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Sugar-free hypericum japonicum granule and preparation method thereof

A Tianjihuang, sugar-free technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as restricting clinical application and uncomfortable use by patients, and reducing single The effect of dosage, good sweetness and high sweetness

Inactive Publication Date: 2014-08-06
BENGBU HUOHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation contains a large amount of sucrose, which is not suitable for patients with diabetes, hypertension, obesity, etc., which greatly restricts its clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation method: Take 1500g Tianjihuang, add 10 times the amount of water, heat and decoct twice, 1 hour each time, combine the decoction, filter, concentrate to the extract with a relative density of 1.25-1.30 (60°C), depending on cassia seed 300g, 200g Pueraria root, add 10 times the amount of water, heat and decoct twice, 1 hour each time, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add 3 times the amount of 95% ethanol, let it settle for 24 hours, filter, take The supernatant, recovered ethanol, concentrated to a relative density of 1.25-1.30 to obtain the extract, put the extract into the granulator, add 4g of acesulfame potassium, 450g of dextrin, stir and mix well, make granules, dry, and make 600g, ready to serve. 3g per bag.

Embodiment 2

[0028] Preparation method: Take 1500g Tianjihuang, add 10 times the amount of water, heat and decoct twice, 1 hour each time, combine the decoction, filter, concentrate to the extract with a relative density of 1.25-1.30 (60°C), depending on cassia seed 300g, 200g Pueraria root, add 10 times the amount of water, heat and decoct twice, 1 hour each time, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add 3 times the amount of 95% ethanol, let it settle for 24 hours, filter, take The supernatant was recovered from ethanol, concentrated to a relative density of 1.25 to 1.30 to obtain an extract, the extract was added to a granulator, 5g of aspartame and 850g of dextrin were added, stirred and evenly mixed to make granules, dried, and prepared into 1000g, that is. 5g per bag.

Embodiment 3

[0030] Preparation method: Take 1500g Tianjihuang, add 10 times the amount of water, heat and decoct twice, 1 hour each time, combine the decoction, filter, concentrate to the extract with a relative density of 1.25-1.30 (60°C), depending on cassia seed 300g, 200g Pueraria root, add 10 times the amount of water, heat and decoct twice, 1 hour each time, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add 3 times the amount of 95% ethanol, let it settle for 24 hours, filter, take The supernatant, recovered ethanol, concentrated to a relative density of 1.25-1.30 to obtain the extract, put the extract into the granulator, add 4g of acesulfame potassium, 420g of soluble starch, stir, mix well, make granules, dry, and make 600g, ready to serve. 3g per bag.

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PUM

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Abstract

The invention relates to a sugar-free hypericum japonicum granule and a preparation method thereof. The sugar-free hypericum japonicum granule is characterized by consisting of 10-25 percent of hypericum japonicum extract, semen cassiae, 5-10 percent of kudzuvine root extract and a proper amount of auxiliary materials and flavoring agent, and each bag of sugar-free hypericum japonicum granule which contains not less than 0.55mg of hypericum japonicum based on quercetin (C15H10O7) is prepared. The sugar-free hypericum japonicum granule does not contain crane sugar and does not cause obesity due to long-term administration; the granule contains a flavoring agent, the taste of the original prescription is preserved, and the granule is conveniently taken by a patient; the preparation process is clear in process, the quality is controllable, and industrial production can be formed; and the sugar-free hypericum japonicum granule is wide in application range and can be used by diabetic patients and other sugar-free patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine granule preparations, and in particular relates to a sugar-free Tianjihuang granule containing extracts of Tianjihuang, cassia seeds and kudzu root and a preparation method thereof. Background technique [0002] Tianjihuang granules implement the drug standard of the State Food and Drug Administration: YBZ05102009, and the drug approval number: Z20090302. 【Prescription】Take 2000g of Dirtgrass (Tianjihuang), chop it, add water to decoct twice, add 14 times the amount of water for the first time, add 10 times the amount of water for the second time, each time for 1 hour, combine the decoction, Filtrate, concentrate the filtrate to an extract with a relative density of 1.25-1.30 (60°C), add sucrose, granulate, dry at 50-70°C, and make 1000g to obtain. [Specifications] 5g per bag. Tianjihuang in the prescription has the effects of clearing heat and dampness, dispelling stasis an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/16A61K47/36A61K47/18A61K47/22A61K47/26A61P1/16A61P31/14A61P31/20
Inventor 陈冬姚莉陈晓明
Owner BENGBU HUOHE PHARMA
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