Pharmaceutical composition for treating hyperlipemia and preparation method of pharmaceutical composition
A technology for hyperlipidemia and composition, which is applied in the field of medicine, can solve the problems of inaccurate medicinal ingredients and many impurities, and achieve significant lipid-lowering effect and the effect of treating hyperlipidemia
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experiment example 1
[0017] Experimental example 1, macroporous resin purification process experiment of rhubarb total anthraquinone
[0018] In the purification of rhubarb total anthraquinones, macroporous resins are mostly used for enrichment in the prior art. The present invention uses the adsorption rate and desorption rate of total anthraquinones as indicators to screen the best resin technology for rhubarb total anthraquinones.
[0019] 1. Resin type screening
[0020] Table 1 Comparison of adsorption properties of different types of resins on total anthraquinones of rhubarb
[0021] Resin model
Adsorption rate(%)
Desorption rate (%)
S-8
68.04
64.37
D101
64.21
72.27
AB-8
65.96
75.15
X-5
56.47
78.58
DA-201
61.40
71.39
[0022] From the comprehensive comparison of the experimental results in Table 1, it can be seen that the adsorption rate and desorption rate of AB-8 resin are high, so AB-8 is ...
experiment example 2
[0029] Experimental example 2, inclusion process experiment of Huoxiang volatile oil
[0030] The present invention studies the inclusion process of the volatile oil of Huoxiang, takes the encapsulation rate of the volatile oil of Huoxiang as an index, and the inclusion compound yield as indicators, and conducts research on factors such as the amount of β-cyclodextrin, the amount of water added, the inclusion temperature, and the inclusion time. After investigation, the results show that the aqueous solution of 6% beta-cyclodextrin is selected by weight and volume percentage, the volume-to-weight ratio of Huoxiang volatile oil and beta-cyclodextrin is 1ml:6g, the inclusion time is 3 hours, and the inclusion temperature is 50°C When the method is used, the inclusion compound yield and the inclusion rate of the volatile oil of Huoxiang are above 90%, which can meet the demand. Finally, 14.92 g of volatile oil clathrates were obtained from 200 g of patchouli.
experiment example 3
[0031] Experimental example 3, the resin purification process experiment of the total flavonoids of Huoxiang
[0032] The present invention selects the optimal resin process of the total flavonoids of Huoxiang according to the adsorption rate and desorption rate of the total flavonoids as indicators.
[0033] 1. Resin type screening
[0034] Table 4 Comparison of the adsorption performance of different types of resins on the total flavonoids of Huoxiang
[0035] Resin model
Adsorption rate(%)
Desorption rate (%)
S-8
78.25
60.58
D101
73.06
68.14
ADS-8
60.06
74.37
X-5
70.23
66.48
DA-201
56.37
81.59
[0036] From the comprehensive comparison of the experimental results in Table 4, it can be seen that the adsorption rate and desorption rate of D101 resin are high, so D101 is selected as the resin for purifying the total flavonoids of Huoxiang.
[0037] 2. Investigation of each res...
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