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Modified gelatin capsule

A gelatin capsule and modification technology, which is applied in the field of biomedicine, can solve the problems that the quality is affected by water content, and the quality of the capsule shell cannot be stabilized, etc., and achieve the effect of easy preparation of capsules, easier hanging of glue, and less breakage

Active Publication Date: 2014-07-23
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The above-mentioned prior art has the problem that as a modified gelatin capsule, its quality is still greatly affected by the water content, resulting in the unsteady defect of the capsule shell quality. To solve this problem, the main means at present is to control the gelatin capsule The storage environment mainly slows down the denaturation of gelatin capsules by controlling the temperature and humidity and keeping them airtight, but it fails to solve the problem fundamentally

Method used

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  • Modified gelatin capsule

Examples

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Embodiment 1

[0028] Embodiment 1: Preparation of gelatin-glutamic acid cross-linked complex

[0029] a. Take 1kg of gelatin and add it to an appropriate amount of water, heat it at 60°C to dissolve it completely, filter it to obtain a 10% gelatin aqueous solution for use; take 10 kg of glutamic acid, add an appropriate amount of 1% hydrochloric acid aqueous solution, and heat at 40°C for 10 minutes to obtain a 30% solution for use ;

[0030] b. Take 100ml of the gelatin aqueous solution described in a, add 10ml of carbodiimide aqueous solution with a mass fraction of 5%, stir and react for 5 minutes and mix evenly, then add 100ml of the glutamic acid hydrochloric acid solution described in a in batches, each addition is 10ml , stirred for 10 minutes after adding, and added again. After adding all the glutamic acid hydrochloric acid solution, stir and react for 30 minutes, cast the obtained solution in a plastic container, the thickness of the liquid layer is 1-2 cm, put it in a vacuum dry...

Embodiment 2

[0042] Take 78 parts of the gelatin-glutamic acid cross-linked compound prepared in Example 1, 12 parts of glycerin, add an appropriate amount of water, and prepare hollow hard capsules by the glue-dipping method.

Embodiment 3

[0044] Take 85 parts of the gelatin-glutamic acid cross-linked compound prepared in Example 1, 6 parts of glycerin, add an appropriate amount of water, and prepare hollow hard capsules by dipping in glue.

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Abstract

The invention provides a modified gelatin capsule. Modified gelatin is a gelatin-glutamic acid crosslinked compound. The compound has stronger viscosity compared with gelatin, thus being capable of more easily preparing the capsule; the prepared capsule is longer in shelf life, excellent in toughness and difficult to break.

Description

technical field [0001] The invention discloses a modified gelatin capsule and relates to the field of biomedicine. Background technique [0002] The main composition of gelatin is a mixture of polypeptide molecules with the same amino acid composition and a wide molecular weight distribution. There are a large number of hydroxyl groups in the molecular structure of gelatin, and there are many carboxyl groups and amino groups in addition, which makes gelatin extremely hydrophilic. Because of its good biocompatibility and biodegradability, it is widely used to make capsule shells. [0003] Because gelatin is extremely hydrophilic, moisture has a great influence on the quality of gelatin capsules. Too low moisture content will cause the capsule shell to become brittle and easy to crack, and too high moisture content will cause the capsule shell to become sticky and soften; the moisture content of gelatin capsules is not only affected by the production process, but also sensit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42C08H1/00
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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