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Ractopamine molecularly imprinted SPR sensor chip and preparation method thereof

A ractopamine, sensor chip technology, applied in instruments, scientific instruments, analytical materials, etc., can solve the problems of insensitive and accurate chip analysis, and achieve the effect of increasing the binding area, enhancing the plasma effect, and high sensitivity

Active Publication Date: 2016-04-20
INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention aims to solve the technical problem of insensitive and accurate analysis at low concentration of the existing molecularly imprinted polymer membrane chip, and provides a ractopamine molecularly imprinted SPR sensor chip and its preparation method

Method used

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  • Ractopamine molecularly imprinted SPR sensor chip and preparation method thereof
  • Ractopamine molecularly imprinted SPR sensor chip and preparation method thereof

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Experimental program
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Embodiment 1

[0026] Embodiment 1: The preparation method of ractopamine molecularly imprinted SPR sensor chip is carried out according to the following steps:

[0027] 1. Coating: adopt the method of vacuum evaporation coating, first deposit 2nm of chromium on the glass sheet, and then deposit 50nm of gold with a purity of 99.9999%, to obtain a coated glass sheet;

[0028] 2, cleaning: the mass percent concentration is 30% H 2 o 2 With a mass percent concentration of 98% H 2 SO 4 The volume ratio is 1:3 and mixed evenly to obtain a lotion; then use the lotion to wash the coated glass sheet obtained in step 1, then wash it with deionized water for 3 times, and finally wash it with absolute ethanol for 3 times, and let it dry in the air. After drying, the chip substrate is obtained;

[0029] 3. Preparation of ractopamine molecularly imprinted polymer nanospheres: Weigh ractopamine, methacrylic acid, ethylene glycol dimethacrylate, and azobisisobutyronitrile into acetonitrile, heat up to ...

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Abstract

The invention relates to the field of SPR sensor chips, and particularly relates to a ractopamine molecularly imprinted SPR sensor chip as well as a preparation method thereof. A ractopamine molecularly imprinted polymer, graphene nanogold, and 1-octyl-3- methylimidazole hexafluorophosphate are taken as chip substrate modifiers for the ractopamine molecularly imprinted SPR sensor chip. The ractopamine molecularly imprinted SPR sensor chip provided by the invention has high-specificity adsorption capability to ractopamine, and has obvious response signal variation to low-concentration ractopamine in samples. The ractopamine molecularly imprinted SPR chip prepared by the invention is simple in steps, is short in analysis time, and has relatively high accuracy and flexibility when being used for analyzing the low-concentration ractopamine residue.

Description

technical field [0001] The invention relates to the field of SPR sensor chips, in particular to a ractopamine molecularly imprinted SPR sensor chip and a preparation method thereof. Background technique [0002] Ractopamine is a phenol-type β-receptor agonist that can cause sympathetic nerve excitement. It is used in clinical medicine to treat congestive heart failure and muscular dystrophy. It can increase muscle and reduce fat deposition; When 5-10 times the therapeutic dose is used for livestock feeding, it can significantly promote animal protein deposition and increase feed remuneration. Eating such animal products will cause harm to human health. Strict standards have been established to control its illegal abuse Among them, China prohibits the use of any β-agonist drugs as feed additives, and the United States allows the use of ractopamine, with a residue limit of 50ng / g in pork and 30ng / g in beef. [0003] Currently, the main method for the analysis of β-agonist dru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/552
Inventor 王静佘永新杜欣蔚姚婷李腾飞王淼张艳欣于海龙金芬邵华金茂俊王珊珊
Owner INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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