of peach seeds, 5-10g of radix puerariae, 10-15g of fructus forsythiae and 5-10g of cape jasmine. The traditional Chinese medicine preparation is prepared from pure traditional Chinese medicines and can treat chest distress, chest pain, pain radiating to shoulders and arms, chest pain involving the back and back pain involving the chest accompanied with palpitation, short breath, mental fatigue, cyanotic lips, stickiness in mouth, physical fatigue and the like; and proven by clinical tests, the traditional Chinese medicine preparation has obvious effects of improving angina pectoris, eliminating phlegm, dispersing blood stasis and detoxifying.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine preparation for treating acute coronary syndrome caused by phlegm, blood stasis and poison caused by spleen deficiency, specifically including non-ST segment elevation myocardial infarction and unstable angina. Background technique [0002] Acute coronary syndrome is a clinical symptom characterized by the basic pathophysiological characteristics of coronary artery blood flow reduction or blood flow interruption due to the rupture of coronary atherosclerotic plaque and local thrombus formation. It belongs to the category of "heart pain" in traditional Chinese medicine. With the improvement of living standards, the change of diet structure, high fat and high sugar intake lead to spleen dysfunction, internal growth of phlegm, formation of blood stasis, accumulation in the body, generation of heat toxin, damage to the heart colla...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K9/16A61P9/10
CPCA61K9/1652A61K36/428A61K36/481A61K36/488A61K36/634A61K36/736A61K36/744A61K36/8888A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张哲杨关林刘悦孔德昭孟繁丽王洋高晓宇潘嘉祥唐晶陈莹刘彤孙丽丽
Owner FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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