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A kind of water-soluble polysaccharide of gallwood and its preparation method and application

A water-soluble polysaccharide, bile wood technology, applied in allergic diseases, non-central analgesics, antipyretics, etc., to achieve the effect of high degree of purification

Active Publication Date: 2016-02-10
海南制药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there are no studies and reports on the extraction and efficacy of macromolecular substances in the bile wood, such as polysaccharides.

Method used

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  • A kind of water-soluble polysaccharide of gallwood and its preparation method and application
  • A kind of water-soluble polysaccharide of gallwood and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] (1) Preparation of the water-soluble polysaccharide of birchwood

[0064] (1) Extraction: take the stems of gallwood (containing bark, large branches and roots) and pulverize them to 10 mesh with a pulverizer at room temperature, get 5kg and put them into an extraction tank (pilot extraction and concentration unit), and then add 40L95% (w / w ) Medicinal alcohol, turn on the steam and reflux at 70-80°C for 2 hours; stop heating, and filter the ethanol solution through a 100-mesh stainless steel filter into the concentration tank, similar to the second and third times with 30L95% ( w / w) After reflux extraction with medicinal alcohol for 2 hours, the ethanol solution is sucked into a concentration tank. The medicinal materials that have been extracted by alcohol are taken out and dried at 45°C, in order to completely volatilize the alcohol in the medicinal materials. Then add it to the extraction tank, then add drinking water and boil for 3 times, add 40L water for the fir...

Embodiment 2

[0095] (1) Preparation of the water-soluble polysaccharide of birchwood

[0096] (1) Methanol treatment: Take 1 kg of the eucalyptus stem (including the skin) that is crushed into 20 meshes at room temperature and put it into an extraction tank, and use methanol with a concentration of 99% (w / w) to reflux extract 3 times in a water bath at 75°C: Add 8L of methanol for 2 hours once, and extract with 6L of methanol for the second and third times, 1 hour each time. After each extraction is completed, the methanol extract is filtered and poured out through a filter. After the third methanol treatment, the medicinal residues are placed in an environment of 50°C under reduced pressure. After the methanol is completely volatilized, add drinking water and boil for three times: the first time Add 7kg of water and boil for 2 hours; add 5kg of water for the last two times and boil for 1 hour; each time the water extract is filtered through a filter to the concentration tank. The combine...

Embodiment 3

[0106] (1) Preparation of the water-soluble polysaccharide of birchwood

[0107] (1) 70% methanol treatment: Take 200g of the 20-mesh gallwood stem (including the skin) and put it into the extraction tank at room temperature, and use the methanol with a concentration of 70% (w / w) to reflux extract 3 times in a water bath at 85°C : Add 1.6L of 70% (w / w) methanol for the first time to extract for 2h, and extract with 1.2L of 70% (w / w) methanol for the second and third times, each time for 1h. After each extraction is completed, the methanol extract is filtered through a filter and poured out. After the third methanol treatment, the medicinal residues are placed in an environment of 50°C under reduced pressure to volatilize the methanol completely, and then add purified water to extract 3 times: add 1.6 for the first time. kg of water, boil for 2 hours; add 1.2kg of water respectively for the last two times, and boil for 1 hour; each time the water extract is filtered through a f...

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Abstract

The invention discloses a water-soluble nauclea officinalis polysaccharide as well as a preparation method and application thereof. The preparation method comprises the following steps: treating nauclea officinalis chippings with alcohol or an alcoholic solution, and performing solid-liquid separation to obtain an alcohol extract and nauclea officinalis treated with the alcohol; removing the alcohol from the nauclea officinalis treated with the alcohol; adding water, extracting, and performing solid-liquid separation to obtain a water extract and residue; concentrating the water extract, performing solid-liquid separation, and selecting the solution; adding alcohol or alcoholic solution into the solution, performing solid-liquid separation, selecting sediment, and dissolving the sediment into water to obtain a water solution; dialyzing the water solution by using a dialysis bag of which the cut-off molecular weight is at least 5,000Da to obtain a water solution containing the water-soluble nauclea officinalis polysaccharide. The nauclea officinalis polysaccharide component is separated for the first time, and has pharmacological activity on anti-inflammation and immunity, so that the nauclea officinalis polysaccharide can be used for preparing immunity regulating medicaments or / and anti-inflammatory medicaments.

Description

technical field [0001] The invention relates to a macromolecular substance in gallwood and a preparation method thereof, in particular to a water-soluble polysaccharide of gallwood, a preparation method and application thereof. Background technique [0002] Gallwood is a Rubiaceae plant. The medicinal parts of Gallwood are stems, branches, bark and roots. The water extract of Gallwood has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. [0003] So far, it is generally believed that small molecular substances such as alkaloids and phenolic acids play a role in gallwood. The chemical composition of gallwood is recorded in the "Handbook of Commonly Used Chinese Herbal Medicine" by the Guangzhou Army as "the stem contains flavonoid glycosides and phenols"; Classes, in which alkaloids are: naucleficine, mauclefidine, nauclefline, 1-acetyl-carboline, 1-acetyl-carboline Nauclefiline and naucleidi-nal; alkaloid glycosides include nauclec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61P37/02A61P29/00
Inventor 蒲含林李秀峰赖潜
Owner 海南制药厂有限公司
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