Rat spinal-cord-injured neurogenic bladder model and preparation method thereof

A technology for spinal cord injury and rats, applied in the field of experimental model preparation, can solve the problem of high mortality and complication rate, and achieve the effects of reducing the molding rate and improving the survival rate.

Inactive Publication Date: 2014-10-08
HUNAN UNIV OF CHINESE MEDICINE
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Problems solved by technology

[0004] The present invention provides a neurogenic bladder model after spinal cord injury in rats and its preparation method, in order to obtain a set of more systematic models, and at the same time solve the problems of high mortality rate and high incidence of complications after modeling

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  • Rat spinal-cord-injured neurogenic bladder model and preparation method thereof
  • Rat spinal-cord-injured neurogenic bladder model and preparation method thereof
  • Rat spinal-cord-injured neurogenic bladder model and preparation method thereof

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Embodiment Construction

[0036] The embodiment of the present invention provides a neurogenic bladder model after spinal cord injury in rats and a preparation method thereof, so as to obtain a relatively systematic model and solve the problems of high mortality rate and complication rate after modeling.

[0037] In order to enable those skilled in the art to better understand the technical solutions in the embodiments of the present invention, and to make the above-mentioned purposes, features and advantages of the embodiments of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention are described below in conjunction with the accompanying drawings The program is described in further detail.

[0038] Please refer to the attached figure 1 , the embodiment of the present invention provides a preparation method of neurogenic bladder model after spinal cord injury in rats. Described preparation method comprises the following steps:

[0...

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Abstract

The invention belongs to the technical field of experimental model preparation, and discloses a rat spinal-cord-injured neurogenic bladder model and a preparation method of the rat spinal-cord-injured neurogenic bladder model. The preparation method comprises the steps that first, spinal cord transection is carried out on T10/11 intervertebral spaces of a first group of rats and the L2/3 intervertebral spaces of a second group of rats through a spinal cord transection method to form a segment-above-sacrum injury group and a sacral cord segment injury group respectively; second, operation nursing is carried out on the segment-above-sacrum injury group and the sacral cord segment injury group respectively; third, the spinal-cord-injured neurogenic bladder model is formed by selecting rats from the first group of rats and rats from the second group of rats according to preset conditions. According to the preparation method, the systematic spinal-cord-injured neurogenic bladder model is obtained, and the problems that the death rate of model rats after modeling is high and the occurrence rate of complications is high are solved.

Description

technical field [0001] The invention relates to the technical field of experimental model preparation, in particular to a neurogenic bladder model after spinal cord injury in rats and a preparation method thereof. Background technique [0002] At present, none of the literatures about the neurogenic bladder model after spinal cord injury in rats clearly indicates the injury location for making the neurogenic bladder model after spinal cord injury. The modified Allen's method (Zhang Huiping, et al., Clinical Surgical Impurities, 2007(15): 196-197), which is more commonly used now, simulates the fall of heavy objects and contusions to make spinal cord injury models, which has certain clinical similarities. However, since there are many factors affecting the degree of spinal cord injury (including complete injury and incomplete injury) in rats, the stability of the aforementioned spinal cord injury model is somewhat lacking. [0003] Hassan Shaker etc. (Hassan Shaker, etc.Neur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
Inventor 张泓田浩梅张雨辰艾坤陈楚淘匡静之谭洁李景兴
Owner HUNAN UNIV OF CHINESE MEDICINE
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