Pharmaceutical composition for treating hyperlipemia and preparation method of pharmaceutical composition

A technology for hyperlipidemia and composition, which is applied in the field of medicine, can solve the problems of inaccurate medicinal ingredients and many impurities, and achieve significant lipid-lowering effect and the effect of treating hyperlipidemia

Active Publication Date: 2014-09-03
JINHE TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The process of the above Huangxiang preparation is simple, there are too many impurities, and the effective ingredients are not exact, and only the volatile oil of Huoxiang is extracted, and the flavonoids are not extracted. However, the study found that the flavonoids are also important functional ingredients.

Method used

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  • Pharmaceutical composition for treating hyperlipemia and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating hyperlipemia and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating hyperlipemia and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0017] Experimental example 1, macroporous resin purification process experiment of rhubarb total anthraquinone

[0018] In the purification of rhubarb total anthraquinones, macroporous resins are mostly used for enrichment in the prior art. The present invention uses the adsorption rate and desorption rate of total anthraquinones as indicators to screen the best resin technology for rhubarb total anthraquinones.

[0019] 1. Resin type screening

[0020] Table 1 Comparison of adsorption properties of different types of resins on total anthraquinones of rhubarb

[0021] Resin model

Adsorption rate(%)

Desorption rate (%)

S-8

68.04

64.37

D101

64.21

72.27

AB-8

65.96

75.15

X-5

56.47

78.58

DA-201

61.40

71.39

[0022] From the comprehensive comparison of the experimental results in Table 1, it can be seen that the adsorption rate and desorption rate of AB-8 resin are high, so AB-8 is ...

experiment example 2

[0029] Experimental example 2, inclusion process experiment of Huoxiang volatile oil

[0030] The present invention studies the inclusion process of the volatile oil of Huoxiang, takes the encapsulation rate of the volatile oil of Huoxiang as an index, and the inclusion compound yield as indicators, and conducts research on factors such as the amount of β-cyclodextrin, the amount of water added, the inclusion temperature, and the inclusion time. After investigation, the results show that the aqueous solution of 6% beta-cyclodextrin is selected by weight and volume percentage, the volume-to-weight ratio of Huoxiang volatile oil and beta-cyclodextrin is 1ml:6g, the inclusion time is 3 hours, and the inclusion temperature is 50°C When the method is used, the inclusion compound yield and the inclusion rate of the volatile oil of Huoxiang are above 90%, which can meet the demand. Finally, 14.92 g of volatile oil clathrates were obtained from 200 g of patchouli.

experiment example 3

[0031] Experimental example 3, the resin purification process experiment of the total flavonoids of Huoxiang

[0032] The present invention selects the optimal resin process of the total flavonoids of Huoxiang according to the adsorption rate and desorption rate of the total flavonoids as indicators.

[0033] 1. Resin type screening

[0034] Table 4 Comparison of the adsorption performance of different types of resins on the total flavonoids of Huoxiang

[0035] Resin model

Adsorption rate(%)

Desorption rate (%)

S-8

78.25

60.58

D101

73.06

68.14

ADS-8

60.06

74.37

X-5

70.23

66.48

DA-201

56.37

81.59

[0036] From the comprehensive comparison of the experimental results in Table 4, it can be seen that the adsorption rate and desorption rate of D101 resin are high, so D101 is selected as the resin for purifying the total flavonoids of Huoxiang.

[0037] 2. Investigation of each res...

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Abstract

The invention discloses a pharmaceutical composition for treating hyperlipemia and a preparation method of the pharmaceutical compositon. The pharmaceutical composition is prepared from total anthraquinones, a clathrate compound of volatile oil of pogostemon cablin and total flavonoids of pogostemon cablin which are extracted from medicinal materials rheum officinale and pogostemon cablin. By using extracts as a formula base and adjusting and screening proportional optimization of three components which reduces blood lipid by taking pharmacology as indexes, compared with extracts naturally obtained by the original formula Huangxiang particles, the proportion of the clathrate compound of volatile oil of pogostemon cablin and the total flavonoids of pogostemon cablin is reduced by 50%. Results of animal pharmacological experiments verify that the pharmaceutical composition has a remarkable effect on reduction of blood lipid.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hyperlipidemia, which belongs to the technical field of medicine. Background technique [0002] Hyperlipidemia refers to a disease of increased blood lipid levels caused by various reasons, which can cause serious cardiovascular and cerebrovascular diseases. According to its clinical manifestations, it can be classified into the category of phlegm dampness and congestion in traditional Chinese medicine. Traditional medicine has the characteristics of syndrome differentiation and treatment and has the advantages of less toxic and side effects. The application of single Chinese medicine or Chinese medicine compound preparations in the treatment of hyperlipidemia has broad application prospects. [0003] Huangxiang granule is recorded in the national drug standard part, standard number: WS-10902 (ZD-0902)-2002, made of rhubarb and patchouli, has the effect of promoting blood circulation, r...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61P3/06
Inventor 李怀平姬涛魏永义杨文钰任松鹏
Owner JINHE TIBETAN MEDICINE
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